======= F5 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: F5
  * **<color #00a2e8>Official Name</color>**: coagulation factor V
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2153|2153]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P12259|P12259]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=F5&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20F5|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/612309|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes an essential cofactor of the blood coagulation cascade. This factor circulates in plasma, and is converted to the active form by the release of the activation peptide by thrombin during coagulation. This generates a heavy chain and a light chain which are held together by calcium ions. The activated protein is a cofactor that participates with activated coagulation factor X to activate prothrombin to thrombin. Defects in this gene result in either an autosomal recessive hemorrhagic diathesis or an autosomal dominant form of thrombophilia, which is known as activated protein C resistance. [provided by RefSeq, Oct 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Central regulator of hemostasis. It serves as a critical cofactor for the prothrombinase activity of factor Xa that results in the activation of prothrombin to thrombin.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Cu-oxidase 3|
|F5 F8 type C|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|COPII-coated ER to Golgi transport vesicle|
|extracellular vesicle|
|copper ion binding|
|vesicle targeting, rough ER to cis-Golgi|
|COPII vesicle coating|
|platelet alpha granule lumen|
|vesicle coating|
|COPII-coated vesicle budding|
|vesicle targeting, to, from or within Golgi|
|endoplasmic reticulum-Golgi intermediate compartment membrane|
|Golgi vesicle budding|
|vesicle targeting|
|vesicle budding from membrane|
|platelet degranulation|
|establishment of vesicle localization|
|vesicle localization|
|endoplasmic reticulum to Golgi vesicle-mediated transport|
|blood coagulation|
|coagulation|
|hemostasis|
|vesicle organization|
|endoplasmic reticulum lumen|
|post-translational protein modification|
|establishment of organelle localization|
|Golgi vesicle transport|
|blood circulation|
|circulatory system process|
|wound healing|
|regulation of body fluid levels|
|response to wounding|
|organelle localization|
|Golgi membrane|
|regulated exocytosis|
|exocytosis|
|membrane organization|
|secretion by cell|
|export from cell|
|secretion|
|intracellular transport|
|protein-containing complex assembly|
|extracellular space|
|establishment of localization in cell|
|protein-containing complex subunit organization|
|extracellular region|
|vesicle-mediated transport|
|system process|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|-1.95|
|[[:results:exp175|3-Bromopyruvate 7μM R04 exp175]]|1.81|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13632
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -6.6 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='F5 Expression in NALM6 Cells: -6.6'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>