======= FABP2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: FABP2
  * **<color #00a2e8>Official Name</color>**: fatty acid binding protein 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2169|2169]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P12104|P12104]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=FABP2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20FABP2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/134640|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is an intracellular fatty acid-binding protein that participates in the uptake, intracellular metabolism, and transport of long-chain fatty acids. The encoded protein is also involved in the modulation of cell growth and proliferation. This protein binds saturated long-chain fatty acids with high affinity, and may act as a lipid sensor to maintain energy homeostasis. [provided by RefSeq, Aug 2017]. 
  * **<color #00a2e8>UniProt Summary</color>**:  FABP are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters. FABP2 is probably involved in triglyceride-rich lipoprotein synthesis. Binds saturated long-chain fatty acids with a high affinity, but binds with a lower affinity to unsaturated long- chain fatty acids. FABP2 may also help maintain energy homeostasis by functioning as a lipid sensor.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Lipocalin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|long-chain fatty acid binding|
|intestinal lipid absorption|
|fatty acid binding|
|triglyceride catabolic process|
|intestinal absorption|
|neutral lipid catabolic process|
|acylglycerol catabolic process|
|glycerolipid catabolic process|
|digestive system process|
|triglyceride metabolic process|
|acylglycerol metabolic process|
|neutral lipid metabolic process|
|digestion|
|cellular lipid catabolic process|
|lipid transport|
|lipid catabolic process|
|lipid localization|
|glycerolipid metabolic process|
|cellular lipid metabolic process|
|lipid metabolic process|
|organic substance catabolic process|
|cellular catabolic process|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp291|LLY-284 2.6μM R06 exp291]]|1.75|
|[[:results:exp392|PT-1 25μM R07 exp392]]|1.86|
|[[:results:exp81|Selumetinib 20μM R02 exp81]]|2.05|
|[[:results:exp301|VER-155008 3.9μM R06 exp301]]|2.28|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10329
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.25 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='FABP2 Expression in NALM6 Cells: 1.25'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>