======= FBL =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: FBL
  * **<color #00a2e8>Official Name</color>**: fibrillarin
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2091|2091]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P22087|P22087]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=FBL&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20FBL|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/134795|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  S-adenosyl-L-methionine-dependent methyltransferase that has the ability to methylate both RNAs and proteins. Involved in pre-rRNA processing by catalyzing the site-specific 2'-hydroxyl methylation of ribose moieties in pre-ribosomal RNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA. Also acts as a protein methyltransferase by mediating methylation of 'Gln-105' of histone H2A (H2AQ104me), a modification that impairs binding of the FACT complex and is specifically present at 35S ribosomal DNA locus (PubMed:24352239). {ECO:0000269|PubMed:24352239}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Fibrillarin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|histone glutamine methylation|
|box C/D snoRNA processing|
|box C/D snoRNA metabolic process|
|rRNA methyltransferase activity|
|histone-glutamine methyltransferase activity|
|dense fibrillar component|
|box C/D snoRNA 3-end processing|
|peptidyl-glutamine methylation|
|granular component|
|snoRNA localization|
|box C/D snoRNP complex|
|TFIID-class transcription factor complex binding|
|snoRNA 3-end processing|
|snoRNA processing|
|snoRNA metabolic process|
|rRNA methylation|
|rRNA modification|
|small-subunit processome|
|ncRNA 3-end processing|
|Cajal body|
|ATPase binding|
|RNA methylation|
|histone methylation|
|chromosome|
|osteoblast differentiation|
|fibrillar center|
|protein alkylation|
|protein methylation|
|RNA 3-end processing|
|RNA modification|
|rRNA processing|
|RNA localization|
|rRNA metabolic process|
|macromolecule methylation|
|ossification|
|ribosome biogenesis|
|methylation|
|histone modification|
|covalent chromatin modification|
|ncRNA processing|
|ribonucleoprotein complex biogenesis|
|ncRNA metabolic process|
|chromatin organization|
|nucleolus|
|RNA processing|
|chromosome organization|
|RNA binding|
|RNA metabolic process|
|membrane|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|-1.95|
|[[:results:exp22|MLN-4924 2μM R00 exp22]]|-1.78|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|-1.7|
|[[:results:exp52|Ribavirin 10μM R01 exp52]]|1.82|
|[[:results:exp249|Vinorelbine 0.001μM R05 exp249]]|1.89|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:prim1|PRIM1]]|0.62|
|[[:human genes:p:polr2j3|POLR2J3]]|0.503|
|[[:human genes:c:c14orf93|C14orf93]]|0.47|
|[[:human genes:s:s1pr4|S1PR4]]|0.457|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.447|
|[[:human genes:r:rps7|RPS7]]|0.441|
|[[:human genes:s:slc38a7|SLC38A7]]|0.431|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.429|
|[[:human genes:p:pan2|PAN2]]|0.421|
|[[:human genes:r:rrm1|RRM1]]|0.418|
|[[:human genes:c:col2a1|COL2A1]]|0.417|
|[[:human genes:p:psmd14|PSMD14]]|0.416|
|[[:human genes:p:psmb2|PSMB2]]|0.405|
|[[:human genes:r:rrp7a|RRP7A]]|0.405|
|[[:human genes:t:tp53tg3|TP53TG3]]|0.402|
|[[:human genes:t:tp53tg3c|TP53TG3C]]|0.402|
|[[:human genes:t:tceb3c|TCEB3C]]|0.402|
|[[:human genes:t:tp53tg3b|TP53TG3B]]|0.402|
|[[:human genes:s:supt6h|SUPT6H]]|0.401|
|[[:human genes:r:ruvbl2|RUVBL2]]|0.401|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 719/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|28/28|
|blood|27/28|
|bone|25/25|
|breast|33/33|
|central nervous system|55/56|
|cervix|4/4|
|colorectal|17/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|15/15|
|kidney|21/21|
|liver|20/20|
|lung|73/75|
|lymphocyte|14/14|
|ovary|26/26|
|pancreas|23/24|
|peripheral nervous system|16/16|
|plasma cell|15/15|
|prostate|1/1|
|skin|24/24|
|soft tissue|7/7|
|thyroid|2/2|
|upper aerodigestive|22/22|
|urinary tract|28/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 507
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.46 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='FBL Expression in NALM6 Cells: 7.46'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>