======= FAF1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: FAF1
  * **<color #00a2e8>Official Name</color>**: Fas associated factor 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=11124|11124]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UNN5|Q9UNN5]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=FAF1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20FAF1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604460|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Potentiates but cannot initiate FAS-induced apoptosis.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|UBX|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|CD95 death-inducing signaling complex|
|cytoplasmic sequestering of NF-kappaB|
|VCP-NPL4-UFD1 AAA ATPase complex|
|protein kinase regulator activity|
|positive regulation of extrinsic apoptotic signaling pathway via death domain receptors|
|cytoplasmic sequestering of transcription factor|
|cytoplasmic sequestering of protein|
|NF-kappaB binding|
|positive regulation of DNA replication|
|positive regulation of extrinsic apoptotic signaling pathway|
|regulation of extrinsic apoptotic signaling pathway via death domain receptors|
|heat shock protein binding|
|ubiquitin binding|
|negative regulation of NF-kappaB transcription factor activity|
|maintenance of protein location|
|regulation of DNA replication|
|positive regulation of cellular protein catabolic process|
|regulation of extrinsic apoptotic signaling pathway|
|negative regulation of DNA-binding transcription factor activity|
|maintenance of location|
|positive regulation of apoptotic signaling pathway|
|nuclear envelope|
|positive regulation of protein catabolic process|
|protein domain specific binding|
|regulation of cellular protein catabolic process|
|positive regulation of protein complex assembly|
|ubiquitin protein ligase binding|
|proteasome-mediated ubiquitin-dependent protein catabolic process|
|proteasomal protein catabolic process|
|positive regulation of cellular catabolic process|
|regulation of protein catabolic process|
|regulation of apoptotic signaling pathway|
|regulation of DNA-binding transcription factor activity|
|positive regulation of catabolic process|
|regulation of protein complex assembly|
|protein kinase binding|
|positive regulation of cellular component biogenesis|
|ubiquitin-dependent protein catabolic process|
|modification-dependent protein catabolic process|
|modification-dependent macromolecule catabolic process|
|proteolysis involved in cellular protein catabolic process|
|cellular protein catabolic process|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|regulation of cell adhesion|
|protein catabolic process|
|perinuclear region of cytoplasm|
|positive regulation of cell death|
|regulation of protein kinase activity|
|regulation of cellular catabolic process|
|regulation of kinase activity|
|cellular macromolecule catabolic process|
|apoptotic process|
|regulation of cellular component biogenesis|
|regulation of transferase activity|
|regulation of catabolic process|
|macromolecule catabolic process|
|programmed cell death|
|organonitrogen compound catabolic process|
|cell death|
|negative regulation of molecular function|
|positive regulation of cellular component organization|
|proteolysis|
|regulation of protein phosphorylation|
|regulation of apoptotic process|
|regulation of programmed cell death|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|positive regulation of signal transduction|
|regulation of cell death|
|positive regulation of protein metabolic process|
|organic substance catabolic process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|cellular catabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of protein modification process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp359|FK-506 30μM R07 exp359]]|-1.75|
|[[:results:exp159|Docetaxel 0.001 to 0.002μM on day4 R04 exp159]]|1.7|
|[[:results:exp539|42°C R08 exp539]]|1.75|
|[[:results:exp18|Doxycycline 10μM R00 exp18]]|1.79|
|[[:results:exp14|Cycloheximide 0.02μM R00 exp14]]|1.82|
|[[:results:exp38|Wortmannin 5μM R00 exp38]]|1.83|
|[[:results:exp215|Colchicine 0.009μM R05 exp215]]|1.93|
|[[:results:exp30|Rapamycin 10μM R00 exp30]]|2.23|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.641|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3082
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.17 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='FAF1 Expression in NALM6 Cells: 6.17'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>