======= FANCM =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: FANCM
  * **<color #00a2e8>Official Name</color>**: FA complementation group M
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=57697|57697]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8IYD8|Q8IYD8]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=FANCM&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20FANCM|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/609644|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group M. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]. 
  * **<color #00a2e8>UniProt Summary</color>**:  DNA-dependent ATPase component of the Fanconi anemia (FA) core complex (PubMed:16116422). Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage (PubMed:16116422, PubMed:19423727, PubMed:20347428, PubMed:20347429). In complex with CENPS and CENPX, binds double-stranded DNA (dsDNA), fork-structured DNA (fsDNA) and Holliday junction substrates (PubMed:20347428, PubMed:20347429). Its ATP-dependent DNA branch migration activity can process branched DNA structures such as a movable replication fork. This activity is strongly stimulated in the presence of CENPS and CENPX (PubMed:20347429). In complex with FAAP24, efficiently binds to single-strand DNA (ssDNA), splayed-arm DNA, and 3'-flap substrates (PubMed:17289582). In vitro, on its own, strongly binds ssDNA oligomers and weakly fsDNA, but does not bind to dsDNA (PubMed:16116434). {ECO:0000269|PubMed:16116422, ECO:0000269|PubMed:16116434, ECO:0000269|PubMed:17289582, ECO:0000269|PubMed:19423727, ECO:0000269|PubMed:20347428, ECO:0000269|PubMed:20347429}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Helicase C|
|ResIII|
|DEAD|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|FANCM-MHF complex|
|positive regulation of protein monoubiquitination|
|regulation of protein monoubiquitination|
|nuclease activity|
|Fanconi anaemia nuclear complex|
|resolution of meiotic recombination intermediates|
|meiotic chromosome separation|
|chromosome separation|
|replication fork processing|
|DNA-dependent DNA replication maintenance of fidelity|
|reciprocal meiotic recombination|
|homologous recombination|
|interstrand cross-link repair|
|RNA helicase activity|
|meiotic chromosome segregation|
|meiosis I|
|meiosis I cell cycle process|
|positive regulation of protein ubiquitination|
|DNA-dependent DNA replication|
|positive regulation of protein modification by small protein conjugation or removal|
|meiotic nuclear division|
|meiotic cell cycle process|
|regulation of protein ubiquitination|
|DNA replication|
|nuclear chromosome segregation|
|DNA recombination|
|meiotic cell cycle|
|regulation of protein modification by small protein conjugation or removal|
|chromosome segregation|
|nuclear division|
|nucleic acid phosphodiester bond hydrolysis|
|organelle fission|
|chromatin binding|
|DNA repair|
|DNA metabolic process|
|cellular response to DNA damage stimulus|
|cell cycle process|
|positive regulation of protein modification process|
|cell cycle|
|reproductive process|
|reproduction|
|DNA binding|
|ATP binding|
|positive regulation of cellular protein metabolic process|
|cellular response to stress|
|positive regulation of protein metabolic process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|regulation of protein modification process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp512|Olaparib 4μM R08 exp512]]|-2.25|
|[[:results:exp520|Rucaparib 6.5μM R08 exp520]]|-1.81|
|[[:results:exp215|Colchicine 0.009μM R05 exp215]]|1.76|
|[[:results:exp31|Rifampicin 1μM R00 exp31]]|1.8|
|[[:results:exp406|Thalidomide 20μM R07 exp406]]|2.37|
|[[:results:exp294|Nutlin-3A 1.6μM R06 exp294]]|5.25|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:s:stra13|STRA13]]|0.507|
|[[:human genes:d:dido1|DIDO1]]|0.457|
|[[:human genes:p:psmb4|PSMB4]]|0.457|
|[[:human genes:c:cdc73|CDC73]]|0.444|
|[[:human genes:f:fancf|FANCF]]|0.437|
|[[:human genes:p:polr2j3|POLR2J3]]|0.429|
|[[:human genes:t:ticrr|TICRR]]|0.418|
|[[:human genes:c:chaf1a|CHAF1A]]|0.417|
|[[:human genes:r:rad21|RAD21]]|0.416|
|[[:human genes:a:aqr|AQR]]|0.414|
|[[:human genes:i:iscu|ISCU]]|0.413|
|[[:human genes:s:sf3a1|SF3A1]]|0.413|
|[[:human genes:m:mt1e|MT1E]]|0.408|
|[[:human genes:p:psap|PSAP]]|0.408|
|[[:human genes:t:tfrc|TFRC]]|0.404|
|[[:human genes:a:apitd1|APITD1]]|0.403|
|[[:human genes:c:cope|COPE]]|0.403|
|[[:human genes:e:elmod3|ELMOD3]]|0.402|
|[[:human genes:r:rbm39|RBM39]]|0.401|
|[[:human genes:f:fdx1l|FDX1L]]|0.4|
|[[:human genes:a:aaas|AAAS]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 14/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|4/26|
|breast|0/33|
|central nervous system|1/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|1/1|
|gastric|1/16|
|kidney|1/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|2/26|
|pancreas|0/24|
|peripheral nervous system|2/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1086
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.79 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='FANCM Expression in NALM6 Cells: 5.79'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>