======= FAIM2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: FAIM2
  * **<color #00a2e8>Official Name</color>**: Fas apoptotic inhibitory molecule 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=23017|23017]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9BWQ8|Q9BWQ8]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=FAIM2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20FAIM2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604306|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Antiapoptotic protein which protects cells uniquely from Fas-induced apoptosis. Regulates Fas-mediated apoptosis in neurons by interfering with caspase-8 activation. May play a role in cerebellar development by affecting cerebellar size, internal granular layer (IGL) thickness, and Purkinje cell (PC) development. {ECO:0000269|PubMed:10535980, ECO:0000269|PubMed:17635665}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Bax1-I|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cerebellar Purkinje cell differentiation|
|cerebellar Purkinje cell layer formation|
|cerebellar granular layer development|
|cerebellar Purkinje cell layer morphogenesis|
|cell differentiation in hindbrain|
|cerebellar cortex formation|
|cerebellar Purkinje cell layer development|
|cerebellar cortex morphogenesis|
|cerebellum morphogenesis|
|negative regulation of extrinsic apoptotic signaling pathway via death domain receptors|
|hindbrain morphogenesis|
|cerebellar cortex development|
|response to ischemia|
|regulation of extrinsic apoptotic signaling pathway via death domain receptors|
|negative regulation of extrinsic apoptotic signaling pathway|
|cerebellum development|
|metencephalon development|
|negative regulation of neuron apoptotic process|
|hindbrain development|
|regulation of extrinsic apoptotic signaling pathway|
|central nervous system neuron differentiation|
|postsynaptic membrane|
|regulation of neuron apoptotic process|
|negative regulation of neuron death|
|membrane raft|
|negative regulation of apoptotic signaling pathway|
|regulation of neuron death|
|regulation of apoptotic signaling pathway|
|cell junction|
|brain development|
|head development|
|negative regulation of apoptotic process|
|anatomical structure formation involved in morphogenesis|
|negative regulation of programmed cell death|
|apoptotic process|
|central nervous system development|
|Golgi apparatus|
|negative regulation of cell death|
|neuron differentiation|
|endoplasmic reticulum|
|programmed cell death|
|cell death|
|negative regulation of signal transduction|
|negative regulation of cell communication|
|negative regulation of signaling|
|generation of neurons|
|regulation of apoptotic process|
|regulation of programmed cell death|
|negative regulation of response to stimulus|
|neurogenesis|
|regulation of cell death|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp120|Dimethyl-Sulfoxide 1pc R03 exp120]]|-1.93|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|-1.78|
|[[:results:exp231|Epothilone-B 0.0015μM R05 exp231]]|-1.71|
|[[:results:exp392|PT-1 25μM R07 exp392]]|1.9|
|[[:results:exp419|Tunicamycin 0.04 to 0.075μM  on day4 R07 exp419]]|1.97|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9359
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -2.47 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='FAIM2 Expression in NALM6 Cells: -2.47'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>