======= FABP3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: FABP3
  * **<color #00a2e8>Official Name</color>**: fatty acid binding protein 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2170|2170]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P05413|P05413]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=FABP3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20FABP3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/134651|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The intracellular fatty acid-binding proteins (FABPs) belongs to a multigene family. FABPs are divided into at least three distinct types, namely the hepatic-, intestinal- and cardiac-type. They form 14-15 kDa proteins and are thought to participate in the uptake, intracellular metabolism and/or transport of long-chain fatty acids. They may also be responsible in the modulation of cell growth and proliferation. Fatty acid-binding protein 3 gene contains four exons and its function is to arrest growth of mammary epithelial cells. This gene is a candidate tumor suppressor gene for human breast cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**:  FABP are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Lipocalin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of long-chain fatty acid import into cell|
|icosatetraenoic acid binding|
|oleic acid binding|
|regulation of phosphatidylcholine biosynthetic process|
|regulation of long-chain fatty acid import into cell|
|long-chain fatty acid binding|
|sarcoplasm|
|phospholipid homeostasis|
|long-chain fatty acid transporter activity|
|positive regulation of phospholipid biosynthetic process|
|regulation of phospholipid biosynthetic process|
|positive regulation of fatty acid transport|
|triglyceride catabolic process|
|regulation of fatty acid transport|
|regulation of fatty acid oxidation|
|positive regulation of organic acid transport|
|neutral lipid catabolic process|
|acylglycerol catabolic process|
|intracellular lipid transport|
|positive regulation of phospholipid metabolic process|
|positive regulation of anion transport|
|glycerolipid catabolic process|
|anion homeostasis|
|regulation of organic acid transport|
|long-chain fatty acid transport|
|positive regulation of lipid transport|
|fatty acid transport|
|triglyceride metabolic process|
|cytoskeletal protein binding|
|positive regulation of lipid biosynthetic process|
|cholesterol homeostasis|
|sterol homeostasis|
|positive regulation of lipid localization|
|regulation of phospholipid metabolic process|
|response to fatty acid|
|regulation of fatty acid metabolic process|
|regulation of anion transport|
|acylglycerol metabolic process|
|neutral lipid metabolic process|
|regulation of lipid transport|
|lipid homeostasis|
|monocarboxylic acid transport|
|regulation of lipid localization|
|positive regulation of lipid metabolic process|
|regulation of cellular ketone metabolic process|
|regulation of lipid biosynthetic process|
|cellular lipid catabolic process|
|response to insulin|
|positive regulation of ion transport|
|organic acid transport|
|carboxylic acid transport|
|lipid transport|
|lipid catabolic process|
|lipid localization|
|fatty acid metabolic process|
|response to acid chemical|
|glycerolipid metabolic process|
|response to peptide hormone|
|regulation of lipid metabolic process|
|regulation of small molecule metabolic process|
|organic anion transport|
|response to peptide|
|monocarboxylic acid metabolic process|
|anion transport|
|negative regulation of cell population proliferation|
|regulation of ion transport|
|ion homeostasis|
|response to lipid|
|carboxylic acid metabolic process|
|response to hormone|
|cellular lipid metabolic process|
|positive regulation of transport|
|response to organonitrogen compound|
|oxoacid metabolic process|
|response to drug|
|organic acid metabolic process|
|response to nitrogen compound|
|chemical homeostasis|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|lipid metabolic process|
|ion transport|
|response to endogenous stimulus|
|intracellular transport|
|response to oxygen-containing compound|
|extracellular space|
|regulation of cell population proliferation|
|homeostatic process|
|small molecule metabolic process|
|organic substance catabolic process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|cellular catabolic process|
|establishment of localization in cell|
|regulation of transport|
|positive regulation of cellular biosynthetic process|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13787
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.24 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='FABP3 Expression in NALM6 Cells: 0.24'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>