======= FASTKD2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: FASTKD2
  * **<color #00a2e8>Official Name</color>**: FAST kinase domains 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=22868|22868]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NYY8|Q9NYY8]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=FASTKD2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20FASTKD2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/612322|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a protein that is localized in the mitochondrial inner compartment and that may play a role in mitochondrial apoptosis. Nonsense mutations have been reported to result in cytochrome c oxidase deficiency. [provided by RefSeq, Oct 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Plays an important role in assembly of the mitochondrial large ribosomal subunit (PubMed:25683715). {ECO:0000269|PubMed:25683715}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|FAST 1|
|RAP|
|FAST 2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|mitochondrial large ribosomal subunit assembly|
|mitochondrial ribosome assembly|
|ribonucleoprotein granule|
|positive regulation of mitochondrial translation|
|regulation of mitochondrial translation|
|regulation of mitochondrial gene expression|
|ribosomal large subunit assembly|
|rRNA binding|
|mitochondrial nucleoid|
|intercellular bridge|
|ribosome assembly|
|ribosomal large subunit biogenesis|
|positive regulation of translation|
|positive regulation of cellular amide metabolic process|
|cellular respiration|
|ribonucleoprotein complex assembly|
|energy derivation by oxidation of organic compounds|
|protein kinase activity|
|ribonucleoprotein complex subunit organization|
|ribosome biogenesis|
|regulation of translation|
|regulation of cellular amide metabolic process|
|generation of precursor metabolites and energy|
|ribonucleoprotein complex biogenesis|
|posttranscriptional regulation of gene expression|
|organelle assembly|
|cellular protein-containing complex assembly|
|oxidation-reduction process|
|protein phosphorylation|
|mitochondrion|
|phosphorylation|
|RNA binding|
|protein-containing complex assembly|
|positive regulation of cellular protein metabolic process|
|positive regulation of protein metabolic process|
|protein-containing complex subunit organization|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp346|CoCl2 18μM R07 exp346]]|1.7|
|[[:results:exp147|Resveratrol 16μM R03 exp147]]|1.71|
|[[:results:exp357|Dorsomorphin 5μM R07 exp357]]|1.76|
|[[:results:exp189|Temozolomide 200μM R04 exp189]]|1.8|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|1.8|
|[[:results:exp32|Rifampicin 10μM R00 exp32]]|1.81|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|1.82|
|[[:results:exp287|HMS-I2 5μM R06 exp287]]|1.84|
|[[:results:exp454|Bafilomycin-A1 0.009μM R08 exp454]]|1.89|
|[[:results:exp89|Vemurafenib 6.6μM R02 exp89]]|1.96|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|2.01|
|[[:results:exp29|Rapamycin 1μM R00 exp29]]|2.03|
|[[:results:exp360|Genistein 15μM R07 exp360]]|2.08|
|[[:results:exp470|Chloroquine 32μM R08 exp470]]|2.29|
|[[:results:exp460|BML-284 0.09μM R08 exp460]]|2.38|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|2.83|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|2.98|
|[[:results:exp288|HMS-I2 10μM R06 exp288]]|2.99|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:g:grsf1|GRSF1]]|0.628|
|[[:human genes:n:ndufa11|NDUFA11]]|0.607|
|[[:human genes:a:acad9|ACAD9]]|0.603|
|[[:human genes:m:mto1|MTO1]]|0.595|
|[[:human genes:r:rmnd1|RMND1]]|0.581|
|[[:human genes:m:mtif2|MTIF2]]|0.581|
|[[:human genes:m:mettl17|METTL17]]|0.574|
|[[:human genes:m:mtrf1l|MTRF1L]]|0.572|
|[[:human genes:r:rpusd3|RPUSD3]]|0.57|
|[[:human genes:g:gtpbp10|GTPBP10]]|0.563|
|[[:human genes:n:ndufaf7|NDUFAF7]]|0.563|
|[[:human genes:n:ndufaf3|NDUFAF3]]|0.559|
|[[:human genes:n:nubpl|NUBPL]]|0.557|
|[[:human genes:n:ndufb10|NDUFB10]]|0.556|
|[[:human genes:n:ndufa1|NDUFA1]]|0.555|
|[[:human genes:n:ndufaf5|NDUFAF5]]|0.554|
|[[:human genes:l:lars2|LARS2]]|0.552|
|[[:human genes:n:ndufs2|NDUFS2]]|0.55|
|[[:human genes:n:ndufb11|NDUFB11]]|0.55|
|[[:human genes:n:ndufa2|NDUFA2]]|0.548|
|[[:human genes:n:nsun4|NSUN4]]|0.547|
|[[:human genes:p:pet117|PET117]]|0.547|
|[[:human genes:p:pet112|PET112]]|0.545|
|[[:human genes:p:prepl|PREPL]]|0.544|
|[[:human genes:e:eral1|ERAL1]]|0.541|
|[[:human genes:n:ndufaf6|NDUFAF6]]|0.54|
|[[:human genes:n:ndufc1|NDUFC1]]|0.54|
|[[:human genes:d:ddx28|DDX28]]|0.537|
|[[:human genes:c:chchd1|CHCHD1]]|0.536|
|[[:human genes:n:ndufa3|NDUFA3]]|0.534|
|[[:human genes:f:ftsj2|FTSJ2]]|0.533|
|[[:human genes:c:coq2|COQ2]]|0.532|
|[[:human genes:x:xpnpep3|XPNPEP3]]|0.531|
|[[:human genes:t:tfb1m|TFB1M]]|0.531|
|[[:human genes:m:mcat|MCAT]]|0.529|
|[[:human genes:m:mrpl45|MRPL45]]|0.528|
|[[:human genes:h:hmgxb3|HMGXB3]]|0.527|
|[[:human genes:g:gfm2|GFM2]]|0.526|
|[[:human genes:s:ssbp1|SSBP1]]|0.524|
|[[:human genes:c:clpp|CLPP]]|0.523|
|[[:human genes:c:cars2|CARS2]]|0.521|
|[[:human genes:c:coq7|COQ7]]|0.521|
|[[:human genes:m:mpv17l2|MPV17L2]]|0.52|
|[[:human genes:m:mrpl1|MRPL1]]|0.518|
|[[:human genes:s:sfxn4|SFXN4]]|0.517|
|[[:human genes:t:timmdc1|TIMMDC1]]|0.515|
|[[:human genes:m:mterfd1|MTERFD1]]|0.512|
|[[:human genes:f:foxred1|FOXRED1]]|0.512|
|[[:human genes:n:ndufb9|NDUFB9]]|0.509|
|[[:human genes:m:mrps27|MRPS27]]|0.508|
|[[:human genes:g:gtpbp6|GTPBP6]]|0.507|
|[[:human genes:n:ndufs5|NDUFS5]]|0.506|
|[[:human genes:n:ndufc2|NDUFC2]]|0.503|
|[[:human genes:m:mrps21|MRPS21]]|0.502|
|[[:human genes:p:pde12|PDE12]]|0.502|
|[[:human genes:m:malsu1|MALSU1]]|0.499|
|[[:human genes:a:atp5sl|ATP5SL]]|0.499|
|[[:human genes:m:mtg1|MTG1]]|0.495|
|[[:human genes:c:c12orf65|C12orf65]]|0.492|
|[[:human genes:e:ecsit|ECSIT]]|0.491|
|[[:human genes:n:nars2|NARS2]]|0.49|
|[[:human genes:g:gfm1|GFM1]]|0.49|
|[[:human genes:i:iba57|IBA57]]|0.487|
|[[:human genes:q:qrsl1|QRSL1]]|0.486|
|[[:human genes:m:mrpl22|MRPL22]]|0.479|
|[[:human genes:n:ndufb7|NDUFB7]]|0.478|
|[[:human genes:p:ptcd3|PTCD3]]|0.478|
|[[:human genes:n:ndufa8|NDUFA8]]|0.476|
|[[:human genes:n:ndufaf1|NDUFAF1]]|0.475|
|[[:human genes:m:mrpl4|MRPL4]]|0.472|
|[[:human genes:n:ndufb6|NDUFB6]]|0.47|
|[[:human genes:m:mtg2|MTG2]]|0.469|
|[[:human genes:n:noa1|NOA1]]|0.467|
|[[:human genes:m:mcur1|MCUR1]]|0.462|
|[[:human genes:n:nsun3|NSUN3]]|0.462|
|[[:human genes:t:trit1|TRIT1]]|0.461|
|[[:human genes:r:rnmtl1|RNMTL1]]|0.461|
|[[:human genes:n:ndufa10|NDUFA10]]|0.459|
|[[:human genes:m:mrps10|MRPS10]]|0.458|
|[[:human genes:n:ndufs8|NDUFS8]]|0.457|
|[[:human genes:r:rbfa|RBFA]]|0.457|
|[[:human genes:m:mrpl53|MRPL53]]|0.456|
|[[:human genes:g:gtpbp8|GTPBP8]]|0.456|
|[[:human genes:c:ccdc90b|CCDC90B]]|0.456|
|[[:human genes:n:ndufv1|NDUFV1]]|0.454|
|[[:human genes:n:ndufv2|NDUFV2]]|0.453|
|[[:human genes:l:lrpprc|LRPPRC]]|0.453|
|[[:human genes:n:ndufaf4|NDUFAF4]]|0.452|
|[[:human genes:m:mrpl21|MRPL21]]|0.452|
|[[:human genes:r:rtn4ip1|RTN4IP1]]|0.452|
|[[:human genes:c:coa3|COA3]]|0.451|
|[[:human genes:w:wars2|WARS2]]|0.451|
|[[:human genes:n:ndufb2|NDUFB2]]|0.449|
|[[:human genes:i:ict1|ICT1]]|0.449|
|[[:human genes:m:mrps25|MRPS25]]|0.448|
|[[:human genes:t:timm17a|TIMM17A]]|0.447|
|[[:human genes:n:ndufb5|NDUFB5]]|0.446|
|[[:human genes:n:ndufs3|NDUFS3]]|0.443|
|[[:human genes:t:tomm7|TOMM7]]|0.441|
|[[:human genes:p:polrmt|POLRMT]]|0.44|
|[[:human genes:c:coa6|COA6]]|0.44|
|[[:human genes:n:ndufa6|NDUFA6]]|0.44|
|[[:human genes:p:polg2|POLG2]]|0.44|
|[[:human genes:e:ears2|EARS2]]|0.439|
|[[:human genes:m:mrpl23|MRPL23]]|0.438|
|[[:human genes:m:mrps5|MRPS5]]|0.436|
|[[:human genes:c:c1qbp|C1QBP]]|0.436|
|[[:human genes:n:ndufb4|NDUFB4]]|0.436|
|[[:human genes:a:aars2|AARS2]]|0.435|
|[[:human genes:m:mrp63|MRP63]]|0.435|
|[[:human genes:a:aifm1|AIFM1]]|0.434|
|[[:human genes:m:mrpl28|MRPL28]]|0.433|
|[[:human genes:m:mrpl43|MRPL43]]|0.433|
|[[:human genes:m:mrpl44|MRPL44]]|0.433|
|[[:human genes:t:timm8b|TIMM8B]]|0.432|
|[[:human genes:m:mrps6|MRPS6]]|0.431|
|[[:human genes:m:mrps35|MRPS35]]|0.43|
|[[:human genes:r:rpusd4|RPUSD4]]|0.429|
|[[:human genes:p:pars2|PARS2]]|0.429|
|[[:human genes:m:mrpl2|MRPL2]]|0.429|
|[[:human genes:m:mrpl17|MRPL17]]|0.429|
|[[:human genes:m:mrpl49|MRPL49]]|0.426|
|[[:human genes:m:mrpl3|MRPL3]]|0.425|
|[[:human genes:n:ndufb8|NDUFB8]]|0.425|
|[[:human genes:m:mterfd2|MTERFD2]]|0.423|
|[[:human genes:t:tars2|TARS2]]|0.422|
|[[:human genes:t:tsfm|TSFM]]|0.421|
|[[:human genes:r:rnaseh1|RNASEH1]]|0.419|
|[[:human genes:m:mipep|MIPEP]]|0.418|
|[[:human genes:c:cox18|COX18]]|0.418|
|[[:human genes:m:mrps18b|MRPS18B]]|0.417|
|[[:human genes:m:mrps12|MRPS12]]|0.417|
|[[:human genes:m:mrpl47|MRPL47]]|0.417|
|[[:human genes:d:dap3|DAP3]]|0.416|
|[[:human genes:m:mrpl12|MRPL12]]|0.416|
|[[:human genes:t:tmem261|TMEM261]]|0.416|
|[[:human genes:m:mrps16|MRPS16]]|0.414|
|[[:human genes:m:mrpl13|MRPL13]]|0.413|
|[[:human genes:w:wbscr16|WBSCR16]]|0.413|
|[[:human genes:s:selrc1|SELRC1]]|0.411|
|[[:human genes:t:trub2|TRUB2]]|0.41|
|[[:human genes:m:mars2|MARS2]]|0.408|
|[[:human genes:m:mrpl48|MRPL48]]|0.407|
|[[:human genes:m:mrps34|MRPS34]]|0.407|
|[[:human genes:m:mdh2|MDH2]]|0.407|
|[[:human genes:m:mrps22|MRPS22]]|0.407|
|[[:human genes:f:fastkd5|FASTKD5]]|0.406|
|[[:human genes:h:hsd17b10|HSD17B10]]|0.406|
|[[:human genes:m:mrpl15|MRPL15]]|0.401|
|[[:human genes:s:slc30a9|SLC30A9]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1329
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.12 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='FASTKD2 Expression in NALM6 Cells: 6.12'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>