======= EXOSC6 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: EXOSC6
  * **<color #00a2e8>Official Name</color>**: exosome component 6
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=118460|118460]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q5RKV6|Q5RKV6]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=EXOSC6&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20EXOSC6|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606490|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. {ECO:0000269|PubMed:21255825}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|RNase PH|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|polyadenylation-dependent snoRNA 3-end processing|
|U4 snRNA 3-end processing|
|nuclear-transcribed mRNA catabolic process, exonucleolytic, 3-5|
|snoRNA 3-end processing|
|cytoplasmic exosome (RNase complex)|
|DNA deamination|
|nuclear RNA surveillance|
|exoribonuclease activity|
|snoRNA processing|
|nuclear mRNA surveillance|
|RNA surveillance|
|nuclear exosome (RNase complex)|
|snoRNA metabolic process|
|exosome (RNase complex)|
|somatic diversification of immunoglobulins involved in immune response|
|isotype switching|
|somatic recombination of immunoglobulin genes involved in immune response|
|rRNA catabolic process|
|somatic recombination of immunoglobulin gene segments|
|positive regulation of isotype switching|
|immunoglobulin production involved in immunoglobulin mediated immune response|
|ncRNA catabolic process|
|snRNA 3-end processing|
|regulation of isotype switching|
|exonucleolytic catabolism of deadenylated mRNA|
|nuclear-transcribed mRNA catabolic process, exonucleolytic|
|somatic cell DNA recombination|
|somatic diversification of immune receptors via germline recombination within a single locus|
|snRNA processing|
|somatic diversification of immunoglobulins|
|positive regulation of B cell mediated immunity|
|positive regulation of immunoglobulin mediated immune response|
|positive regulation of DNA recombination|
|RNA phosphodiester bond hydrolysis, exonucleolytic|
|snRNA metabolic process|
|positive regulation of immunoglobulin production|
|B cell activation involved in immune response|
|ncRNA 3-end processing|
|somatic diversification of immune receptors|
|regulation of immunoglobulin mediated immune response|
|regulation of B cell mediated immunity|
|nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay|
|regulation of immunoglobulin production|
|DNA modification|
|positive regulation of production of molecular mediator of immune response|
|positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|regulation of DNA recombination|
|positive regulation of lymphocyte mediated immunity|
|positive regulation of adaptive immune response|
|lymphocyte activation involved in immune response|
|positive regulation of leukocyte mediated immunity|
|RNA 3-end processing|
|regulation of production of molecular mediator of immune response|
|regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|regulation of lymphocyte mediated immunity|
|B cell activation|
|immunoglobulin production|
|RNA phosphodiester bond hydrolysis|
|regulation of adaptive immune response|
|positive regulation of B cell activation|
|regulation of mRNA stability|
|production of molecular mediator of immune response|
|regulation of RNA stability|
|positive regulation of DNA metabolic process|
|nuclear-transcribed mRNA catabolic process|
|regulation of mRNA catabolic process|
|regulation of leukocyte mediated immunity|
|immunoglobulin mediated immune response|
|regulation of B cell activation|
|B cell mediated immunity|
|rRNA processing|
|mRNA catabolic process|
|positive regulation of immune effector process|
|DNA recombination|
|rRNA metabolic process|
|RNA catabolic process|
|lymphocyte mediated immunity|
|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|nucleic acid phosphodiester bond hydrolysis|
|ribosome biogenesis|
|regulation of mRNA metabolic process|
|regulation of DNA metabolic process|
|positive regulation of lymphocyte activation|
|nucleobase-containing compound catabolic process|
|lymphocyte activation|
|ncRNA processing|
|positive regulation of leukocyte activation|
|positive regulation of cell activation|
|heterocycle catabolic process|
|cellular nitrogen compound catabolic process|
|aromatic compound catabolic process|
|ribonucleoprotein complex biogenesis|
|regulation of immune effector process|
|ncRNA metabolic process|
|organic cyclic compound catabolic process|
|regulation of lymphocyte activation|
|posttranscriptional regulation of gene expression|
|regulation of leukocyte activation|
|adaptive immune response|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|regulation of cell activation|
|immune system development|
|mRNA metabolic process|
|DNA metabolic process|
|leukocyte mediated immunity|
|regulation of cellular catabolic process|
|nucleolus|
|positive regulation of immune response|
|RNA processing|
|cellular macromolecule catabolic process|
|leukocyte activation|
|regulation of catabolic process|
|macromolecule catabolic process|
|cell activation|
|immune effector process|
|positive regulation of immune system process|
|regulation of immune response|
|positive regulation of developmental process|
|RNA binding|
|regulation of immune system process|
|RNA metabolic process|
|negative regulation of gene expression|
|positive regulation of multicellular organismal process|
|organic substance catabolic process|
|cellular catabolic process|
|immune response|
|positive regulation of nucleobase-containing compound metabolic process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp282|Fluvastatin 2.2μM R06 exp282]]|-2.71|
|[[:results:exp256|HMS-I1 10μM R06 exp256]]|-2.48|
|[[:results:exp17|DABN 20μM R00 exp17]]|-2.29|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|-2.21|
|[[:results:exp93|DABN racemic mixture R03 exp93]]|-1.94|
|[[:results:exp4|Actinomycin-D 0.01μM R00 exp4]]|-1.91|
|[[:results:exp98|BI-6727 0.04μM R03 exp98]]|-1.84|
|[[:results:exp244|SB743921 0.001μM R05 exp244]]|-1.84|
|[[:results:exp208|Vinblastine 0.015μM R05 exp208]]|-1.71|
|[[:results:exp24|Nocodazole 0.2μM R00 exp24]]|-1.7|
|[[:results:exp405|Tenofovir 10μM R07 exp405]]|1.74|
|[[:results:exp528|TGF-beta1 44ng/ml R08 exp528]]|1.75|
|[[:results:exp140|Nicotinate 1000μM R03 exp140]]|1.79|
|[[:results:exp535|Trimetrexate 0.03μM R08 exp535]]|1.79|
|[[:results:exp422|Wiskostatin 3μM R07 exp422]]|1.81|
|[[:results:exp169|BH1 1μM R04 exp169]]|1.82|
|[[:results:exp235|Geldanamycin 0.01μM R05 exp235]]|1.86|
|[[:results:exp308|Rapamycin 2μM plus FK-506 5μM R07 exp308]]|1.89|
|[[:results:exp400|Senexin-A 25μM R07 exp400]]|1.89|
|[[:results:exp399|Salubrinal 20μM R07 exp399]]|1.9|
|[[:results:exp73|LJH685 5μM R02 exp73]]|1.92|
|[[:results:exp510|Nicotine 3000μM R08 exp510]]|2.12|
|[[:results:exp246|UM0011500 10μM R05 exp246]]|2.18|
|[[:results:exp455|Benzoate 10000μM R08 exp455]]|2.21|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:prim1|PRIM1]]|0.554|
|[[:human genes:p:psmb4|PSMB4]]|0.528|
|[[:human genes:p:psmb3|PSMB3]]|0.512|
|[[:human genes:p:pola1|POLA1]]|0.498|
|[[:human genes:c:chd4|CHD4]]|0.495|
|[[:human genes:w:wdr75|WDR75]]|0.486|
|[[:human genes:t:tyms|TYMS]]|0.484|
|[[:human genes:t:tceb3c|TCEB3C]]|0.481|
|[[:human genes:r:rrp7a|RRP7A]]|0.478|
|[[:human genes:p:psmc2|PSMC2]]|0.472|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.464|
|[[:human genes:c:ccna2|CCNA2]]|0.464|
|[[:human genes:r:rps2|RPS2]]|0.461|
|[[:human genes:n:nsf|NSF]]|0.461|
|[[:human genes:r:rpl35|RPL35]]|0.458|
|[[:human genes:p:psmb2|PSMB2]]|0.457|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.456|
|[[:human genes:n:nol9|NOL9]]|0.454|
|[[:human genes:n:nol12|NOL12]]|0.453|
|[[:human genes:u:utp3|UTP3]]|0.45|
|[[:human genes:t:tp53tg3b|TP53TG3B]]|0.449|
|[[:human genes:z:znf148|ZNF148]]|0.449|
|[[:human genes:k:krt78|KRT78]]|0.449|
|[[:human genes:t:tp53tg3c|TP53TG3C]]|0.449|
|[[:human genes:t:tp53tg3|TP53TG3]]|0.449|
|[[:human genes:a:aamp|AAMP]]|0.448|
|[[:human genes:o:orc6|ORC6]]|0.448|
|[[:human genes:a:atp6v1b2|ATP6V1B2]]|0.447|
|[[:human genes:c:cactin|CACTIN]]|0.446|
|[[:human genes:m:mt1e|MT1E]]|0.446|
|[[:human genes:p:polr2j3|POLR2J3]]|0.445|
|[[:human genes:p:psmd14|PSMD14]]|0.444|
|[[:human genes:d:dock6|DOCK6]]|0.444|
|[[:human genes:n:narfl|NARFL]]|0.442|
|[[:human genes:p:pola2|POLA2]]|0.442|
|[[:human genes:a:arcn1|ARCN1]]|0.442|
|[[:human genes:e:eif4a3|EIF4A3]]|0.441|
|[[:human genes:i:iscu|ISCU]]|0.441|
|[[:human genes:i:ik|IK]]|0.44|
|[[:human genes:p:paf1|PAF1]]|0.439|
|[[:human genes:a:ankle2|ANKLE2]]|0.438|
|[[:human genes:t:tbc1d3c|TBC1D3C]]|0.436|
|[[:human genes:c:ccdc116|CCDC116]]|0.435|
|[[:human genes:t:tsg101|TSG101]]|0.435|
|[[:human genes:m:mtch2|MTCH2]]|0.434|
|[[:human genes:r:ranbp2|RANBP2]]|0.432|
|[[:human genes:n:npipb5|NPIPB5]]|0.432|
|[[:human genes:k:kif3c|KIF3C]]|0.429|
|[[:human genes:v:vps28|VPS28]]|0.428|
|[[:human genes:s:slc6a17|SLC6A17]]|0.426|
|[[:human genes:a:atp6v1c1|ATP6V1C1]]|0.425|
|[[:human genes:c:ctage4|CTAGE4]]|0.424|
|[[:human genes:c:cgb2|CGB2]]|0.424|
|[[:human genes:s:supt5h|SUPT5H]]|0.423|
|[[:human genes:a:atp6v1a|ATP6V1A]]|0.422|
|[[:human genes:d:ddtl|DDTL]]|0.42|
|[[:human genes:s:sf3a1|SF3A1]]|0.42|
|[[:human genes:p:pole|POLE]]|0.419|
|[[:human genes:s:snip1|SNIP1]]|0.416|
|[[:human genes:s:snrpb|SNRPB]]|0.416|
|[[:human genes:p:psma6|PSMA6]]|0.415|
|[[:human genes:t:tinf2|TINF2]]|0.414|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.414|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.413|
|[[:human genes:n:napa|NAPA]]|0.413|
|[[:human genes:r:rbm48|RBM48]]|0.412|
|[[:human genes:n:nup160|NUP160]]|0.411|
|[[:human genes:d:dhx38|DHX38]]|0.41|
|[[:human genes:d:disp2|DISP2]]|0.41|
|[[:human genes:h:hgc6.3|HGC6.3]]|0.41|
|[[:human genes:c:cep192|CEP192]]|0.41|
|[[:human genes:g:golga8o|GOLGA8O]]|0.409|
|[[:human genes:m:myt1l|MYT1L]]|0.409|
|[[:human genes:s:snrnp70|SNRNP70]]|0.408|
|[[:human genes:h:hivep3|HIVEP3]]|0.408|
|[[:human genes:p:psmb1|PSMB1]]|0.407|
|[[:human genes:u:upf1|UPF1]]|0.407|
|[[:human genes:k:kctd17|KCTD17]]|0.406|
|[[:human genes:r:rpl6|RPL6]]|0.404|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.403|
|[[:human genes:c:col2a1|COL2A1]]|0.403|
|[[:human genes:a:akirin2|AKIRIN2]]|0.402|
|[[:human genes:a:ankle1|ANKLE1]]|0.402|
|[[:human genes:c:cdca3|CDCA3]]|0.401|
|[[:human genes:c:cope|COPE]]|0.401|
|[[:human genes:c:c14orf93|C14orf93]]|0.401|
|[[:human genes:o:or10g3|OR10G3]]|0.401|
|[[:human genes:t:timeless|TIMELESS]]|0.4|
|[[:human genes:l:lad1|LAD1]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 688/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|28/28|
|blood|27/28|
|bone|25/26|
|breast|29/33|
|central nervous system|53/56|
|cervix|4/4|
|colorectal|16/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|14/16|
|kidney|21/21|
|liver|19/20|
|lung|68/75|
|lymphocyte|15/16|
|ovary|24/26|
|pancreas|24/24|
|peripheral nervous system|15/16|
|plasma cell|15/15|
|prostate|1/1|
|skin|23/24|
|soft tissue|9/9|
|thyroid|2/2|
|upper aerodigestive|21/22|
|urinary tract|25/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 568
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.17 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='EXOSC6 Expression in NALM6 Cells: 7.17'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>