======= FAR1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: FAR1
  * **<color #00a2e8>Official Name</color>**: fatty acyl-CoA reductase 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=84188|84188]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8WVX9|Q8WVX9]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=FAR1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20FAR1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/616107|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is required for the reduction of fatty acids to fatty alcohols, a process that is required for the synthesis of monoesters and ether lipids. NADPH is required as a cofactor in this reaction, and 16-18 carbon saturated and unsaturated fatty acids are the preferred substrate. This is a peroxisomal membrane protein, and studies suggest that the N-terminus contains a large catalytic domain located on the outside of the peroxisome, while the C-terminus is exposed to the matrix of the peroxisome. Studies indicate that the regulation of this protein is dependent on plasmalogen levels. Mutations in this gene have been associated with individuals affected by severe intellectual disability, early-onset epilepsy, microcephaly, congenital cataracts, growth retardation, and spasticity (PMID: 25439727). A pseudogene of this gene is located on chromosome 13. [provided by RefSeq, Jan 2015]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Catalyzes the reduction of saturated and unsaturated C16 or C18 fatty acyl-CoA to fatty alcohols (PubMed:15220348, PubMed:24108123). It plays an essential role in the production of ether lipids/plasmalogens which synthesis requires fatty alcohols (PubMed:20071337, PubMed:24108123). In parallel, it is also required for wax monoesters production since fatty alcohols also constitute a substrate for their synthesis (By similarity). {ECO:0000250|UniProtKB:Q922J9, ECO:0000269|PubMed:15220348, ECO:0000269|PubMed:20071337, ECO:0000269|PubMed:24108123}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Epimerase|
|Sterile|
|NAD binding 4|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|fatty-acyl-CoA reductase (alcohol-forming) activity|
|alcohol-forming fatty acyl-CoA reductase activity|
|wax metabolic process|
|wax biosynthetic process|
|ether lipid biosynthetic process|
|ether biosynthetic process|
|glycerol ether biosynthetic process|
|cellular lipid biosynthetic process|
|ether lipid metabolic process|
|glycerol ether metabolic process|
|integral component of peroxisomal membrane|
|ether metabolic process|
|long-chain fatty-acyl-CoA metabolic process|
|fatty-acyl-CoA metabolic process|
|peroxisomal matrix|
|peroxisomal membrane|
|fatty acid derivative biosynthetic process|
|acyl-CoA metabolic process|
|thioester metabolic process|
|peroxisome|
|oxidoreductase activity|
|purine nucleoside bisphosphate metabolic process|
|nucleoside bisphosphate metabolic process|
|ribonucleoside bisphosphate metabolic process|
|fatty acid derivative metabolic process|
|glycerophospholipid biosynthetic process|
|glycerolipid biosynthetic process|
|phospholipid biosynthetic process|
|coenzyme metabolic process|
|glycerophospholipid metabolic process|
|purine ribonucleotide metabolic process|
|ribonucleotide metabolic process|
|purine nucleotide metabolic process|
|ribose phosphate metabolic process|
|sulfur compound metabolic process|
|purine-containing compound metabolic process|
|phospholipid metabolic process|
|glycerolipid metabolic process|
|cofactor metabolic process|
|nucleotide metabolic process|
|nucleoside phosphate metabolic process|
|organophosphate biosynthetic process|
|nucleobase-containing small molecule metabolic process|
|lipid biosynthetic process|
|cellular amide metabolic process|
|organophosphate metabolic process|
|cellular lipid metabolic process|
|oxidation-reduction process|
|carbohydrate derivative metabolic process|
|lipid metabolic process|
|small molecule metabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp412|THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412]]|-2.78|
|[[:results:exp347|Cyclosporin-A 0.8μM R07 exp347]]|-2.27|
|[[:results:exp407|Thapsigargin 0.005μM R07 exp407]]|-1.99|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|-1.96|
|[[:results:exp32|Rifampicin 10μM R00 exp32]]|-1.91|
|[[:results:exp23|Nocodazole 0.02μM R00 exp23]]|-1.88|
|[[:results:exp413|THZ531 0.11 to 0.175μM on day4 R07 exp413]]|-1.81|
|[[:results:exp422|Wiskostatin 3μM R07 exp422]]|-1.77|
|[[:results:exp278|CVT-10216 0.1μM R06 exp278]]|-1.75|
|[[:results:exp444|THZ531 0.225μM R08 exp444]]|-1.75|
|[[:results:exp410|THZ531 0.11 to 0.125μM on day4 R07 exp410]]|-1.72|
|[[:results:exp321|ABT-702 5μM plus Deferoxamine 11μM R07 exp321]]|1.73|
|[[:results:exp536|Vitamin-D3 40μM R08 exp536]]|1.73|
|[[:results:exp285|GW501516 25μM R06 exp285]]|1.74|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|1.86|
|[[:results:exp431|Rotenone 0.07μM R08 exp431]]|1.94|
|[[:results:exp228|Demecolcine 0.03μM R05 exp228]]|2.16|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:a:agps|AGPS]]|0.457|
|[[:human genes:t:tmem189|TMEM189]]|0.44|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11747
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.89 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='FAR1 Expression in NALM6 Cells: 6.89'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>