======= EREG =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: EREG
  * **<color #00a2e8>Official Name</color>**: epiregulin
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2069|2069]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O14944|O14944]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=EREG&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20EREG|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602061|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Ligand of the EGF receptor/EGFR and ERBB4. Stimulates EGFR and ERBB4 tyrosine phosphorylation (PubMed:9419975). Contributes to inflammation, wound healing, tissue repair, and oocyte maturation by regulating angiogenesis and vascular remodeling and by stimulating cell proliferation (PubMed:24631357). {ECO:0000269|PubMed:9419975, ECO:0000303|PubMed:24631357}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|primary follicle stage|
|luteinizing hormone signaling pathway|
|ovarian cumulus expansion|
|fused antrum stage|
|mammalian oogenesis stage|
|antral ovarian follicle growth|
|positive regulation of epidermal growth factor-activated receptor activity|
|keratinocyte proliferation|
|positive regulation of interleukin-6 biosynthetic process|
|negative regulation of smooth muscle cell differentiation|
|ovulation|
|oocyte maturation|
|regulation of interleukin-6 biosynthetic process|
|mRNA transcription|
|regulation of epidermal growth factor-activated receptor activity|
|positive regulation of epidermal growth factor receptor signaling pathway|
|female meiotic nuclear division|
|regulation of smooth muscle cell differentiation|
|ERBB2 signaling pathway|
|positive regulation of ERBB signaling pathway|
|epidermal growth factor receptor binding|
|positive regulation of signaling receptor activity|
|positive regulation of DNA replication|
|oocyte development|
|ovulation cycle process|
|oocyte differentiation|
|negative regulation of epidermal growth factor receptor signaling pathway|
|positive regulation of fibroblast proliferation|
|epidermal growth factor receptor signaling pathway|
|ovarian follicle development|
|negative regulation of ERBB signaling pathway|
|positive regulation of mitotic nuclear division|
|clathrin-coated vesicle membrane|
|negative regulation of muscle cell differentiation|
|positive regulation of protein tyrosine kinase activity|
|positive regulation of nuclear division|
|positive regulation of cytokine biosynthetic process|
|ovulation cycle|
|ERBB signaling pathway|
|oogenesis|
|regulation of fibroblast proliferation|
|regulation of epidermal growth factor receptor signaling pathway|
|positive regulation of smooth muscle cell proliferation|
|positive regulation of cell division|
|epithelial cell proliferation|
|female gonad development|
|regulation of protein tyrosine kinase activity|
|regulation of ERBB signaling pathway|
|development of primary female sexual characteristics|
|positive regulation of interleukin-6 production|
|regulation of cytokine biosynthetic process|
|female sex differentiation|
|regulation of DNA replication|
|negative regulation of epithelial cell proliferation|
|female gamete generation|
|regulation of smooth muscle cell proliferation|
|anatomical structure maturation|
|regulation of interleukin-6 production|
|positive regulation of mitotic cell cycle|
|meiotic nuclear division|
|regulation of muscle cell differentiation|
|cell maturation|
|growth factor activity|
|meiotic cell cycle process|
|positive regulation of protein kinase B signaling|
|regulation of cell division|
|regulation of mitotic nuclear division|
|regulation of signaling receptor activity|
|positive regulation of peptidyl-tyrosine phosphorylation|
|regulation of nuclear division|
|gonad development|
|development of primary sexual characteristics|
|regulation of protein kinase B signaling|
|meiotic cell cycle|
|developmental maturation|
|regulation of peptidyl-tyrosine phosphorylation|
|germ cell development|
|sex differentiation|
|keratinocyte differentiation|
|rhythmic process|
|nuclear division|
|positive regulation of cell cycle process|
|organelle fission|
|epidermal cell differentiation|
|angiogenesis|
|regulation of epithelial cell proliferation|
|positive regulation of innate immune response|
|cellular process involved in reproduction in multicellular organism|
|positive regulation of response to biotic stimulus|
|MAPK cascade|
|positive regulation of cell cycle|
|skin development|
|developmental growth|
|response to peptide hormone|
|growth|
|signal transduction by protein phosphorylation|
|blood vessel morphogenesis|
|epidermis development|
|reproductive structure development|
|reproductive system development|
|positive regulation of cytokine production|
|regulation of innate immune response|
|response to peptide|
|positive regulation of defense response|
|wound healing|
|blood vessel development|
|positive regulation of multi-organism process|
|vasculature development|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|cardiovascular system development|
|regulation of response to biotic stimulus|
|positive regulation of protein kinase activity|
|cell population proliferation|
|response to wounding|
|positive regulation of kinase activity|
|positive regulation of response to external stimulus|
|positive regulation of organelle organization|
|regulation of mitotic cell cycle|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|RNA biosynthetic process|
|tube morphogenesis|
|positive regulation of transferase activity|
|developmental process involved in reproduction|
|cytokine-mediated signaling pathway|
|negative regulation of cell population proliferation|
|epithelial cell differentiation|
|gamete generation|
|mRNA metabolic process|
|regulation of cytokine production|
|negative regulation of cell differentiation|
|enzyme linked receptor protein signaling pathway|
|regulation of cell cycle process|
|regulation of defense response|
|regulation of multi-organism process|
|regulation of protein kinase activity|
|multicellular organismal reproductive process|
|sexual reproduction|
|multicellular organism reproduction|
|tube development|
|membrane organization|
|positive regulation of immune response|
|circulatory system development|
|regulation of kinase activity|
|anatomical structure formation involved in morphogenesis|
|response to hormone|
|regulation of cell motility|
|positive regulation of cell population proliferation|
|negative regulation of developmental process|
|animal organ morphogenesis|
|protein phosphorylation|
|regulation of transferase activity|
|regulation of locomotion|
|regulation of cellular component movement|
|multi-organism reproductive process|
|cell cycle process|
|response to organonitrogen compound|
|cellular response to cytokine stimulus|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|positive regulation of phosphorylation|
|response to nitrogen compound|
|regulation of response to external stimulus|
|nucleobase-containing compound biosynthetic process|
|response to cytokine|
|epithelium development|
|cell-cell signaling|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|regulation of immune response|
|positive regulation of immune system process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|regulation of cell cycle|
|negative regulation of transcription, DNA-templated|
|positive regulation of cellular component organization|
|positive regulation of protein modification process|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of signal transduction|
|phosphorylation|
|regulation of organelle organization|
|organic cyclic compound biosynthetic process|
|G protein-coupled receptor signaling pathway|
|negative regulation of RNA metabolic process|
|cell cycle|
|negative regulation of cell communication|
|negative regulation of signaling|
|negative regulation of cellular macromolecule biosynthetic process|
|integral component of plasma membrane|
|reproductive process|
|reproduction|
|positive regulation of catalytic activity|
|negative regulation of nucleobase-containing compound metabolic process|
|regulation of protein phosphorylation|
|negative regulation of macromolecule biosynthetic process|
|response to endogenous stimulus|
|regulation of response to stress|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
|response to oxygen-containing compound|
|regulation of phosphorylation|
|extracellular space|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|cellular nitrogen compound biosynthetic process|
|cell development|
|positive regulation of signal transduction|
|regulation of immune system process|
|RNA metabolic process|
|intracellular signal transduction|
|positive regulation of protein metabolic process|
|cellular macromolecule biosynthetic process|
|negative regulation of gene expression|
|positive regulation of multicellular organismal process|
|tissue development|
|macromolecule biosynthetic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|positive regulation of macromolecule biosynthetic process|
|extracellular region|
|positive regulation of cellular biosynthetic process|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5248
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.08 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='EREG Expression in NALM6 Cells: 3.08'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>