======= F8A1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: F8A1
  * **<color #00a2e8>Official Name</color>**: coagulation factor VIII associated 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8263|8263]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P23610|P23610]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=F8A1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20F8A1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/305423|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Not known. Possible housekeeping role.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|molecular function|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp470|Chloroquine 32μM R08 exp470]]|-2.47|
|[[:results:exp454|Bafilomycin-A1 0.009μM R08 exp454]]|-2.4|
|[[:results:exp68|Clomiphene 4.4μM R02 exp68]]|-2.38|
|[[:results:exp169|BH1 1μM R04 exp169]]|-2.12|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|-1.92|
|[[:results:exp175|3-Bromopyruvate 7μM R04 exp175]]|1.77|
|[[:results:exp242|Radicicol 0.16μM R05 exp242]]|1.9|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:htt|HTT]]|0.602|
|[[:human genes:h:hgc6.3|HGC6.3]]|0.402|
|[[:human genes:t:tbc1d23|TBC1D23]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 14/694
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|1/28|
|blood|1/26|
|bone|0/26|
|breast|2/30|
|central nervous system|0/49|
|cervix|0/4|
|colorectal|1/17|
|esophagus|0/11|
|fibroblast|0/1|
|gastric|1/14|
|kidney|0/18|
|liver|0/19|
|lung|1/72|
|lymphocyte|0/16|
|ovary|0/25|
|pancreas|0/22|
|peripheral nervous system|0/15|
|plasma cell|0/12|
|prostate|0/1|
|skin|1/20|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|2/22|
|urinary tract|0/28|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3109
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.49 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='F8A1 Expression in NALM6 Cells: 3.49'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>