======= F8 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: F8
  * **<color #00a2e8>Official Name</color>**: coagulation factor VIII
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2157|2157]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P00451|P00451]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=F8&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20F8|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/300841|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes coagulation factor VIII, which participates in the intrinsic pathway of blood coagulation; factor VIII is a cofactor for factor IXa which, in the presence of Ca+2 and phospholipids, converts factor X to the activated form Xa. This gene produces two alternatively spliced transcripts. Transcript variant 1 encodes a large glycoprotein, isoform a, which circulates in plasma and associates with von Willebrand factor in a noncovalent complex. This protein undergoes multiple cleavage events. Transcript variant 2 encodes a putative small protein, isoform b, which consists primarily of the phospholipid binding domain of factor VIIIc. This binding domain is essential for coagulant activity. Defects in this gene results in hemophilia A, a common recessive X-linked coagulation disorder. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Factor VIII, along with calcium and phospholipid, acts as a cofactor for F9/factor IXa when it converts F10/factor X to the activated form, factor Xa.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|F5 F8 type C|
|Cu-oxidase 2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|blood coagulation, intrinsic pathway|
|blood coagulation, fibrin clot formation|
|protein activation cascade|
|acute-phase response|
|COPII-coated ER to Golgi transport vesicle|
|copper ion binding|
|vesicle targeting, rough ER to cis-Golgi|
|COPII vesicle coating|
|platelet alpha granule lumen|
|vesicle coating|
|COPII-coated vesicle budding|
|vesicle targeting, to, from or within Golgi|
|acute inflammatory response|
|endoplasmic reticulum-Golgi intermediate compartment membrane|
|Golgi vesicle budding|
|vesicle targeting|
|vesicle budding from membrane|
|oxidoreductase activity|
|platelet degranulation|
|platelet activation|
|establishment of vesicle localization|
|vesicle localization|
|endoplasmic reticulum to Golgi vesicle-mediated transport|
|blood coagulation|
|coagulation|
|hemostasis|
|vesicle organization|
|endoplasmic reticulum lumen|
|establishment of organelle localization|
|Golgi vesicle transport|
|wound healing|
|regulation of body fluid levels|
|inflammatory response|
|response to wounding|
|organelle localization|
|Golgi membrane|
|regulated exocytosis|
|exocytosis|
|membrane organization|
|oxidation-reduction process|
|secretion by cell|
|export from cell|
|cell activation|
|secretion|
|defense response|
|intracellular transport|
|protein-containing complex assembly|
|extracellular space|
|establishment of localization in cell|
|protein-containing complex subunit organization|
|extracellular region|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp133|MKC9989 10μM R03 exp133]]|1.91|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/694
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/26|
|bone|0/26|
|breast|0/30|
|central nervous system|0/49|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/11|
|fibroblast|0/1|
|gastric|0/14|
|kidney|0/18|
|liver|0/19|
|lung|0/72|
|lymphocyte|0/16|
|ovary|0/25|
|pancreas|0/22|
|peripheral nervous system|0/15|
|plasma cell|0/12|
|prostate|0/1|
|skin|0/20|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/28|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 18395
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.87 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='F8 Expression in NALM6 Cells: 0.87'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>