======= FAP =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: FAP
  * **<color #00a2e8>Official Name</color>**: fibroblast activation protein alpha
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2191|2191]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q12884|Q12884]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=FAP&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20FAP|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600403|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a homodimeric integral membrane gelatinase belonging to the serine protease family. It is selectively expressed in reactive stromal fibroblasts of epithelial cancers, granulation tissue of healing wounds, and malignant cells of bone and soft tissue sarcomas. This protein is thought to be involved in the control of fibroblast growth or epithelial-mesenchymal interactions during development, tissue repair, and epithelial carcinogenesis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2014]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Cell surface glycoprotein serine protease that participates in extracellular matrix degradation and involved in many cellular processes including tissue remodeling, fibrosis, wound healing, inflammation and tumor growth. Both plasma membrane and soluble forms exhibit post-proline cleaving endopeptidase activity, with a marked preference for Ala/Ser-Gly-Pro-Ser/Asn/Ala consensus sequences, on substrate such as alpha-2-antiplasmin SERPINF2 and SPRY2 (PubMed:14751930, PubMed:16223769, PubMed:16480718, PubMed:16410248, PubMed:17381073, PubMed:18095711, PubMed:21288888, PubMed:24371721). Degrade also gelatin, heat-denatured type I collagen, but not native collagen type I and IV, vibronectin, tenascin, laminin, fibronectin, fibrin or casein (PubMed:9065413, PubMed:2172980, PubMed:7923219, PubMed:10347120, PubMed:10455171, PubMed:12376466, PubMed:16223769, PubMed:16651416, PubMed:18095711). Have also dipeptidyl peptidase activity, exhibiting the ability to hydrolyze the prolyl bond two residues from the N-terminus of synthetic dipeptide substrates provided that the penultimate residue is proline, with a preference for Ala-Pro, Ile-Pro, Gly-Pro, Arg-Pro and Pro-Pro (PubMed:10347120, PubMed:10593948, PubMed:16175601, PubMed:16223769, PubMed:16651416, PubMed:16410248, PubMed:17381073, PubMed:21314817, PubMed:24371721, PubMed:24717288). Natural neuropeptide hormones for dipeptidyl peptidase are the neuropeptide Y (NPY), peptide YY (PYY), substance P (TAC1) and brain natriuretic peptide 32 (NPPB) (PubMed:21314817). The plasma membrane form, in association with either DPP4, PLAUR or integrins, is involved in the pericellular proteolysis of the extracellular matrix (ECM), and hence promotes cell adhesion, migration and invasion through the ECM. Plays a role in tissue remodeling during development and wound healing. Participates in the cell invasiveness towards the ECM in malignant melanoma cancers. Enhances tumor growth progression by increasing angiogenesis, collagen fiber degradation and apoptosis and by reducing antitumor response of the immune system. Promotes glioma cell invasion through the brain parenchyma by degrading the proteoglycan brevican. Acts as a tumor suppressor in melanocytic cells through regulation of cell proliferation and survival in a serine protease activity-independent manner. {ECO:0000250|UniProtKB:P97321, ECO:0000269|PubMed:10347120, ECO:0000269|PubMed:10455171, ECO:0000269|PubMed:10593948, ECO:0000269|PubMed:12376466, ECO:0000269|PubMed:14751930, ECO:0000269|PubMed:16175601, ECO:0000269|PubMed:16223769, ECO:0000269|PubMed:16410248, ECO:0000269|PubMed:16480718, ECO:0000269|PubMed:16651416, ECO:0000269|PubMed:17105646, ECO:0000269|PubMed:17381073, ECO:0000269|PubMed:18095711, ECO:0000269|PubMed:20707604, ECO:0000269|PubMed:21288888, ECO:0000269|PubMed:21314817, ECO:0000269|PubMed:2172980, ECO:0000269|PubMed:24371721, ECO:0000269|PubMed:24717288, ECO:0000269|PubMed:7923219, ECO:0000269|PubMed:9065413}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DPPIV N|
|Abhydrolase 5|
|Abhydrolase 6|
|Peptidase S9|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|melanocyte apoptotic process|
|melanocyte proliferation|
|negative regulation of extracellular matrix disassembly|
|negative regulation of cell proliferation involved in contact inhibition|
|regulation of collagen catabolic process|
|invadopodium membrane|
|contact inhibition|
|negative regulation of extracellular matrix organization|
|regulation of fibrinolysis|
|basal part of cell|
|positive regulation of execution phase of apoptosis|
|dipeptidyl-peptidase activity|
|regulation of extracellular matrix disassembly|
|mitotic cell cycle arrest|
|lamellipodium membrane|
|regulation of extracellular matrix organization|
|regulation of collagen metabolic process|
|regulation of execution phase of apoptosis|
|serine-type peptidase activity|
|endothelial cell migration|
|apical part of cell|
|endopeptidase activity|
|regulation of blood coagulation|
|regulation of hemostasis|
|positive regulation of cell cycle arrest|
|peptidase activity|
|regulation of coagulation|
|epithelial cell migration|
|epithelial cell proliferation|
|epithelium migration|
|tissue migration|
|ruffle membrane|
|protease binding|
|metalloendopeptidase activity|
|regulation of cell cycle arrest|
|integrin binding|
|regulation of wound healing|
|cell cycle arrest|
|protein dimerization activity|
|serine-type endopeptidase activity|
|regulation of response to wounding|
|ameboidal-type cell migration|
|lamellipodium|
|positive regulation of cell cycle process|
|negative regulation of mitotic cell cycle|
|angiogenesis|
|positive regulation of cell cycle|
|blood vessel morphogenesis|
|focal adhesion|
|blood vessel development|
|regulation of body fluid levels|
|vasculature development|
|cardiovascular system development|
|cell population proliferation|
|negative regulation of cell cycle|
|proteolysis involved in cellular protein catabolic process|
|cell surface|
|cellular protein catabolic process|
|regulation of mitotic cell cycle|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|tube morphogenesis|
|negative regulation of cell population proliferation|
|protein catabolic process|
|positive regulation of cell death|
|negative regulation of cellular component organization|
|regulation of cell cycle process|
|tube development|
|circulatory system development|
|protein homodimerization activity|
|anatomical structure formation involved in morphogenesis|
|cellular macromolecule catabolic process|
|apoptotic process|
|cell adhesion|
|biological adhesion|
|cell migration|
|regulation of catabolic process|
|cell cycle process|
|macromolecule catabolic process|
|programmed cell death|
|organonitrogen compound catabolic process|
|localization of cell|
|cell motility|
|cell death|
|regulation of response to external stimulus|
|regulation of cell cycle|
|proteolysis|
|locomotion|
|cell cycle|
|regulation of response to stress|
|regulation of apoptotic process|
|movement of cell or subcellular component|
|regulation of programmed cell death|
|extracellular space|
|regulation of cell population proliferation|
|regulation of cell death|
|organic substance catabolic process|
|cellular catabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|1.93|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 18374
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -3.59 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='FAP Expression in NALM6 Cells: -3.59'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>