======= FAF2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: FAF2
  * **<color #00a2e8>Official Name</color>**: Fas associated factor family member 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=23197|23197]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96CS3|Q96CS3]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=FAF2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20FAF2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/616935|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Plays an important role in endoplasmic reticulum- associated degradation (ERAD) that mediates ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins (PubMed:18711132, PubMed:24215460). Involved in inhibition of lipid droplet degradation by binding to phospholipase PNPL2 and inhibiting its activity by promoting dissociation of PNPL2 from its endogenous activator, ABHD5 which inhibits the rate of triacylglycerol hydrolysis (PubMed:23297223). {ECO:0000269|PubMed:18711132, ECO:0000269|PubMed:23297223, ECO:0000269|PubMed:24215460}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|UBX|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|lipase inhibitor activity|
|lipase binding|
|VCP-NPL4-UFD1 AAA ATPase complex|
|retrograde protein transport, ER to cytosol|
|endoplasmic reticulum to cytosol transport|
|lipid droplet organization|
|protein exit from endoplasmic reticulum|
|ubiquitin-dependent ERAD pathway|
|ubiquitin binding|
|lipid droplet|
|ERAD pathway|
|azurophil granule lumen|
|response to unfolded protein|
|response to topologically incorrect protein|
|response to endoplasmic reticulum stress|
|ubiquitin protein ligase binding|
|proteasome-mediated ubiquitin-dependent protein catabolic process|
|proteasomal protein catabolic process|
|neutrophil degranulation|
|neutrophil activation involved in immune response|
|neutrophil mediated immunity|
|neutrophil activation|
|granulocyte activation|
|leukocyte degranulation|
|myeloid leukocyte mediated immunity|
|myeloid cell activation involved in immune response|
|ubiquitin-dependent protein catabolic process|
|modification-dependent protein catabolic process|
|modification-dependent macromolecule catabolic process|
|myeloid leukocyte activation|
|proteolysis involved in cellular protein catabolic process|
|cellular protein catabolic process|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|protein catabolic process|
|regulated exocytosis|
|leukocyte mediated immunity|
|negative regulation of catalytic activity|
|exocytosis|
|cellular macromolecule catabolic process|
|leukocyte activation|
|intracellular protein transport|
|response to organonitrogen compound|
|secretion by cell|
|endoplasmic reticulum|
|export from cell|
|macromolecule catabolic process|
|organonitrogen compound catabolic process|
|cell activation|
|response to nitrogen compound|
|immune effector process|
|secretion|
|negative regulation of molecular function|
|proteolysis|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|cellular response to stress|
|organic substance catabolic process|
|cellular catabolic process|
|establishment of localization in cell|
|nitrogen compound transport|
|immune response|
|extracellular region|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp462|Cadmium 60μM R08 exp462]]|-3.06|
|[[:results:exp107|UMK57 0.6μM R03 exp107]]|-2.74|
|[[:results:exp530|Thioridazine 5μM R08 exp530]]|-2.44|
|[[:results:exp421|VHL-ligand-1 20μM R07 exp421]]|-2.34|
|[[:results:exp438|NN-Diethyl-meta-toluamide 500μM R08 exp438]]|-2.32|
|[[:results:exp289|Hydroxyurea 15μM R06 exp289]]|-2.28|
|[[:results:exp457|Bisphenol F 50μM R08 exp457]]|-2.27|
|[[:results:exp29|Rapamycin 1μM R00 exp29]]|-2.24|
|[[:results:exp32|Rifampicin 10μM R00 exp32]]|-2.13|
|[[:results:exp486|Heregulin-B 44ng/ml R08 exp486]]|-2.08|
|[[:results:exp490|Hydroxychloroquine 30μM R08 exp490]]|-2.06|
|[[:results:exp73|LJH685 5μM R02 exp73]]|-2|
|[[:results:exp467|CAY10603 0.55μM R08 exp467]]|-1.98|
|[[:results:exp83|Trametinib 10μM R02 exp83]]|-1.9|
|[[:results:exp155|UNC1999 2μM R03 exp155]]|-1.9|
|[[:results:exp278|CVT-10216 0.1μM R06 exp278]]|-1.85|
|[[:results:exp333|All-trans-Retinoic-Acid 8μM R07 exp333]]|-1.82|
|[[:results:exp4|Actinomycin-D 0.01μM R00 exp4]]|-1.79|
|[[:results:exp513|ONC212 0.15μM R08 exp513]]|1.7|
|[[:results:exp126|GSK461364A 0.1μM R03 exp126]]|1.73|
|[[:results:exp532|TIC10 10μM R08 exp532]]|1.75|
|[[:results:exp143|Phenformin 20μM R03 exp143]]|1.76|
|[[:results:exp98|BI-6727 0.04μM R03 exp98]]|1.77|
|[[:results:exp349|Cytochalasin-B 5μM R07 exp349]]|1.78|
|[[:results:exp357|Dorsomorphin 5μM R07 exp357]]|1.78|
|[[:results:exp481|Ethambutol 25μM R08 exp481]]|1.79|
|[[:results:exp275|Citral 75μM R06 exp275]]|1.8|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|1.83|
|[[:results:exp70|INK128 0.2μM R02 exp70]]|1.84|
|[[:results:exp241|QNZ 0.01μM R05 exp241]]|1.85|
|[[:results:exp330|5-Azacytidine 2μM R07 exp330]]|1.86|
|[[:results:exp198|Etoposide 0.1μM R05 exp198]]|1.87|
|[[:results:exp539|42°C R08 exp539]]|1.93|
|[[:results:exp22|MLN-4924 2μM R00 exp22]]|1.96|
|[[:results:exp431|Rotenone 0.07μM R08 exp431]]|1.96|
|[[:results:exp401|SNS-032 25μM R07 exp401]]|1.97|
|[[:results:exp535|Trimetrexate 0.03μM R08 exp535]]|1.97|
|[[:results:exp518|RK-33 8μM R08 exp518]]|1.98|
|[[:results:exp414|Tozasertib 0.1μM R07 exp414]]|1.98|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|1.99|
|[[:results:exp502|Milciclib 2μM R08 exp502]]|2|
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|2.14|
|[[:results:exp134|MS023 2μM R03 exp134]]|2.16|
|[[:results:exp93|DABN racemic mixture R03 exp93]]|2.17|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|2.17|
|[[:results:exp24|Nocodazole 0.2μM R00 exp24]]|2.24|
|[[:results:exp294|Nutlin-3A 1.6μM R06 exp294]]|2.25|
|[[:results:exp85|UM0129480 7μM R02 exp85]]|2.29|
|[[:results:exp505|ML-792 0.2μM R08 exp505]]|2.3|
|[[:results:exp531|THZ1 0.06μM R08 exp531]]|2.37|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|2.38|
|[[:results:exp48|Mubritinib 0.2μM R01 exp48]]|2.39|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|2.41|
|[[:results:exp80|RO-3307 4.7μM R02 exp80]]|2.42|
|[[:results:exp248|UM0131023 0.05μM R05 exp248]]|2.45|
|[[:results:exp363|GSK-J4 1-1.25μM to day4 R07 exp363]]|2.52|
|[[:results:exp527|Tanespimycin 14μM R08 exp527]]|2.63|
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|2.66|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|2.7|
|[[:results:exp355|Dinaciclib 0.007μM R07 exp355]]|2.71|
|[[:results:exp439|QNZ 0.01μM R08 exp439]]|2.72|
|[[:results:exp343|Centrinone 0.5μM R07 exp343]]|2.87|
|[[:results:exp214|2-Deoxy-D-glucose 800μM R05 exp214]]|2.91|
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|3.08|
|[[:results:exp444|THZ531 0.225μM R08 exp444]]|3.11|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|3.22|
|[[:results:exp211|AICAR 240μM R05 exp211]]|3.32|
|[[:results:exp503|Mitomycin-C 0.06μM R08 exp503]]|3.46|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|3.48|
|[[:results:exp259|6-Thio-2-deoxyguanosine 2μM R06 exp259]]|3.53|
|[[:results:exp443|SNS-032 15μM R08 exp443]]|3.6|
|[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|3.71|
|[[:results:exp459|Bleomycin 5μM R08 exp459]]|3.81|
|[[:results:exp116|AICAR 240μM R03 exp116]]|3.86|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|3.87|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|3.95|
|[[:results:exp524|Staurosporine 0.02μM R08 exp524]]|3.99|
|[[:results:exp199|Etoposide 0.3μM R05 exp199]]|4.07|
|[[:results:exp19|Etoposide 1μM R00 exp19]]|4.13|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|4.95|
|[[:results:exp282|Fluvastatin 2.2μM R06 exp282]]|4.98|
|[[:results:exp135|MS023 7μM R03 exp135]]|5.1|
|[[:results:exp456|Benzoate 20000μM R08 exp456]]|5.36|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:plaa|PLAA]]|0.693|
|[[:human genes:b:bak1|BAK1]]|0.691|
|[[:human genes:u:ubqln1|UBQLN1]]|0.676|
|[[:human genes:u:ube2g2|UBE2G2]]|0.671|
|[[:human genes:a:apaf1|APAF1]]|0.653|
|[[:human genes:v:vdac2|VDAC2]]|0.65|
|[[:human genes:d:dohh|DOHH]]|0.633|
|[[:human genes:c:cycs|CYCS]]|0.595|
|[[:human genes:r:rptor|RPTOR]]|0.592|
|[[:human genes:m:march5|MARCH5]]|0.592|
|[[:human genes:c:casp9|CASP9]]|0.591|
|[[:human genes:s:serf2|SERF2]]|0.589|
|[[:human genes:h:hars|HARS]]|0.565|
|[[:human genes:h:hspd1|HSPD1]]|0.558|
|[[:human genes:k:kdsr|KDSR]]|0.558|
|[[:human genes:d:diablo|DIABLO]]|0.549|
|[[:human genes:t:thg1l|THG1L]]|0.546|
|[[:human genes:m:mtor|MTOR]]|0.535|
|[[:human genes:e:eny2|ENY2]]|0.526|
|[[:human genes:g:gabpa|GABPA]]|0.516|
|[[:human genes:g:gfpt1|GFPT1]]|0.513|
|[[:human genes:r:rnmt|RNMT]]|0.511|
|[[:human genes:a:atp5j|ATP5J]]|0.507|
|[[:human genes:t:trim28|TRIM28]]|0.506|
|[[:human genes:r:romo1|ROMO1]]|0.504|
|[[:human genes:h:hccs|HCCS]]|0.503|
|[[:human genes:b:bap1|BAP1]]|0.501|
|[[:human genes:a:atad1|ATAD1]]|0.501|
|[[:human genes:b:bptf|BPTF]]|0.5|
|[[:human genes:w:wdr24|WDR24]]|0.498|
|[[:human genes:n:nsd1|NSD1]]|0.498|
|[[:human genes:u:uap1|UAP1]]|0.494|
|[[:human genes:v:vhl|VHL]]|0.492|
|[[:human genes:z:zzz3|ZZZ3]]|0.49|
|[[:human genes:a:aup1|AUP1]]|0.484|
|[[:human genes:g:gmppb|GMPPB]]|0.48|
|[[:human genes:m:metap2|METAP2]]|0.475|
|[[:human genes:e:eif4e|EIF4E]]|0.474|
|[[:human genes:t:triap1|TRIAP1]]|0.474|
|[[:human genes:a:atp5i|ATP5I]]|0.471|
|[[:human genes:p:ppp2r3c|PPP2R3C]]|0.468|
|[[:human genes:m:mfn1|MFN1]]|0.464|
|[[:human genes:t:tada2a|TADA2A]]|0.463|
|[[:human genes:s:srp14|SRP14]]|0.46|
|[[:human genes:d:dhps|DHPS]]|0.458|
|[[:human genes:s:suv420h1|SUV420H1]]|0.456|
|[[:human genes:n:nae1|NAE1]]|0.454|
|[[:human genes:i:id3|ID3]]|0.454|
|[[:human genes:a:alg1|ALG1]]|0.448|
|[[:human genes:m:meaf6|MEAF6]]|0.442|
|[[:human genes:m:mlst8|MLST8]]|0.441|
|[[:human genes:a:atp5a1|ATP5A1]]|0.44|
|[[:human genes:a:atp5o|ATP5O]]|0.437|
|[[:human genes:u:ube2k|UBE2K]]|0.436|
|[[:human genes:s:stau1|STAU1]]|0.436|
|[[:human genes:r:rad23b|RAD23B]]|0.435|
|[[:human genes:p:ppa2|PPA2]]|0.435|
|[[:human genes:w:wdr59|WDR59]]|0.435|
|[[:human genes:r:rtcb|RTCB]]|0.434|
|[[:human genes:d:dpagt1|DPAGT1]]|0.433|
|[[:human genes:p:pmm2|PMM2]]|0.432|
|[[:human genes:c:ctdnep1|CTDNEP1]]|0.431|
|[[:human genes:u:ube2j1|UBE2J1]]|0.431|
|[[:human genes:c:cept1|CEPT1]]|0.431|
|[[:human genes:l:lamtor5|LAMTOR5]]|0.431|
|[[:human genes:o:opa1|OPA1]]|0.43|
|[[:human genes:u:utp23|UTP23]]|0.428|
|[[:human genes:p:pelo|PELO]]|0.428|
|[[:human genes:e:exoc4|EXOC4]]|0.428|
|[[:human genes:s:srrd|SRRD]]|0.425|
|[[:human genes:d:ddx42|DDX42]]|0.423|
|[[:human genes:s:seh1l|SEH1L]]|0.421|
|[[:human genes:p:pdpk1|PDPK1]]|0.417|
|[[:human genes:d:ddhd2|DDHD2]]|0.416|
|[[:human genes:p:ppp6c|PPP6C]]|0.415|
|[[:human genes:t:taf4|TAF4]]|0.412|
|[[:human genes:a:atp5b|ATP5B]]|0.412|
|[[:human genes:u:ube2m|UBE2M]]|0.411|
|[[:human genes:d:dhrsx|DHRSX]]|0.409|
|[[:human genes:d:dad1|DAD1]]|0.409|
|[[:human genes:k:kctd5|KCTD5]]|0.407|
|[[:human genes:b:brwd1|BRWD1]]|0.406|
|[[:human genes:p:pik3r4|PIK3R4]]|0.405|
|[[:human genes:d:dnajc3|DNAJC3]]|0.404|
|[[:human genes:e:exoc3|EXOC3]]|0.404|
|[[:human genes:e:elp3|ELP3]]|0.403|
|[[:human genes:c:cul3|CUL3]]|0.403|
|[[:human genes:t:taz|TAZ]]|0.4|
|[[:human genes:a:alg5|ALG5]]|0.4|
|[[:human genes:t:timm13|TIMM13]]|0.4|
|[[:human genes:c:cbfb|CBFB]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 128/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|5/28|
|blood|4/28|
|bone|2/26|
|breast|2/33|
|central nervous system|11/56|
|cervix|0/4|
|colorectal|2/17|
|esophagus|5/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|10/21|
|liver|6/20|
|lung|12/75|
|lymphocyte|4/16|
|ovary|6/26|
|pancreas|5/24|
|peripheral nervous system|0/16|
|plasma cell|11/15|
|prostate|0/1|
|skin|1/24|
|soft tissue|1/9|
|thyroid|1/2|
|upper aerodigestive|0/22|
|urinary tract|5/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2654
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.07 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='FAF2 Expression in NALM6 Cells: 7.07'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>