======= FAM179B =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TOGARAM1
  * **<color #00a2e8>Official Name</color>**: TOG array regulator of axonemal microtubules 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=23116|23116]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y4F4|Q9Y4F4]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=FAM179B&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20FAM179B|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/617618|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Required for normal structure and function of primary cilia. Plays a role in the organization of axoneme microtubule bundles in primary cilia (By similarity). Interacts with microtubules and promotes microtubule polymerization via its HEAT repeat domains, especially those in TOG region 2 and 4 (By similarity). {ECO:0000250|UniProtKB:Q17423, ECO:0000250|UniProtKB:Q6A070}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|CLASP N|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of microtubule polymerization|
|positive regulation of microtubule polymerization or depolymerization|
|non-motile cilium assembly|
|regulation of microtubule polymerization|
|axoneme assembly|
|regulation of microtubule polymerization or depolymerization|
|microtubule bundle formation|
|positive regulation of protein polymerization|
|ciliary basal body|
|regulation of microtubule cytoskeleton organization|
|positive regulation of supramolecular fiber organization|
|cilium|
|positive regulation of cytoskeleton organization|
|regulation of microtubule-based process|
|regulation of protein polymerization|
|positive regulation of protein complex assembly|
|microtubule|
|cilium assembly|
|regulation of supramolecular fiber organization|
|cilium organization|
|plasma membrane bounded cell projection assembly|
|regulation of protein complex assembly|
|cell projection assembly|
|microtubule cytoskeleton organization|
|positive regulation of cellular component biogenesis|
|regulation of cytoskeleton organization|
|positive regulation of organelle organization|
|microtubule-based process|
|organelle assembly|
|regulation of cellular component biogenesis|
|cytoskeleton organization|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|positive regulation of cellular component organization|
|regulation of organelle organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp256|HMS-I1 10μM R06 exp256]]|-2.1|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|-1.88|
|[[:results:exp37|Wortmannin 0.5μM R00 exp37]]|-1.75|
|[[:results:exp82|Torin1 0.08μM R02 exp82]]|1.71|
|[[:results:exp285|GW501516 25μM R06 exp285]]|1.72|
|[[:results:exp376|Losmapimod 1μM R07 exp376]]|1.73|
|[[:results:exp513|ONC212 0.15μM R08 exp513]]|1.75|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|1.77|
|[[:results:exp345|Cidofovir 10μM R07 exp345]]|1.78|
|[[:results:exp418|Tunicamycin 0.04μM R07 exp418]]|1.82|
|[[:results:exp389|PF-06409577 20μM R07 exp389]]|1.91|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rrm1|RRM1]]|0.435|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8239
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.06 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='FAM179B Expression in NALM6 Cells: 4.06'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>