======= FBLN1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: FBLN1
  * **<color #00a2e8>Official Name</color>**: fibulin 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2192|2192]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P23142|P23142]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=FBLN1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20FBLN1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/135820|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Fibulin 1 is a secreted glycoprotein that becomes incorporated into a fibrillar extracellular matrix. Calcium-binding is apparently required to mediate its binding to laminin and nidogen. It mediates platelet adhesion via binding fibrinogen. Four splice variants which differ in the 3' end have been identified. Each variant encodes a different isoform, but no functional distinctions have been identified among the four variants. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|EGF CA|
|cEGF|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|elastic fiber|
|fibrinogen binding|
|peptidase activator activity|
|negative regulation of substrate adhesion-dependent cell spreading|
|negative regulation of stem cell proliferation|
|blood coagulation, fibrin clot formation|
|protein activation cascade|
|fibronectin binding|
|embryo implantation|
|regulation of substrate adhesion-dependent cell spreading|
|negative regulation of cell-substrate adhesion|
|regulation of stem cell proliferation|
|negative regulation of ERK1 and ERK2 cascade|
|basement membrane|
|integrin-mediated signaling pathway|
|negative regulation of cell morphogenesis involved in differentiation|
|extracellular matrix structural constituent|
|negative regulation of MAPK cascade|
|female pregnancy|
|protein C-terminus binding|
|positive regulation of peptidase activity|
|multi-multicellular organism process|
|regulation of cell-substrate adhesion|
|extracellular matrix|
|protein-containing complex binding|
|negative regulation of cell adhesion|
|negative regulation of cell motility|
|regulation of ERK1 and ERK2 cascade|
|blood coagulation|
|coagulation|
|hemostasis|
|regulation of cell morphogenesis involved in differentiation|
|negative regulation of cellular component movement|
|negative regulation of locomotion|
|negative regulation of cell development|
|extracellular matrix organization|
|positive regulation of proteolysis|
|collagen-containing extracellular matrix|
|extracellular structure organization|
|negative regulation of protein phosphorylation|
|negative regulation of phosphorylation|
|regulation of peptidase activity|
|wound healing|
|regulation of cell morphogenesis|
|regulation of body fluid levels|
|negative regulation of intracellular signal transduction|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|response to wounding|
|negative regulation of protein modification process|
|negative regulation of cell population proliferation|
|regulation of cell adhesion|
|viral process|
|negative regulation of cellular component organization|
|negative regulation of cell differentiation|
|calcium ion binding|
|regulation of proteolysis|
|regulation of MAPK cascade|
|positive regulation of hydrolase activity|
|symbiotic process|
|interspecies interaction between organisms|
|regulation of cell motility|
|regulation of cell development|
|negative regulation of developmental process|
|regulation of locomotion|
|multi-organism reproductive process|
|regulation of cellular component movement|
|negative regulation of cellular protein metabolic process|
|regulation of anatomical structure morphogenesis|
|identical protein binding|
|negative regulation of protein metabolic process|
|negative regulation of signal transduction|
|regulation of hydrolase activity|
|negative regulation of cell communication|
|negative regulation of signaling|
|reproductive process|
|reproduction|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|regulation of phosphorylation|
|extracellular space|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|positive regulation of protein metabolic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|extracellular region|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp14|Cycloheximide 0.02μM R00 exp14]]|-1.88|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13961
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.58 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='FBLN1 Expression in NALM6 Cells: 2.58'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>