======= EXOC4 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: EXOC4
  * **<color #00a2e8>Official Name</color>**: exocyst complex component 4
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=60412|60412]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96A65|Q96A65]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=EXOC4&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20EXOC4|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/608185|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a component of the exocyst complex, a multiple protein complex essential for targeting exocytic vesicles to specific docking sites on the plasma membrane. Though best characterized in yeast, the component proteins and functions of exocyst complex have been demonstrated to be highly conserved in higher eukaryotes. At least eight components of the exocyst complex, including this protein, are found to interact with the actin cytoskeletal remodeling and vesicle transport machinery. The complex is also essential for the biogenesis of epithelial cell surface polarity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Sec8 exocyst|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|vesicle tethering involved in exocytosis|
|myelin sheath abaxonal region|
|paraxial mesoderm formation|
|growth cone membrane|
|vesicle tethering|
|paraxial mesoderm morphogenesis|
|Ral GTPase binding|
|paraxial mesoderm development|
|exocyst|
|Flemming body|
|vesicle docking involved in exocytosis|
|mesenchyme morphogenesis|
|Golgi to plasma membrane transport|
|microvillus|
|vesicle docking|
|mesoderm formation|
|exocytic process|
|mesoderm morphogenesis|
|PDZ domain binding|
|vesicle targeting|
|vesicle-mediated transport to the plasma membrane|
|post-Golgi vesicle-mediated transport|
|protein N-terminus binding|
|formation of primary germ layer|
|mesoderm development|
|gastrulation|
|protein targeting to membrane|
|organelle localization by membrane tethering|
|regulation of macroautophagy|
|establishment of vesicle localization|
|membrane docking|
|vesicle localization|
|mesenchyme development|
|establishment of protein localization to membrane|
|synapse|
|regulation of autophagy|
|protein targeting|
|establishment of organelle localization|
|Golgi vesicle transport|
|anterograde trans-synaptic signaling|
|chemical synaptic transmission|
|trans-synaptic signaling|
|synaptic signaling|
|protein localization to membrane|
|tissue morphogenesis|
|embryonic morphogenesis|
|organelle localization|
|exocytosis|
|regulation of cellular catabolic process|
|anatomical structure formation involved in morphogenesis|
|animal organ morphogenesis|
|embryo development|
|regulation of catabolic process|
|intracellular protein transport|
|secretion by cell|
|export from cell|
|cell-cell signaling|
|secretion|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|tissue development|
|establishment of localization in cell|
|nitrogen compound transport|
|vesicle-mediated transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp145|PNU96415E 10μM R03 exp145]]|-2|
|[[:results:exp539|42°C R08 exp539]]|1.73|
|[[:results:exp443|SNS-032 15μM R08 exp443]]|2.23|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:t:thg1l|THG1L]]|0.659|
|[[:human genes:r:rpp21|RPP21]]|0.614|
|[[:human genes:u:uap1|UAP1]]|0.598|
|[[:human genes:d:dohh|DOHH]]|0.592|
|[[:human genes:r:rtcb|RTCB]]|0.589|
|[[:human genes:g:gnb1l|GNB1L]]|0.58|
|[[:human genes:r:rptor|RPTOR]]|0.578|
|[[:human genes:p:pmm2|PMM2]]|0.573|
|[[:human genes:a:alg1|ALG1]]|0.573|
|[[:human genes:r:rnmt|RNMT]]|0.57|
|[[:human genes:g:gmppb|GMPPB]]|0.568|
|[[:human genes:v:vezt|VEZT]]|0.555|
|[[:human genes:t:triap1|TRIAP1]]|0.555|
|[[:human genes:d:dpagt1|DPAGT1]]|0.554|
|[[:human genes:a:alg13|ALG13]]|0.548|
|[[:human genes:g:gfpt1|GFPT1]]|0.544|
|[[:human genes:a:atp5j|ATP5J]]|0.544|
|[[:human genes:a:alg2|ALG2]]|0.542|
|[[:human genes:l:lsm11|LSM11]]|0.528|
|[[:human genes:e:exoc3|EXOC3]]|0.526|
|[[:human genes:g:gtf3c2|GTF3C2]]|0.526|
|[[:human genes:h:hspd1|HSPD1]]|0.525|
|[[:human genes:r:rpe|RPE]]|0.523|
|[[:human genes:a:atxn10|ATXN10]]|0.522|
|[[:human genes:a:adsl|ADSL]]|0.52|
|[[:human genes:d:dhps|DHPS]]|0.518|
|[[:human genes:s:srp14|SRP14]]|0.517|
|[[:human genes:n:nae1|NAE1]]|0.516|
|[[:human genes:p:polr3h|POLR3H]]|0.513|
|[[:human genes:g:gtf3c4|GTF3C4]]|0.513|
|[[:human genes:r:rpn1|RPN1]]|0.512|
|[[:human genes:d:ddost|DDOST]]|0.507|
|[[:human genes:g:gtf3c3|GTF3C3]]|0.504|
|[[:human genes:t:tsen54|TSEN54]]|0.502|
|[[:human genes:g:gemin6|GEMIN6]]|0.501|
|[[:human genes:t:tamm41|TAMM41]]|0.498|
|[[:human genes:e:elp2|ELP2]]|0.497|
|[[:human genes:d:ddx20|DDX20]]|0.497|
|[[:human genes:g:gtf3c6|GTF3C6]]|0.496|
|[[:human genes:s:ssb|SSB]]|0.492|
|[[:human genes:a:alg14|ALG14]]|0.49|
|[[:human genes:e:eprs|EPRS]]|0.489|
|[[:human genes:y:yars|YARS]]|0.489|
|[[:human genes:p:ppcs|PPCS]]|0.489|
|[[:human genes:r:rabggtb|RABGGTB]]|0.488|
|[[:human genes:t:trnt1|TRNT1]]|0.487|
|[[:human genes:c:ccdc101|CCDC101]]|0.485|
|[[:human genes:o:osgep|OSGEP]]|0.484|
|[[:human genes:e:elp3|ELP3]]|0.484|
|[[:human genes:e:exoc5|EXOC5]]|0.483|
|[[:human genes:t:txnl4b|TXNL4B]]|0.483|
|[[:human genes:t:tti2|TTI2]]|0.482|
|[[:human genes:a:aars|AARS]]|0.48|
|[[:human genes:p:ppa2|PPA2]]|0.479|
|[[:human genes:o:oraov1|ORAOV1]]|0.478|
|[[:human genes:h:haus8|HAUS8]]|0.478|
|[[:human genes:m:med16|MED16]]|0.477|
|[[:human genes:p:pam16|PAM16]]|0.476|
|[[:human genes:c:cbfb|CBFB]]|0.474|
|[[:human genes:u:uhrf1|UHRF1]]|0.473|
|[[:human genes:a:atp5o|ATP5O]]|0.472|
|[[:human genes:v:vhl|VHL]]|0.47|
|[[:human genes:t:tprkb|TPRKB]]|0.47|
|[[:human genes:g:gemin8|GEMIN8]]|0.467|
|[[:human genes:u:ube2g2|UBE2G2]]|0.466|
|[[:human genes:c:csnk2b|CSNK2B]]|0.465|
|[[:human genes:d:dr1|DR1]]|0.464|
|[[:human genes:t:timm13|TIMM13]]|0.462|
|[[:human genes:p:ppp4c|PPP4C]]|0.462|
|[[:human genes:t:ten1|TEN1]]|0.462|
|[[:human genes:a:alg5|ALG5]]|0.461|
|[[:human genes:t:taz|TAZ]]|0.459|
|[[:human genes:r:romo1|ROMO1]]|0.458|
|[[:human genes:p:ppp6c|PPP6C]]|0.457|
|[[:human genes:u:urm1|URM1]]|0.456|
|[[:human genes:w:wdr24|WDR24]]|0.454|
|[[:human genes:c:casp9|CASP9]]|0.452|
|[[:human genes:m:mbtps2|MBTPS2]]|0.451|
|[[:human genes:t:telo2|TELO2]]|0.45|
|[[:human genes:z:zrsr2|ZRSR2]]|0.45|
|[[:human genes:b:bap1|BAP1]]|0.448|
|[[:human genes:t:thoc3|THOC3]]|0.446|
|[[:human genes:f:fh|FH]]|0.446|
|[[:human genes:t:trmt5|TRMT5]]|0.445|
|[[:human genes:p:pdap1|PDAP1]]|0.443|
|[[:human genes:s:snapc5|SNAPC5]]|0.443|
|[[:human genes:p:pelo|PELO]]|0.442|
|[[:human genes:s:slc25a26|SLC25A26]]|0.441|
|[[:human genes:t:ttc4|TTC4]]|0.439|
|[[:human genes:k:kdsr|KDSR]]|0.438|
|[[:human genes:s:sdha|SDHA]]|0.438|
|[[:human genes:t:tsen34|TSEN34]]|0.437|
|[[:human genes:c:cep57|CEP57]]|0.437|
|[[:human genes:o:otud5|OTUD5]]|0.437|
|[[:human genes:m:mtor|MTOR]]|0.435|
|[[:human genes:k:kdm8|KDM8]]|0.435|
|[[:human genes:z:zbtb11|ZBTB11]]|0.435|
|[[:human genes:t:tbcb|TBCB]]|0.434|
|[[:human genes:t:trim28|TRIM28]]|0.434|
|[[:human genes:c:crcp|CRCP]]|0.433|
|[[:human genes:t:taf1a|TAF1A]]|0.432|
|[[:human genes:a:abcb7|ABCB7]]|0.432|
|[[:human genes:g:gpn2|GPN2]]|0.431|
|[[:human genes:d:dad1|DAD1]]|0.43|
|[[:human genes:v:vrk1|VRK1]]|0.428|
|[[:human genes:t:trmt10a|TRMT10A]]|0.428|
|[[:human genes:f:faf2|FAF2]]|0.428|
|[[:human genes:p:plaa|PLAA]]|0.427|
|[[:human genes:t:tmem41b|TMEM41B]]|0.427|
|[[:human genes:t:tti1|TTI1]]|0.427|
|[[:human genes:b:bak1|BAK1]]|0.426|
|[[:human genes:d:dhrsx|DHRSX]]|0.426|
|[[:human genes:d:dolk|DOLK]]|0.425|
|[[:human genes:l:lamtor4|LAMTOR4]]|0.424|
|[[:human genes:a:apaf1|APAF1]]|0.423|
|[[:human genes:d:ddx55|DDX55]]|0.423|
|[[:human genes:n:nsmce1|NSMCE1]]|0.423|
|[[:human genes:h:hccs|HCCS]]|0.422|
|[[:human genes:b:bcs1l|BCS1L]]|0.422|
|[[:human genes:c:c21orf59|C21orf59]]|0.422|
|[[:human genes:a:atp5a1|ATP5A1]]|0.422|
|[[:human genes:e:eef1e1|EEF1E1]]|0.421|
|[[:human genes:n:nars|NARS]]|0.421|
|[[:human genes:s:sec62|SEC62]]|0.421|
|[[:human genes:s:srp68|SRP68]]|0.42|
|[[:human genes:c:cct7|CCT7]]|0.418|
|[[:human genes:d:dpf2|DPF2]]|0.417|
|[[:human genes:v:vps41|VPS41]]|0.416|
|[[:human genes:w:wdr1|WDR1]]|0.416|
|[[:human genes:g:gemin7|GEMIN7]]|0.416|
|[[:human genes:o:oip5|OIP5]]|0.415|
|[[:human genes:r:rft1|RFT1]]|0.415|
|[[:human genes:d:dicer1|DICER1]]|0.415|
|[[:human genes:m:med4|MED4]]|0.414|
|[[:human genes:w:wdr59|WDR59]]|0.413|
|[[:human genes:u:utp23|UTP23]]|0.412|
|[[:human genes:t:tbca|TBCA]]|0.411|
|[[:human genes:e:eno1|ENO1]]|0.41|
|[[:human genes:e:eif4e|EIF4E]]|0.41|
|[[:human genes:r:rnaseh2b|RNASEH2B]]|0.41|
|[[:human genes:n:naf1|NAF1]]|0.408|
|[[:human genes:e:elac2|ELAC2]]|0.407|
|[[:human genes:m:mllt1|MLLT1]]|0.407|
|[[:human genes:c:ctc1|CTC1]]|0.406|
|[[:human genes:l:lsm10|LSM10]]|0.406|
|[[:human genes:c:c14orf166|C14orf166]]|0.406|
|[[:human genes:p:polr3b|POLR3B]]|0.405|
|[[:human genes:a:atp5b|ATP5B]]|0.405|
|[[:human genes:u:uxt|UXT]]|0.405|
|[[:human genes:m:med23|MED23]]|0.404|
|[[:human genes:w:wdr92|WDR92]]|0.404|
|[[:human genes:m:metap2|METAP2]]|0.404|
|[[:human genes:d:dusp12|DUSP12]]|0.404|
|[[:human genes:g:gemin5|GEMIN5]]|0.403|
|[[:human genes:d:ddx1|DDX1]]|0.402|
|[[:human genes:c:crls1|CRLS1]]|0.401|
|[[:human genes:e:ercc2|ERCC2]]|0.4|
|[[:human genes:n:nsd1|NSD1]]|0.4|
|[[:human genes:a:alg6|ALG6]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 22/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|1/26|
|breast|0/33|
|central nervous system|2/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|1/13|
|fibroblast|0/1|
|gastric|1/16|
|kidney|0/21|
|liver|0/20|
|lung|3/75|
|lymphocyte|2/16|
|ovary|1/26|
|pancreas|0/24|
|peripheral nervous system|1/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|1/9|
|thyroid|0/2|
|upper aerodigestive|1/22|
|urinary tract|1/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2326
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.46 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='EXOC4 Expression in NALM6 Cells: 5.46'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>