======= FADS2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: FADS2
  * **<color #00a2e8>Official Name</color>**: fatty acid desaturase 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9415|9415]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O95864|O95864]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=FADS2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20FADS2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606149|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Component of a lipid metabolic pathway that catalyzes biosynthesis of highly unsaturated fatty acids (HUFA) from precursor essential polyunsaturated fatty acids (PUFA) linoleic acid (LA) (18:2n-6) and alpha-linolenic acid (ALA) (18:3n-3). Catalyzes the first and rate limiting step in this pathway which is the desaturation of LA (18:2n-6) and ALA (18:3n-3) into gamma- linoleic acid (GLA) (18:3n-6) and stearidonic acid (18:4n-3) respectively and other desaturation steps. Highly unsaturated fatty acids (HUFA) play pivotal roles in many biological functions. It catalizes as well the introduction of a cis double bond in palmitate to produce the mono-unsaturated fatty acid sapienate, the most abundant fatty acid in sebum. {ECO:0000269|PubMed:12713571, ECO:0000269|PubMed:9867867}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Cyt-b5|
|FA desaturase|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|linoleoyl-CoA desaturase activity|
|stearoyl-CoA 9-desaturase activity|
|alpha-linolenic acid metabolic process|
|linoleic acid metabolic process|
|unsaturated fatty acid biosynthetic process|
|unsaturated fatty acid metabolic process|
|long-chain fatty acid metabolic process|
|fatty acid biosynthetic process|
|monocarboxylic acid biosynthetic process|
|carboxylic acid biosynthetic process|
|organic acid biosynthetic process|
|fatty acid metabolic process|
|drug metabolic process|
|monocarboxylic acid metabolic process|
|lipid biosynthetic process|
|small molecule biosynthetic process|
|carboxylic acid metabolic process|
|endoplasmic reticulum membrane|
|cellular lipid metabolic process|
|oxidation-reduction process|
|oxoacid metabolic process|
|organic acid metabolic process|
|lipid metabolic process|
|integral component of plasma membrane|
|small molecule metabolic process|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp417|Tubastatin-A 2.5μM R07 exp417]]|1.77|
|[[:results:exp497|Lead acetate 2000μM R08 exp497]]|1.78|
|[[:results:exp121|Golgicide-A 2μM R03 exp121]]|2.08|
|[[:results:exp78|Pterostilbene 16μM R02 exp78]]|2.65|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|3.09|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|3.25|
|[[:results:exp436|Dynasore 7μM R08 exp436]]|3.35|
|[[:results:exp180|Dynasore 10μM R04 exp180]]|4.08|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|5.01|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3122
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.29 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='FADS2 Expression in NALM6 Cells: 8.29'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>