======= EXOSC9 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: EXOSC9
  * **<color #00a2e8>Official Name</color>**: exosome component 9
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5393|5393]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q06265|Q06265]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=EXOSC9&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20EXOSC9|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606180|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a component of the human exosome, a exoribonuclease complex which processes and degrades RNA in the nucleus and cytoplasm. This component may play a role in mRNA degradation and the polymyositis/scleroderma autoantigen complex. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC9 binds to ARE-containing RNAs. {ECO:0000269|PubMed:11782436, ECO:0000269|PubMed:16455498, ECO:0000269|PubMed:16912217, ECO:0000269|PubMed:17545563}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|RNase PH|
|RNase PH C|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|U1 snRNA 3-end processing|
|U5 snRNA 3-end processing|
|polyadenylation-dependent mRNA catabolic process|
|nuclear polyadenylation-dependent mRNA catabolic process|
|nuclear polyadenylation-dependent ncRNA catabolic process|
|nuclear polyadenylation-dependent tRNA catabolic process|
|nuclear polyadenylation-dependent rRNA catabolic process|
|nuclear ncRNA surveillance|
|AU-rich element binding|
|polyadenylation-dependent ncRNA catabolic process|
|exonucleolytic trimming involved in rRNA processing|
|U4 snRNA 3-end processing|
|tRNA catabolic process|
|polyadenylation-dependent RNA catabolic process|
|exonucleolytic trimming to generate mature 3-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|
|rRNA 3-end processing|
|nuclear-transcribed mRNA catabolic process, exonucleolytic, 3-5|
|cytoplasmic exosome (RNase complex)|
|nuclear mRNA surveillance|
|exoribonuclease activity|
|nuclear RNA surveillance|
|RNA surveillance|
|nuclear exosome (RNase complex)|
|exosome (RNase complex)|
|rRNA catabolic process|
|maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|
|cleavage involved in rRNA processing|
|mRNA 3-UTR AU-rich region binding|
|maturation of 5.8S rRNA|
|nuclear chromosome|
|ncRNA catabolic process|
|snRNA 3-end processing|
|3-5-exoribonuclease activity|
|exonucleolytic catabolism of deadenylated mRNA|
|nuclear-transcribed mRNA catabolic process, exonucleolytic|
|snRNA processing|
|RNA phosphodiester bond hydrolysis, exonucleolytic|
|snRNA metabolic process|
|ncRNA 3-end processing|
|RNA polymerase II activating transcription factor binding|
|nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay|
|RNA 3-end processing|
|RNA phosphodiester bond hydrolysis|
|positive regulation of cell growth|
|regulation of mRNA stability|
|regulation of RNA stability|
|tRNA metabolic process|
|nuclear-transcribed mRNA catabolic process|
|regulation of mRNA catabolic process|
|rRNA processing|
|mRNA catabolic process|
|rRNA metabolic process|
|RNA catabolic process|
|positive regulation of growth|
|nucleic acid phosphodiester bond hydrolysis|
|ribosome biogenesis|
|regulation of mRNA metabolic process|
|nucleobase-containing compound catabolic process|
|ncRNA processing|
|regulation of cell growth|
|heterocycle catabolic process|
|cellular nitrogen compound catabolic process|
|aromatic compound catabolic process|
|ribonucleoprotein complex biogenesis|
|ncRNA metabolic process|
|organic cyclic compound catabolic process|
|posttranscriptional regulation of gene expression|
|modification-dependent macromolecule catabolic process|
|regulation of growth|
|mRNA metabolic process|
|regulation of cellular catabolic process|
|nucleolus|
|RNA processing|
|cellular macromolecule catabolic process|
|regulation of catabolic process|
|macromolecule catabolic process|
|positive regulation of transcription by RNA polymerase II|
|RNA binding|
|positive regulation of transcription, DNA-templated|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|RNA metabolic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|organic substance catabolic process|
|cellular catabolic process|
|immune response|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|-2|
|[[:results:exp77|Prochlorperazine 5.2μM R02 exp77]]|1.72|
|[[:results:exp406|Thalidomide 20μM R07 exp406]]|1.8|
|[[:results:exp224|CB-839 10μM R05 exp224]]|1.81|
|[[:results:exp533|TNF-alpha 44ng/ml R08 exp533]]|1.83|
|[[:results:exp376|Losmapimod 1μM R07 exp376]]|1.94|
|[[:results:exp438|NN-Diethyl-meta-toluamide 500μM R08 exp438]]|2.02|
|[[:results:exp232|Epothilone-D 0.004 to 0.006μM on day4 R05 exp232]]|2.23|
|[[:results:exp473|Cincreasin 100μM R08 exp473]]|2.29|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:g:golga6l1|GOLGA6L1]]|0.579|
|[[:human genes:r:rpl35|RPL35]]|0.564|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.551|
|[[:human genes:c:chd4|CHD4]]|0.547|
|[[:human genes:c:cbwd6|CBWD6]]|0.546|
|[[:human genes:c:cbwd3|CBWD3]]|0.544|
|[[:human genes:p:psmb4|PSMB4]]|0.54|
|[[:human genes:t:tceb3c|TCEB3C]]|0.535|
|[[:human genes:p:psmb2|PSMB2]]|0.518|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.515|
|[[:human genes:v:vps28|VPS28]]|0.514|
|[[:human genes:c:cbwd5|CBWD5]]|0.512|
|[[:human genes:m:myo1h|MYO1H]]|0.509|
|[[:human genes:v:vasn|VASN]]|0.506|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.505|
|[[:human genes:c:ccdc116|CCDC116]]|0.499|
|[[:human genes:s:supt5h|SUPT5H]]|0.498|
|[[:human genes:p:polr2d|POLR2D]]|0.497|
|[[:human genes:c:ccna2|CCNA2]]|0.496|
|[[:human genes:c:copg1|COPG1]]|0.496|
|[[:human genes:w:wdr75|WDR75]]|0.494|
|[[:human genes:n:napa|NAPA]]|0.493|
|[[:human genes:c:cdh24|CDH24]]|0.491|
|[[:human genes:n:narfl|NARFL]]|0.491|
|[[:human genes:p:paf1|PAF1]]|0.49|
|[[:human genes:c:c14orf93|C14orf93]]|0.489|
|[[:human genes:i:ik|IK]]|0.488|
|[[:human genes:p:pan3|PAN3]]|0.487|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.486|
|[[:human genes:r:rnpc3|RNPC3]]|0.485|
|[[:human genes:z:zfand5|ZFAND5]]|0.485|
|[[:human genes:c:col2a1|COL2A1]]|0.484|
|[[:human genes:c:chaf1a|CHAF1A]]|0.484|
|[[:human genes:k:krt78|KRT78]]|0.484|
|[[:human genes:t:ticrr|TICRR]]|0.483|
|[[:human genes:p:psma6|PSMA6]]|0.483|
|[[:human genes:a:atp6v1b2|ATP6V1B2]]|0.481|
|[[:human genes:p:psmc5|PSMC5]]|0.479|
|[[:human genes:a:ankle1|ANKLE1]]|0.479|
|[[:human genes:u:utp20|UTP20]]|0.478|
|[[:human genes:a:ankle2|ANKLE2]]|0.475|
|[[:human genes:k:kctd17|KCTD17]]|0.475|
|[[:human genes:t:tbc1d3i|TBC1D3I]]|0.474|
|[[:human genes:t:tbc1d3e|TBC1D3E]]|0.473|
|[[:human genes:p:psma7|PSMA7]]|0.472|
|[[:human genes:t:tbc1d3l|TBC1D3L]]|0.471|
|[[:human genes:t:tbc1d3k|TBC1D3K]]|0.471|
|[[:human genes:d:dtl|DTL]]|0.469|
|[[:human genes:t:tp53tg3d|TP53TG3D]]|0.468|
|[[:human genes:t:tbc1d3|TBC1D3]]|0.468|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.465|
|[[:human genes:t:tbc1d3c|TBC1D3C]]|0.463|
|[[:human genes:m:mbtd1|MBTD1]]|0.463|
|[[:human genes:r:rad51|RAD51]]|0.463|
|[[:human genes:g:gid4|GID4]]|0.462|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.458|
|[[:human genes:k:kpnb1|KPNB1]]|0.455|
|[[:human genes:s:slc4a1|SLC4A1]]|0.453|
|[[:human genes:c:cgb2|CGB2]]|0.453|
|[[:human genes:r:rrp7a|RRP7A]]|0.452|
|[[:human genes:c:ccdc64b|CCDC64B]]|0.451|
|[[:human genes:u:utp3|UTP3]]|0.451|
|[[:human genes:z:znf574|ZNF574]]|0.45|
|[[:human genes:t:tspy8|TSPY8]]|0.447|
|[[:human genes:e:ebna1bp2|EBNA1BP2]]|0.447|
|[[:human genes:t:tyms|TYMS]]|0.447|
|[[:human genes:c:copb1|COPB1]]|0.444|
|[[:human genes:b:bysl|BYSL]]|0.443|
|[[:human genes:s:sart1|SART1]]|0.443|
|[[:human genes:m:mt1e|MT1E]]|0.442|
|[[:human genes:e:exosc4|EXOSC4]]|0.442|
|[[:human genes:s:sap30bp|SAP30BP]]|0.441|
|[[:human genes:r:rpl6|RPL6]]|0.44|
|[[:human genes:r:rps7|RPS7]]|0.44|
|[[:human genes:l:lrr1|LRR1]]|0.44|
|[[:human genes:c:cdt1|CDT1]]|0.438|
|[[:human genes:c:cep192|CEP192]]|0.438|
|[[:human genes:a:aqr|AQR]]|0.438|
|[[:human genes:n:nsf|NSF]]|0.438|
|[[:human genes:d:dock6|DOCK6]]|0.436|
|[[:human genes:x:xab2|XAB2]]|0.435|
|[[:human genes:p:pole|POLE]]|0.435|
|[[:human genes:f:fam20a|FAM20A]]|0.435|
|[[:human genes:s:smg7|SMG7]]|0.434|
|[[:human genes:o:ogfr|OGFR]]|0.434|
|[[:human genes:p:prpf19|PRPF19]]|0.434|
|[[:human genes:c:cdc45|CDC45]]|0.432|
|[[:human genes:m:myo18a|MYO18A]]|0.432|
|[[:human genes:c:cactin|CACTIN]]|0.431|
|[[:human genes:p:pola1|POLA1]]|0.43|
|[[:human genes:n:nup160|NUP160]]|0.429|
|[[:human genes:d:dnttip2|DNTTIP2]]|0.429|
|[[:human genes:d:disp2|DISP2]]|0.429|
|[[:human genes:o:orc1|ORC1]]|0.429|
|[[:human genes:r:ranbp2|RANBP2]]|0.429|
|[[:human genes:n:npipb5|NPIPB5]]|0.429|
|[[:human genes:k:kiaa0947|KIAA0947]]|0.428|
|[[:human genes:s:sh3bp1|SH3BP1]]|0.428|
|[[:human genes:c:ctage4|CTAGE4]]|0.428|
|[[:human genes:a:arcn1|ARCN1]]|0.427|
|[[:human genes:m:myh7b|MYH7B]]|0.426|
|[[:human genes:c:cln6|CLN6]]|0.426|
|[[:human genes:t:timeless|TIMELESS]]|0.426|
|[[:human genes:t:tfip11|TFIP11]]|0.426|
|[[:human genes:l:loc643669|LOC643669]]|0.425|
|[[:human genes:s:supt6h|SUPT6H]]|0.425|
|[[:human genes:a:atp6v1a|ATP6V1A]]|0.425|
|[[:human genes:d:ddx47|DDX47]]|0.425|
|[[:human genes:c:cdc73|CDC73]]|0.424|
|[[:human genes:r:rps2|RPS2]]|0.423|
|[[:human genes:p:polr2h|POLR2H]]|0.422|
|[[:human genes:s:smg1|SMG1]]|0.422|
|[[:human genes:d:ddtl|DDTL]]|0.421|
|[[:human genes:t:twistnb|TWISTNB]]|0.42|
|[[:human genes:s:ssh2|SSH2]]|0.419|
|[[:human genes:p:plk1|PLK1]]|0.419|
|[[:human genes:p:psmc3|PSMC3]]|0.418|
|[[:human genes:x:xylt2|XYLT2]]|0.418|
|[[:human genes:e:exosc3|EXOSC3]]|0.416|
|[[:human genes:z:zmat5|ZMAT5]]|0.416|
|[[:human genes:p:psmd2|PSMD2]]|0.416|
|[[:human genes:i:igfn1|IGFN1]]|0.416|
|[[:human genes:e:exosc5|EXOSC5]]|0.416|
|[[:human genes:o:or10g3|OR10G3]]|0.415|
|[[:human genes:n:nol10|NOL10]]|0.415|
|[[:human genes:p:psmd7|PSMD7]]|0.414|
|[[:human genes:n:ngdn|NGDN]]|0.414|
|[[:human genes:d:diexf|DIEXF]]|0.414|
|[[:human genes:p:ppm1d|PPM1D]]|0.414|
|[[:human genes:d:ddx56|DDX56]]|0.414|
|[[:human genes:i:ints5|INTS5]]|0.413|
|[[:human genes:r:rps12|RPS12]]|0.413|
|[[:human genes:f:fam231c|FAM231C]]|0.412|
|[[:human genes:f:fam231a|FAM231A]]|0.412|
|[[:human genes:r:rpl30|RPL30]]|0.412|
|[[:human genes:s:slc6a17|SLC6A17]]|0.412|
|[[:human genes:g:golga8o|GOLGA8O]]|0.412|
|[[:human genes:r:rps10|RPS10]]|0.411|
|[[:human genes:p:psmd3|PSMD3]]|0.411|
|[[:human genes:s:scgb1c1|SCGB1C1]]|0.411|
|[[:human genes:n:nup85|NUP85]]|0.411|
|[[:human genes:z:znf830|ZNF830]]|0.411|
|[[:human genes:m:mtch2|MTCH2]]|0.41|
|[[:human genes:s:snip1|SNIP1]]|0.41|
|[[:human genes:m:mdm2|MDM2]]|0.409|
|[[:human genes:u:upf1|UPF1]]|0.409|
|[[:human genes:f:fam86b2|FAM86B2]]|0.409|
|[[:human genes:c:chmp4b|CHMP4B]]|0.409|
|[[:human genes:r:rps19|RPS19]]|0.408|
|[[:human genes:r:rrp15|RRP15]]|0.408|
|[[:human genes:m:mfsd12|MFSD12]]|0.407|
|[[:human genes:p:psmc1|PSMC1]]|0.407|
|[[:human genes:p:polr2l|POLR2L]]|0.407|
|[[:human genes:f:fam25b|FAM25B]]|0.406|
|[[:human genes:m:mepce|MEPCE]]|0.406|
|[[:human genes:t:trappc11|TRAPPC11]]|0.405|
|[[:human genes:b:brix1|BRIX1]]|0.404|
|[[:human genes:p:psmd11|PSMD11]]|0.404|
|[[:human genes:n:nop16|NOP16]]|0.402|
|[[:human genes:p:pwp2|PWP2]]|0.401|
|[[:human genes:i:il2rb|IL2RB]]|0.401|
|[[:human genes:t:tspy2|TSPY2]]|0.401|
|[[:human genes:h:hist2h3a|HIST2H3A]]|0.401|
|[[:human genes:c:chmp2a|CHMP2A]]|0.401|
|[[:human genes:h:hist2h3c|HIST2H3C]]|0.4|
|[[:human genes:p:psmd1|PSMD1]]|0.4|
|[[:human genes:r:rpl8|RPL8]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 12/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|2/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|3/16|
|ovary|1/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|1/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|1/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|1/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1677
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.27 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='EXOSC9 Expression in NALM6 Cells: 7.27'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>