======= FBP1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: FBP1
  * **<color #00a2e8>Official Name</color>**: fructose-bisphosphatase 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2203|2203]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P09467|P09467]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=FBP1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20FBP1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/611570|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Fructose-1,6-bisphosphatase 1, a gluconeogenesis regulatory enzyme, catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate and inorganic phosphate. Fructose-1,6-diphosphatase deficiency is associated with hypoglycemia and metabolic acidosis. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate in the presence of divalent cations, acting as a rate-limiting enzyme in gluconeogenesis. Plays a role in regulating glucose sensing and insulin secretion of pancreatic beta-cells. Appears to modulate glycerol gluconeogenesis in liver. Important regulator of appetite and adiposity; increased expression of the protein in liver after nutrient excess increases circulating satiety hormones and reduces appetite-stimulating neuropeptides and thus seems to provide a feedback mechanism to limit weight gain. {ECO:0000269|PubMed:16497803, ECO:0000269|PubMed:18375435, ECO:0000269|PubMed:22517657}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|FBPase|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|fructose 1,6-bisphosphate 1-phosphatase activity|
|sucrose biosynthetic process|
|sucrose metabolic process|
|disaccharide biosynthetic process|
|cellular response to magnesium ion|
|fructose 6-phosphate metabolic process|
|fructose 1,6-bisphosphate metabolic process|
|disaccharide metabolic process|
|AMP binding|
|negative regulation of glycolytic process|
|monosaccharide binding|
|fructose metabolic process|
|oligosaccharide biosynthetic process|
|negative regulation of purine nucleotide metabolic process|
|negative regulation of nucleotide metabolic process|
|response to magnesium ion|
|negative regulation of ATP metabolic process|
|negative regulation of cellular carbohydrate metabolic process|
|gluconeogenesis|
|regulation of gluconeogenesis|
|hexose biosynthetic process|
|negative regulation of carbohydrate metabolic process|
|oligosaccharide metabolic process|
|negative regulation of Ras protein signal transduction|
|monosaccharide biosynthetic process|
|cellular carbohydrate biosynthetic process|
|negative regulation of small GTPase mediated signal transduction|
|RNA polymerase II transcription factor binding|
|regulation of glycolytic process|
|regulation of carbohydrate catabolic process|
|negative regulation of small molecule metabolic process|
|protein homotetramerization|
|regulation of carbohydrate biosynthetic process|
|glucose metabolic process|
|regulation of glucose metabolic process|
|regulation of purine nucleotide metabolic process|
|regulation of nucleotide metabolic process|
|regulation of ATP metabolic process|
|carbohydrate biosynthetic process|
|regulation of cellular carbohydrate metabolic process|
|protein tetramerization|
|hexose metabolic process|
|regulation of generation of precursor metabolites and energy|
|cellular carbohydrate metabolic process|
|negative regulation of cell growth|
|cellular response to metal ion|
|monosaccharide metabolic process|
|regulation of carbohydrate metabolic process|
|cellular response to inorganic substance|
|negative regulation of growth|
|regulation of Ras protein signal transduction|
|dephosphorylation|
|negative regulation of catabolic process|
|protein homooligomerization|
|regulation of small GTPase mediated signal transduction|
|response to metal ion|
|cellular response to drug|
|regulation of cell growth|
|regulation of small molecule metabolic process|
|negative regulation of phosphorylation|
|carbohydrate metabolic process|
|negative regulation of intracellular signal transduction|
|protein complex oligomerization|
|response to inorganic substance|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|small molecule biosynthetic process|
|regulation of growth|
|negative regulation of transcription by RNA polymerase II|
|organophosphate metabolic process|
|regulation of catabolic process|
|response to drug|
|carbohydrate derivative metabolic process|
|identical protein binding|
|negative regulation of transcription, DNA-templated|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of signal transduction|
|negative regulation of RNA metabolic process|
|negative regulation of cell communication|
|negative regulation of signaling|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
|protein-containing complex assembly|
|regulation of phosphorylation|
|negative regulation of response to stimulus|
|negative regulation of gene expression|
|small molecule metabolic process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of intracellular signal transduction|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp449|Arsenic trioxide 60μM R08 exp449]]|1.73|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8943
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -7.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='FBP1 Expression in NALM6 Cells: -7.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>