======= ESRRB =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ESRRB
  * **<color #00a2e8>Official Name</color>**: estrogen related receptor beta
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2103|2103]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O95718|O95718]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ESRRB&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ESRRB|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602167|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a protein with similarity to the estrogen receptor. Its function is unknown; however, a similar protein in mouse plays an essential role in placental development. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Isoform 3: Transcription factor that binds a canonical ESRRB recognition (ERRE) sequence 5'TCAAGGTCA-3' localized on promoter and enhancer of targets genes regulating their expression or their transcription activity (PubMed:17920186, PubMed:19755138). Plays a role, in a LIF-independent manner, in maintainance of self-renewal and pluripotency of embryonic and trophoblast stem cells through different signaling pathways including FGF signaling pathway and Wnt signaling pathways. Upon FGF signaling pathway activation, interacts with KDM1A by directly binding to enhancer site of ELF5 and EOMES and activating their transcription leading to self-renewal of trophoblast stem cells. Also regulates expression of multiple rod-specific genes and is required for survival of this cell type (By similarity). Plays a role as transcription factor activator of GATA6, NR0B1, POU5F1 and PERM1 (PubMed:23836911). Plays a role as transcription factor repressor of NFE2L2 transcriptional activity and ESR1 transcriptional activity (PubMed:17920186, PubMed:19755138). During mitosis remains bound to a subset of interphase target genes, including pluripotency regulators, through the canonical ESRRB recognition (ERRE) sequence, leading to their transcriptional activation in early G1 phase. Can coassemble on structured DNA elements with other transcription factors like SOX2, POU5F1, KDM1A and NCOA3 to trigger ESRRB-dependent gene activation. This mechanism, in the case of SOX2 corecruitment prevents the embryonic stem cells (ESCs) to epiblast stem cells (EpiSC) transition through positive regulation of NR0B1 that inhibits the EpiSC transcriptional program. Also plays a role inner ear development by controlling expression of ion channels and transporters and in early placentation (By similarity). {ECO:0000250|UniProtKB:Q61539, ECO:0000269|PubMed:17920186, ECO:0000269|PubMed:19755138, ECO:0000269|PubMed:23836911}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|zf-C4|
|Hormone recep|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of transcription involved in G2/M transition of mitotic cell cycle|
|regulation of transcription involved in G2/M transition of mitotic cell cycle|
|positive regulation of transcription involved in G1/S transition of mitotic cell cycle|
|cell dedifferentiation|
|dedifferentiation|
|positive regulation of stem cell population maintenance|
|regulation of stem cell division|
|positive regulation of glycogen biosynthetic process|
|positive regulation of glycogen metabolic process|
|negative regulation of stem cell differentiation|
|positive regulation of glycolytic process|
|enhancer sequence-specific DNA binding|
|condensed chromosome|
|regulation of transcription involved in G1/S transition of mitotic cell cycle|
|integrator complex|
|regulation of stem cell population maintenance|
|regulation of glucan biosynthetic process|
|regulation of glycogen biosynthetic process|
|steroid binding|
|RNA polymerase II complex binding|
|stem cell division|
|regulation of glycogen metabolic process|
|regulation of polysaccharide biosynthetic process|
|positive regulation of glucose metabolic process|
|photoreceptor cell maintenance|
|regulation of polysaccharide metabolic process|
|positive regulation of purine nucleotide metabolic process|
|positive regulation of nucleotide metabolic process|
|positive regulation of ATP metabolic process|
|nuclear receptor activity|
|steroid hormone receptor activity|
|positive regulation of cellular carbohydrate metabolic process|
|retina homeostasis|
|positive regulation of carbohydrate metabolic process|
|regulation of glycolytic process|
|embryonic placenta development|
|regulation of carbohydrate catabolic process|
|regulation of carbohydrate biosynthetic process|
|RNA polymerase II distal enhancer sequence-specific DNA binding|
|regulation of glucose metabolic process|
|regulation of purine nucleotide metabolic process|
|regulation of stem cell differentiation|
|regulation of nucleotide metabolic process|
|G1/S transition of mitotic cell cycle|
|steroid hormone mediated signaling pathway|
|cell cycle G1/S phase transition|
|regulation of ATP metabolic process|
|G2/M transition of mitotic cell cycle|
|cell cycle G2/M phase transition|
|stem cell population maintenance|
|maintenance of cell number|
|positive regulation of small molecule metabolic process|
|regulation of cellular carbohydrate metabolic process|
|placenta development|
|regulation of generation of precursor metabolites and energy|
|intracellular receptor signaling pathway|
|regulation of cell division|
|hormone-mediated signaling pathway|
|transcription initiation from RNA polymerase II promoter|
|cellular response to steroid hormone stimulus|
|tissue homeostasis|
|inner ear development|
|regulation of carbohydrate metabolic process|
|DNA-templated transcription, initiation|
|ear development|
|mitotic cell cycle phase transition|
|cell cycle phase transition|
|multicellular organismal homeostasis|
|response to steroid hormone|
|transcription factor binding|
|anatomical structure homeostasis|
|positive regulation of cellular catabolic process|
|in utero embryonic development|
|sequence-specific DNA binding|
|reproductive structure development|
|regulation of small molecule metabolic process|
|reproductive system development|
|positive regulation of catabolic process|
|embryonic organ development|
|DNA-binding transcription activator activity, RNA polymerase II-specific|
|transcription by RNA polymerase II|
|cell division|
|RNA polymerase II proximal promoter sequence-specific DNA binding|
|cellular response to lipid|
|cellular response to organic cyclic compound|
|sensory organ development|
|mitotic cell cycle process|
|cellular response to hormone stimulus|
|chordate embryonic development|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|embryo development ending in birth or egg hatching|
|RNA biosynthetic process|
|developmental process involved in reproduction|
|DNA-binding transcription factor activity|
|mitotic cell cycle|
|negative regulation of cell differentiation|
|regulation of cellular catabolic process|
|zinc ion binding|
|response to lipid|
|response to hormone|
|response to organic cyclic compound|
|negative regulation of developmental process|
|embryo development|
|regulation of catabolic process|
|cell cycle process|
|positive regulation of phosphorylation|
|nucleobase-containing compound biosynthetic process|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|positive regulation of transcription by RNA polymerase II|
|cellular response to endogenous stimulus|
|organic cyclic compound biosynthetic process|
|cell cycle|
|positive regulation of developmental process|
|reproductive process|
|reproduction|
|response to endogenous stimulus|
|positive regulation of transcription, DNA-templated|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|regulation of phosphorylation|
|cellular nitrogen compound biosynthetic process|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|homeostatic process|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|macromolecule biosynthetic process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp10|CCCP 0.1μM R00 exp10]]|1.84|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4950
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -2.79 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ESRRB Expression in NALM6 Cells: -2.79'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>