======= FBXL20 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: FBXL20
  * **<color #00a2e8>Official Name</color>**: F-box and leucine rich repeat protein 20
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=84961|84961]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96IG2|Q96IG2]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=FBXL20&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20FBXL20|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/609086|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex. Role in neural transmission (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|F-box|
|F-box-like|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of protein catabolic process at presynapse, modulating synaptic transmission|
|presynaptic modulation of chemical synaptic transmission|
|behavioral fear response|
|behavioral defense response|
|fear response|
|SCF ubiquitin ligase complex|
|multicellular organismal response to stress|
|regulation of synaptic vesicle exocytosis|
|Schaffer collateral - CA1 synapse|
|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|
|presynapse|
|regulation of neurotransmitter secretion|
|regulation of synaptic vesicle cycle|
|regulation of neurotransmitter transport|
|regulation of regulated secretory pathway|
|regulation of exocytosis|
|ubiquitin-protein transferase activity|
|protein polyubiquitination|
|proteasome-mediated ubiquitin-dependent protein catabolic process|
|glutamatergic synapse|
|proteasomal protein catabolic process|
|regulation of neurotransmitter levels|
|post-translational protein modification|
|regulation of protein catabolic process|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|ubiquitin-dependent protein catabolic process|
|modification-dependent protein catabolic process|
|modification-dependent macromolecule catabolic process|
|regulation of vesicle-mediated transport|
|behavior|
|proteolysis involved in cellular protein catabolic process|
|cellular protein catabolic process|
|protein catabolic process|
|protein ubiquitination|
|regulation of secretion by cell|
|protein modification by small protein conjugation|
|regulation of secretion|
|cellular macromolecule catabolic process|
|regulation of cellular localization|
|protein modification by small protein conjugation or removal|
|regulation of catabolic process|
|macromolecule catabolic process|
|organonitrogen compound catabolic process|
|proteolysis|
|defense response|
|organic substance catabolic process|
|cellular catabolic process|
|regulation of transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp135|MS023 7μM R03 exp135]]|1.7|
|[[:results:exp535|Trimetrexate 0.03μM R08 exp535]]|1.7|
|[[:results:exp409|THZ531 0.11μM R07 exp409]]|1.71|
|[[:results:exp103|Taxol 0.004μM R03 exp103]]|1.8|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|1.81|
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|1.81|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|1.86|
|[[:results:exp292|Menadione 5μM R06 exp292]]|1.93|
|[[:results:exp14|Cycloheximide 0.02μM R00 exp14]]|1.95|
|[[:results:exp179|Combretastatin A4 0.002 to 0.003μM day4 R04 exp179]]|1.98|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|1.99|
|[[:results:exp301|VER-155008 3.9μM R06 exp301]]|2|
|[[:results:exp492|iCRT14 30μM R08 exp492]]|2.04|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|2.04|
|[[:results:exp410|THZ531 0.11 to 0.125μM on day4 R07 exp410]]|2.1|
|[[:results:exp228|Demecolcine 0.03μM R05 exp228]]|2.16|
|[[:results:exp412|THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412]]|2.17|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|2.25|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|2.25|
|[[:results:exp7|Bortezomib 0.05μM R00 exp7]]|2.54|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|2.82|
|[[:results:exp134|MS023 2μM R03 exp134]]|2.89|
|[[:results:exp413|THZ531 0.11 to 0.175μM on day4 R07 exp413]]|3.07|
|[[:results:exp444|THZ531 0.225μM R08 exp444]]|3.67|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 14307
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.36 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='FBXL20 Expression in NALM6 Cells: 5.36'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>