======= EXOC8 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: EXOC8
  * **<color #00a2e8>Official Name</color>**: exocyst complex component 8
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=149371|149371]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8IYI6|Q8IYI6]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=EXOC8&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20EXOC8|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/615283|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a component of the exocyst complex, an evolutionarily conserved multi-protein complex that plays a critical role in vesicular trafficking and the secretory pathway by targeting post-Golgi vesicles to the plasma membrane. This protein is a target of activated Ral subfamily of GTPases and thereby regulates exocytosis by tethering vesicles to the plasma membrane. Mutations in this gene may be related to Joubert syndrome. [provided by RefSeq, Sep 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Vps51|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|Ral GTPase binding|
|exocyst|
|cell leading edge|
|Golgi to plasma membrane transport|
|extracellular matrix disassembly|
|endosome organization|
|vesicle-mediated transport to the plasma membrane|
|post-Golgi vesicle-mediated transport|
|late endosome|
|growth cone|
|regulation of macroautophagy|
|vesicle organization|
|regulation of autophagy|
|extracellular matrix organization|
|Golgi vesicle transport|
|extracellular structure organization|
|cellular component disassembly|
|endomembrane system organization|
|perinuclear region of cytoplasm|
|exocytosis|
|regulation of cellular catabolic process|
|regulation of catabolic process|
|secretion by cell|
|export from cell|
|secretion|
|protein transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|nitrogen compound transport|
|vesicle-mediated transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp273|Cisplatin 0.35μM R06 exp273]]|-2.12|
|[[:results:exp286|HMS-I2 1μM R06 exp286]]|-2.06|
|[[:results:exp298|Sucrose 20000μM R06 exp298]]|-2.04|
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|-2.01|
|[[:results:exp280|Daidzin 10μM R06 exp280]]|-1.88|
|[[:results:exp466|Cannabidiol 20μM R08 exp466]]|-1.82|
|[[:results:exp344|Chlorpromazine 10μM R07 exp344]]|1.75|
|[[:results:exp399|Salubrinal 20μM R07 exp399]]|1.77|
|[[:results:exp418|Tunicamycin 0.04μM R07 exp418]]|1.79|
|[[:results:exp102|Nifuroxazide 5μM R03 exp102]]|2.01|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 14/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|1/28|
|blood|0/28|
|bone|1/26|
|breast|0/33|
|central nervous system|1/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|1/21|
|liver|0/20|
|lung|2/75|
|lymphocyte|1/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|1/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2327
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.51 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='EXOC8 Expression in NALM6 Cells: 5.51'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>