======= FASTKD5 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: FASTKD5
  * **<color #00a2e8>Official Name</color>**: FAST kinase domains 5
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=60493|60493]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q7L8L6|Q7L8L6]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=FASTKD5&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20FASTKD5|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/614272|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Plays an important role in the processing of non- canonical mitochondrial mRNA precursors (PubMed:25683715). {ECO:0000269|PubMed:25683715}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|FAST 2|
|RAP|
|FAST 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|ribonucleoprotein granule|
|mitochondrial RNA processing|
|rRNA binding|
|mitochondrial RNA metabolic process|
|mitochondrial nucleoid|
|mitochondrial gene expression|
|cellular respiration|
|energy derivation by oxidation of organic compounds|
|protein kinase activity|
|generation of precursor metabolites and energy|
|mRNA processing|
|mRNA metabolic process|
|RNA processing|
|oxidation-reduction process|
|protein phosphorylation|
|mitochondrion|
|phosphorylation|
|RNA binding|
|RNA metabolic process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp191|Hypoxia 5%O2 R04 exp191]]|-3.05|
|[[:results:exp288|HMS-I2 10μM R06 exp288]]|-2.47|
|[[:results:exp101|Nicotinamide 1000μM R03 exp101]]|-2.32|
|[[:results:exp261|ABT-702 5μM R06 exp261]]|-2.03|
|[[:results:exp232|Epothilone-D 0.004 to 0.006μM on day4 R05 exp232]]|-1.95|
|[[:results:exp114|A-196 10μM R03 exp114]]|-1.93|
|[[:results:exp437|Ethanol 0.003 R08 exp437]]|-1.93|
|[[:results:exp420|Tunicamycin 0.04 to 0.125μM  on day4 R07 exp420]]|-1.92|
|[[:results:exp317|Geldanamycin 0.015 to 0.05μM on day4 R07 exp317]]|-1.88|
|[[:results:exp455|Benzoate 10000μM R08 exp455]]|-1.87|
|[[:results:exp164|Q15 1 to 2μM on day4 R04 exp164]]|-1.86|
|[[:results:exp140|Nicotinate 1000μM R03 exp140]]|-1.83|
|[[:results:exp533|TNF-alpha 44ng/ml R08 exp533]]|-1.81|
|[[:results:exp182|IU1-47 25μM R04 exp182]]|-1.76|
|[[:results:exp287|HMS-I2 5μM R06 exp287]]|-1.7|
|[[:results:exp454|Bafilomycin-A1 0.009μM R08 exp454]]|1.72|
|[[:results:exp357|Dorsomorphin 5μM R07 exp357]]|1.77|
|[[:results:exp487|Hinokiflavone 12μM R08 exp487]]|1.79|
|[[:results:exp536|Vitamin-D3 40μM R08 exp536]]|2.08|
|[[:results:exp290|LLY-283 2.6μM R06 exp290]]|2.12|
|[[:results:exp521|Salinomycin 3.5μM R08 exp521]]|2.12|
|[[:results:exp532|TIC10 10μM R08 exp532]]|2.32|
|[[:results:exp513|ONC212 0.15μM R08 exp513]]|2.49|
|[[:results:exp468|CB-5083 0.4μM R08 exp468]]|2.5|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|2.78|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|2.82|
|[[:results:exp431|Rotenone 0.07μM R08 exp431]]|3.1|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:s:selrc1|SELRC1]]|0.718|
|[[:human genes:m:mrpl23|MRPL23]]|0.694|
|[[:human genes:y:yars2|YARS2]]|0.676|
|[[:human genes:m:mrpl21|MRPL21]]|0.674|
|[[:human genes:m:mrps21|MRPS21]]|0.674|
|[[:human genes:m:mrps6|MRPS6]]|0.668|
|[[:human genes:h:hsd17b10|HSD17B10]]|0.667|
|[[:human genes:e:ears2|EARS2]]|0.663|
|[[:human genes:c:cox16|COX16]]|0.663|
|[[:human genes:d:dap3|DAP3]]|0.66|
|[[:human genes:s:sco2|SCO2]]|0.659|
|[[:human genes:m:mrps5|MRPS5]]|0.657|
|[[:human genes:r:rpusd4|RPUSD4]]|0.654|
|[[:human genes:n:nars2|NARS2]]|0.651|
|[[:human genes:t:tars2|TARS2]]|0.649|
|[[:human genes:c:coa3|COA3]]|0.645|
|[[:human genes:m:mrps16|MRPS16]]|0.643|
|[[:human genes:q:qrsl1|QRSL1]]|0.641|
|[[:human genes:v:vars2|VARS2]]|0.634|
|[[:human genes:m:mrpl47|MRPL47]]|0.632|
|[[:human genes:m:mrps34|MRPS34]]|0.627|
|[[:human genes:m:mrps18a|MRPS18A]]|0.624|
|[[:human genes:p:pars2|PARS2]]|0.621|
|[[:human genes:m:mrps2|MRPS2]]|0.617|
|[[:human genes:g:gatc|GATC]]|0.615|
|[[:human genes:m:mrpl53|MRPL53]]|0.613|
|[[:human genes:c:coa6|COA6]]|0.609|
|[[:human genes:m:mrps14|MRPS14]]|0.608|
|[[:human genes:r:rars2|RARS2]]|0.607|
|[[:human genes:m:mtg2|MTG2]]|0.605|
|[[:human genes:b:bcs1l|BCS1L]]|0.603|
|[[:human genes:c:cox15|COX15]]|0.601|
|[[:human genes:r:rbfa|RBFA]]|0.601|
|[[:human genes:s:sars2|SARS2]]|0.6|
|[[:human genes:p:pet112|PET112]]|0.599|
|[[:human genes:c:cox7b|COX7B]]|0.596|
|[[:human genes:c:c10orf2|C10orf2]]|0.595|
|[[:human genes:g:gfm1|GFM1]]|0.595|
|[[:human genes:m:mrp63|MRP63]]|0.588|
|[[:human genes:h:hars2|HARS2]]|0.586|
|[[:human genes:l:lars2|LARS2]]|0.58|
|[[:human genes:r:rnaseh1|RNASEH1]]|0.577|
|[[:human genes:c:c12orf65|C12orf65]]|0.576|
|[[:human genes:m:mrps10|MRPS10]]|0.576|
|[[:human genes:m:mrps26|MRPS26]]|0.575|
|[[:human genes:m:mrps24|MRPS24]]|0.57|
|[[:human genes:m:mtpap|MTPAP]]|0.569|
|[[:human genes:g:gtpbp10|GTPBP10]]|0.567|
|[[:human genes:d:dars2|DARS2]]|0.567|
|[[:human genes:t:tufm|TUFM]]|0.566|
|[[:human genes:a:aars2|AARS2]]|0.561|
|[[:human genes:p:pdss1|PDSS1]]|0.561|
|[[:human genes:m:mrpl12|MRPL12]]|0.561|
|[[:human genes:m:mtg1|MTG1]]|0.556|
|[[:human genes:t:tmem242|TMEM242]]|0.553|
|[[:human genes:c:cox11|COX11]]|0.552|
|[[:human genes:m:mars2|MARS2]]|0.55|
|[[:human genes:t:tefm|TEFM]]|0.547|
|[[:human genes:k:kiaa0391|KIAA0391]]|0.544|
|[[:human genes:t:trub2|TRUB2]]|0.544|
|[[:human genes:p:pgm3|PGM3]]|0.543|
|[[:human genes:f:ftsj2|FTSJ2]]|0.542|
|[[:human genes:m:mrps25|MRPS25]]|0.542|
|[[:human genes:w:wbscr16|WBSCR16]]|0.539|
|[[:human genes:c:cox6c|COX6C]]|0.537|
|[[:human genes:m:mrpl45|MRPL45]]|0.537|
|[[:human genes:s:supv3l1|SUPV3L1]]|0.537|
|[[:human genes:p:pet117|PET117]]|0.537|
|[[:human genes:l:lsm10|LSM10]]|0.536|
|[[:human genes:c:cox17|COX17]]|0.534|
|[[:human genes:m:mterfd2|MTERFD2]]|0.533|
|[[:human genes:m:mrps9|MRPS9]]|0.531|
|[[:human genes:d:dhrsx|DHRSX]]|0.531|
|[[:human genes:m:mrps12|MRPS12]]|0.53|
|[[:human genes:g:gfm2|GFM2]]|0.526|
|[[:human genes:m:mrpl55|MRPL55]]|0.526|
|[[:human genes:p:pet100|PET100]]|0.524|
|[[:human genes:p:polg2|POLG2]]|0.523|
|[[:human genes:m:mrpl34|MRPL34]]|0.521|
|[[:human genes:m:mrpl43|MRPL43]]|0.52|
|[[:human genes:m:mrps35|MRPS35]]|0.519|
|[[:human genes:c:chchd4|CHCHD4]]|0.519|
|[[:human genes:c:coa5|COA5]]|0.518|
|[[:human genes:m:mrpl3|MRPL3]]|0.517|
|[[:human genes:m:mrpl15|MRPL15]]|0.513|
|[[:human genes:f:fars2|FARS2]]|0.512|
|[[:human genes:n:ndufaf7|NDUFAF7]]|0.512|
|[[:human genes:p:pnpt1|PNPT1]]|0.511|
|[[:human genes:a:atp5d|ATP5D]]|0.51|
|[[:human genes:n:ndufb11|NDUFB11]]|0.508|
|[[:human genes:m:mtrf1l|MTRF1L]]|0.505|
|[[:human genes:l:lrpprc|LRPPRC]]|0.505|
|[[:human genes:n:ndufa3|NDUFA3]]|0.503|
|[[:human genes:s:slc25a26|SLC25A26]]|0.501|
|[[:human genes:m:mrpl18|MRPL18]]|0.5|
|[[:human genes:m:mrpl4|MRPL4]]|0.498|
|[[:human genes:m:mrpl20|MRPL20]]|0.496|
|[[:human genes:c:coq2|COQ2]]|0.495|
|[[:human genes:m:mettl17|METTL17]]|0.494|
|[[:human genes:a:atp5c1|ATP5C1]]|0.494|
|[[:human genes:p:polg|POLG]]|0.494|
|[[:human genes:m:mrpl44|MRPL44]]|0.485|
|[[:human genes:c:coq4|COQ4]]|0.485|
|[[:human genes:m:mrpl11|MRPL11]]|0.484|
|[[:human genes:c:cox6b1|COX6B1]]|0.484|
|[[:human genes:d:dhx30|DHX30]]|0.483|
|[[:human genes:m:mrps33|MRPS33]]|0.481|
|[[:human genes:u:uqcrc2|UQCRC2]]|0.481|
|[[:human genes:m:mipep|MIPEP]]|0.476|
|[[:human genes:m:mrpl22|MRPL22]]|0.476|
|[[:human genes:m:mrps23|MRPS23]]|0.474|
|[[:human genes:a:atp5a1|ATP5A1]]|0.474|
|[[:human genes:u:uqcr10|UQCR10]]|0.473|
|[[:human genes:d:dnlz|DNLZ]]|0.472|
|[[:human genes:n:ndufa2|NDUFA2]]|0.471|
|[[:human genes:r:rpusd3|RPUSD3]]|0.471|
|[[:human genes:m:mrps11|MRPS11]]|0.471|
|[[:human genes:t:tbrg4|TBRG4]]|0.468|
|[[:human genes:c:chchd1|CHCHD1]]|0.465|
|[[:human genes:w:wars2|WARS2]]|0.464|
|[[:human genes:c:c17orf89|C17orf89]]|0.463|
|[[:human genes:m:mtif3|MTIF3]]|0.463|
|[[:human genes:c:coq7|COQ7]]|0.46|
|[[:human genes:p:polrmt|POLRMT]]|0.459|
|[[:human genes:u:uqcc2|UQCC2]]|0.458|
|[[:human genes:m:mrpl2|MRPL2]]|0.458|
|[[:human genes:n:ndufaf4|NDUFAF4]]|0.455|
|[[:human genes:t:triap1|TRIAP1]]|0.455|
|[[:human genes:c:cycs|CYCS]]|0.454|
|[[:human genes:o:opa1|OPA1]]|0.453|
|[[:human genes:n:ndufc2|NDUFC2]]|0.452|
|[[:human genes:m:mrpl42|MRPL42]]|0.451|
|[[:human genes:c:cars2|CARS2]]|0.451|
|[[:human genes:n:ndufb3|NDUFB3]]|0.451|
|[[:human genes:s:ssbp1|SSBP1]]|0.449|
|[[:human genes:t:timm8b|TIMM8B]]|0.449|
|[[:human genes:a:atp5b|ATP5B]]|0.449|
|[[:human genes:n:ndufb5|NDUFB5]]|0.448|
|[[:human genes:c:cox20|COX20]]|0.448|
|[[:human genes:t:tomm20|TOMM20]]|0.448|
|[[:human genes:m:mrpl1|MRPL1]]|0.446|
|[[:human genes:c:clpp|CLPP]]|0.446|
|[[:human genes:t:tomm22|TOMM22]]|0.446|
|[[:human genes:d:ddx28|DDX28]]|0.446|
|[[:human genes:n:ndufa1|NDUFA1]]|0.444|
|[[:human genes:n:ndufs7|NDUFS7]]|0.444|
|[[:human genes:m:mrpl49|MRPL49]]|0.444|
|[[:human genes:m:mrps7|MRPS7]]|0.443|
|[[:human genes:u:uqcrc1|UQCRC1]]|0.443|
|[[:human genes:m:mcat|MCAT]]|0.443|
|[[:human genes:h:hccs|HCCS]]|0.44|
|[[:human genes:a:aifm1|AIFM1]]|0.44|
|[[:human genes:m:mrpl36|MRPL36]]|0.44|
|[[:human genes:r:rpia|RPIA]]|0.439|
|[[:human genes:m:mrps22|MRPS22]]|0.438|
|[[:human genes:n:ndufv1|NDUFV1]]|0.438|
|[[:human genes:c:coq3|COQ3]]|0.437|
|[[:human genes:a:alg8|ALG8]]|0.436|
|[[:human genes:m:mrpl46|MRPL46]]|0.435|
|[[:human genes:n:ndufs2|NDUFS2]]|0.435|
|[[:human genes:c:cox19|COX19]]|0.435|
|[[:human genes:c:cox5a|COX5A]]|0.434|
|[[:human genes:m:mrpl41|MRPL41]]|0.434|
|[[:human genes:a:atp5sl|ATP5SL]]|0.434|
|[[:human genes:t:tamm41|TAMM41]]|0.434|
|[[:human genes:f:fh|FH]]|0.433|
|[[:human genes:r:rtn4ip1|RTN4IP1]]|0.432|
|[[:human genes:m:mrps17|MRPS17]]|0.432|
|[[:human genes:m:mrpl33|MRPL33]]|0.43|
|[[:human genes:m:mrps28|MRPS28]]|0.428|
|[[:human genes:h:hmgxb3|HMGXB3]]|0.428|
|[[:human genes:m:mrpl13|MRPL13]]|0.425|
|[[:human genes:a:aasdhppt|AASDHPPT]]|0.422|
|[[:human genes:p:ptpmt1|PTPMT1]]|0.421|
|[[:human genes:p:ptcd3|PTCD3]]|0.419|
|[[:human genes:m:mto1|MTO1]]|0.418|
|[[:human genes:p:pgs1|PGS1]]|0.418|
|[[:human genes:e:elac2|ELAC2]]|0.418|
|[[:human genes:h:higd2a|HIGD2A]]|0.416|
|[[:human genes:m:mrps27|MRPS27]]|0.415|
|[[:human genes:g:gars|GARS]]|0.415|
|[[:human genes:m:mrpl39|MRPL39]]|0.414|
|[[:human genes:e:ecsit|ECSIT]]|0.413|
|[[:human genes:p:pmvk|PMVK]]|0.413|
|[[:human genes:a:acad9|ACAD9]]|0.412|
|[[:human genes:t:tfam|TFAM]]|0.412|
|[[:human genes:i:iba57|IBA57]]|0.412|
|[[:human genes:m:mrpl37|MRPL37]]|0.411|
|[[:human genes:m:malsu1|MALSU1]]|0.41|
|[[:human genes:g:gemin7|GEMIN7]]|0.41|
|[[:human genes:f:fastkd2|FASTKD2]]|0.406|
|[[:human genes:u:uqcrq|UQCRQ]]|0.406|
|[[:human genes:t:taz|TAZ]]|0.406|
|[[:human genes:m:minos1|MINOS1]]|0.405|
|[[:human genes:m:mrpl51|MRPL51]]|0.403|
|[[:human genes:n:ndufb6|NDUFB6]]|0.403|
|[[:human genes:c:c11orf57|C11orf57]]|0.402|
|[[:human genes:m:mtif2|MTIF2]]|0.402|
|[[:human genes:t:tomm40|TOMM40]]|0.4|
|[[:human genes:b:brwd1|BRWD1]]|0.4|
|[[:human genes:a:atp5h|ATP5H]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 23/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|1/28|
|blood|1/28|
|bone|1/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|1/4|
|colorectal|1/17|
|esophagus|2/13|
|fibroblast|0/1|
|gastric|1/16|
|kidney|1/21|
|liver|0/20|
|lung|3/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|1/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|1/9|
|thyroid|0/2|
|upper aerodigestive|1/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1660
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.42 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='FASTKD5 Expression in NALM6 Cells: 5.42'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>