======= FAT4 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: FAT4
  * **<color #00a2e8>Official Name</color>**: FAT atypical cadherin 4
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=79633|79633]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q6V0I7|Q6V0I7]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=FAT4&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20FAT4|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/612411|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a member of the protocadherin family. This gene may play a role in regulating planar cell polarity (PCP). Studies in mice suggest that loss of PCP signaling may cause cystic kidney disease, and mutations in this gene have been associated with Van Maldergem Syndrome 2. Alternatively spliced transcript variants have been noted for this gene. [provided by RefSeq, Mar 2014]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Cadherins are calcium-dependent cell adhesion proteins. FAT4 plays a role in the maintenance of planar cell polarity as well as in inhibition of YAP1-mediated neuroprogenitor cell proliferation and differentiation (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|EGF|
|Laminin G 2|
|Laminin G 1|
|Cadherin|
|EGF CA|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|condensed mesenchymal cell proliferation|
|regulation of metanephric nephron tubule epithelial cell differentiation|
|regulation of nephron tubule epithelial cell differentiation|
|ossification involved in bone maturation|
|mesenchymal cell proliferation|
|bone maturation|
|regulation of epithelial cell differentiation involved in kidney development|
|animal organ maturation|
|regulation of metanephros development|
|hippo signaling|
|inner ear receptor cell stereocilium organization|
|inner ear receptor cell development|
|branching involved in ureteric bud morphogenesis|
|heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules|
|inner ear receptor cell differentiation|
|ureteric bud morphogenesis|
|mesonephric tubule morphogenesis|
|regulation of kidney development|
|mechanoreceptor differentiation|
|nephron tubule morphogenesis|
|nephron epithelium morphogenesis|
|nephron morphogenesis|
|renal tubule morphogenesis|
|apical part of cell|
|nephron tubule development|
|fibroblast growth factor receptor signaling pathway|
|renal tubule development|
|kidney morphogenesis|
|ureteric bud development|
|mesonephric tubule development|
|mesonephric epithelium development|
|mesonephros development|
|plasma membrane organization|
|nephron epithelium development|
|cellular response to fibroblast growth factor stimulus|
|response to fibroblast growth factor|
|cerebral cortex development|
|nephron development|
|Notch signaling pathway|
|kidney epithelium development|
|branching morphogenesis of an epithelial tube|
|digestive tract development|
|anatomical structure maturation|
|regulation of epithelial cell differentiation|
|digestive system development|
|morphogenesis of a branching epithelium|
|morphogenesis of a branching structure|
|homophilic cell adhesion via plasma membrane adhesion molecules|
|pallium development|
|inner ear development|
|bone development|
|ear development|
|developmental maturation|
|heart morphogenesis|
|telencephalon development|
|cell-cell adhesion via plasma-membrane adhesion molecules|
|ossification|
|kidney development|
|renal system development|
|epithelial tube morphogenesis|
|urogenital system development|
|forebrain development|
|endomembrane system organization|
|morphogenesis of an epithelium|
|skeletal system development|
|cellular response to growth factor stimulus|
|cell-cell adhesion|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|heart development|
|response to growth factor|
|sensory organ development|
|cell population proliferation|
|tissue morphogenesis|
|tube morphogenesis|
|neuron projection development|
|enzyme linked receptor protein signaling pathway|
|calcium ion binding|
|brain development|
|head development|
|neuron development|
|tube development|
|membrane organization|
|circulatory system development|
|cell adhesion|
|biological adhesion|
|animal organ morphogenesis|
|central nervous system development|
|neuron differentiation|
|epithelium development|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|cellular response to endogenous stimulus|
|response to endogenous stimulus|
|generation of neurons|
|neurogenesis|
|cell development|
|intracellular signal transduction|
|tissue development|
|regulation of cell differentiation|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8982
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -7.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='FAT4 Expression in NALM6 Cells: -7.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>