======= FAM83D =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: FAM83D
  * **<color #00a2e8>Official Name</color>**: family with sequence similarity 83 member D
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=81610|81610]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9H4H8|Q9H4H8]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=FAM83D&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20FAM83D|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/618380|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Probable proto-oncogene that regulates cell proliferation, growth, migration and epithelial to mesenchymal transition. Through the degradation of FBXW7, may act indirectly on the expression and downstream signaling of MTOR, JUN and MYC (PubMed:24344117). May play also a role in cell proliferation through activation of the ERK1/ERK2 signaling cascade (PubMed:25646692). May also be important for proper chromosome congression and alignment during mitosis through its interaction with KIF22. {ECO:0000269|PubMed:18485706, ECO:0000269|PubMed:24344117, ECO:0000269|PubMed:25646692}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DUF1669|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|protein localization to mitotic spindle|
|mitotic spindle pole|
|protein localization to microtubule cytoskeleton|
|protein localization to cytoskeleton|
|kinesin binding|
|positive regulation of cell cycle G1/S phase transition|
|metaphase plate congression|
|epithelial to mesenchymal transition|
|establishment of chromosome localization|
|chromosome localization|
|positive regulation of cell cycle phase transition|
|regulation of TOR signaling|
|mesenchymal cell differentiation|
|regulation of cell cycle G1/S phase transition|
|nuclear chromosome segregation|
|mesenchyme development|
|microtubule binding|
|chromosome segregation|
|positive regulation of cell cycle process|
|regulation of ERK1 and ERK2 cascade|
|establishment of organelle localization|
|positive regulation of cell cycle|
|regulation of protein catabolic process|
|regulation of cell cycle phase transition|
|protein kinase binding|
|cell division|
|cell population proliferation|
|organelle localization|
|protein localization to organelle|
|regulation of MAPK cascade|
|regulation of cell cycle process|
|cell migration|
|regulation of catabolic process|
|cell cycle process|
|localization of cell|
|cell motility|
|regulation of cell cycle|
|locomotion|
|cell cycle|
|regulation of protein phosphorylation|
|movement of cell or subcellular component|
|cellular protein localization|
|regulation of phosphorylation|
|cellular macromolecule localization|
|tissue development|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of intracellular signal transduction|
|establishment of localization in cell|
|regulation of protein modification process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|-1.8|
|[[:results:exp503|Mitomycin-C 0.06μM R08 exp503]]|-1.75|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.439|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 14287
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.4 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='FAM83D Expression in NALM6 Cells: 5.4'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>