======= ETS1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ETS1
  * **<color #00a2e8>Official Name</color>**: ETS proto-oncogene 1, transcription factor
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2113|2113]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P14921|P14921]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ETS1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ETS1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/164720|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the ETS family of transcription factors, which are defined by the presence of a conserved ETS DNA-binding domain that recognizes the core consensus DNA sequence GGAA/T in target genes. These proteins function either as transcriptional activators or repressors of numerous genes, and are involved in stem cell development, cell senescence and death, and tumorigenesis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jul 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Transcription factor. Directly controls the expression of cytokine and chemokine genes in a wide variety of different cellular contexts. May control the differentiation, survival and proliferation of lymphoid cells. May also regulate angiogenesis through regulation of expression of genes controlling endothelial cell migration and invasion. {ECO:0000269|PubMed:10698492, ECO:0000269|PubMed:11909962, ECO:0000269|PubMed:15247905, ECO:0000269|PubMed:15592518}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ets|
|SAM PNT|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|PML body organization|
|pri-miRNA transcription by RNA polymerase II|
|response to laminar fluid shear stress|
|positive regulation of leukocyte adhesion to vascular endothelial cell|
|angiogenesis involved in wound healing|
|regulation of extracellular matrix disassembly|
|nuclear body organization|
|estrous cycle|
|regulation of leukocyte adhesion to vascular endothelial cell|
|hypothalamus development|
|histone acetyltransferase binding|
|positive regulation of erythrocyte differentiation|
|response to fluid shear stress|
|regulation of extracellular matrix organization|
|pituitary gland development|
|regulation of erythrocyte differentiation|
|positive regulation of blood vessel endothelial cell migration|
|ovulation cycle|
|cellular response to hydrogen peroxide|
|diencephalon development|
|regulation of blood vessel endothelial cell migration|
|positive regulation of myeloid cell differentiation|
|positive regulation of endothelial cell migration|
|limbic system development|
|cellular response to antibiotic|
|response to hydrogen peroxide|
|endocrine system development|
|cellular response to reactive oxygen species|
|nucleus organization|
|response to estradiol|
|negative regulation of inflammatory response|
|positive regulation of inflammatory response|
|positive regulation of epithelial cell migration|
|regulation of endothelial cell migration|
|positive regulation of angiogenesis|
|female pregnancy|
|positive regulation of vasculature development|
|positive regulation of hemopoiesis|
|response to reactive oxygen species|
|response to interleukin-1|
|transcription factor complex|
|negative regulation of defense response|
|multi-multicellular organism process|
|response to mechanical stimulus|
|cellular response to toxic substance|
|positive regulation of leukocyte cell-cell adhesion|
|regulation of epithelial cell migration|
|regulation of myeloid cell differentiation|
|cellular response to oxidative stress|
|positive regulation of cell-cell adhesion|
|rhythmic process|
|regulation of angiogenesis|
|regulation of leukocyte cell-cell adhesion|
|response to antibiotic|
|angiogenesis|
|regulation of vasculature development|
|transcription factor binding|
|regulation of inflammatory response|
|response to hypoxia|
|response to decreased oxygen levels|
|negative regulation of response to external stimulus|
|response to oxygen levels|
|forebrain development|
|response to oxidative stress|
|regulation of cell-cell adhesion|
|cellular response to drug|
|positive regulation of cell adhesion|
|blood vessel morphogenesis|
|gland development|
|DNA-binding transcription activator activity, RNA polymerase II-specific|
|regulation of hemopoiesis|
|positive regulation of defense response|
|wound healing|
|transcription by RNA polymerase II|
|blood vessel development|
|positive regulation of cell migration|
|RNA polymerase II proximal promoter sequence-specific DNA binding|
|response to toxic substance|
|vasculature development|
|cardiovascular system development|
|positive regulation of cell motility|
|response to inorganic substance|
|positive regulation of cellular component movement|
|positive regulation of locomotion|
|response to wounding|
|positive regulation of response to external stimulus|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|RNA biosynthetic process|
|tube morphogenesis|
|DNA-binding transcription factor activity|
|negative regulation of cell population proliferation|
|regulation of cell adhesion|
|brain development|
|regulation of defense response|
|head development|
|multicellular organismal reproductive process|
|multicellular organism reproduction|
|tube development|
|regulation of cell migration|
|response to lipid|
|circulatory system development|
|anatomical structure formation involved in morphogenesis|
|response to hormone|
|regulation of cell motility|
|positive regulation of cell population proliferation|
|response to organic cyclic compound|
|positive regulation of cell differentiation|
|central nervous system development|
|regulation of locomotion|
|regulation of cellular component movement|
|multi-organism reproductive process|
|response to drug|
|cellular response to oxygen-containing compound|
|regulation of anatomical structure morphogenesis|
|identical protein binding|
|cell motility|
|localization of cell|
|regulation of response to external stimulus|
|nucleobase-containing compound biosynthetic process|
|response to cytokine|
|positive regulation of immune system process|
|response to abiotic stimulus|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|positive regulation of transcription by RNA polymerase II|
|organic cyclic compound biosynthetic process|
|locomotion|
|positive regulation of developmental process|
|reproductive process|
|reproduction|
|DNA binding|
|response to endogenous stimulus|
|regulation of response to stress|
|positive regulation of transcription, DNA-templated|
|movement of cell or subcellular component|
|response to oxygen-containing compound|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|cellular nitrogen compound biosynthetic process|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|regulation of immune system process|
|RNA metabolic process|
|cellular response to stress|
|cellular macromolecule biosynthetic process|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|macromolecule biosynthetic process|
|regulation of cell differentiation|
|immune response|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 14816
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.92 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ETS1 Expression in NALM6 Cells: 4.92'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>