======= FBXO5 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: FBXO5
  * **<color #00a2e8>Official Name</color>**: F-box protein 5
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=26271|26271]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UKT4|Q9UKT4]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=FBXO5&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20FBXO5|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606013|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Regulates progression through early mitosis by inhibiting the anaphase promoting complex/cyclosome (APC). Binds to the APC activators CDC20 and FZR1/CDH1 to prevent APC activation. Can also bind directly to the APC to inhibit substrate-binding. {ECO:0000269|PubMed:11988738, ECO:0000269|PubMed:16921029}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|spindle assembly involved in female meiosis I|
|spindle assembly involved in female meiosis|
|regulation of mesenchymal stem cell migration|
|positive regulation of mesenchymal stem cell migration|
|ubiquitin ligase inhibitor activity|
|spindle assembly involved in meiosis|
|negative regulation of DNA endoreduplication|
|female meiosis I|
|anaphase-promoting complex binding|
|negative regulation of ubiquitin protein ligase activity|
|meiotic spindle|
|regulation of DNA endoreduplication|
|negative regulation of meiotic nuclear division|
|meiotic spindle organization|
|negative regulation of meiotic cell cycle|
|negative regulation of ubiquitin-protein transferase activity|
|negative regulation of cellular senescence|
|oocyte maturation|
|regulation of ubiquitin protein ligase activity|
|negative regulation of cell aging|
|negative regulation of mitotic metaphase/anaphase transition|
|negative regulation of metaphase/anaphase transition of cell cycle|
|negative regulation of DNA-dependent DNA replication|
|positive regulation of G2/M transition of mitotic cell cycle|
|negative regulation of mitotic sister chromatid separation|
|negative regulation of chromosome separation|
|regulation of transcription involved in G1/S transition of mitotic cell cycle|
|positive regulation of cell cycle G2/M phase transition|
|negative regulation of mitotic sister chromatid segregation|
|female meiotic nuclear division|
|regulation of meiotic nuclear division|
|negative regulation of sister chromatid segregation|
|microtubule polymerization|
|negative regulation of chromosome segregation|
|oocyte development|
|negative regulation of DNA replication|
|negative regulation of mitotic nuclear division|
|regulation of cellular senescence|
|oocyte differentiation|
|positive regulation of biomineral tissue development|
|positive regulation of biomineralization|
|regulation of cell aging|
|negative regulation of nuclear division|
|regulation of meiotic cell cycle|
|microtubule polymerization or depolymerization|
|regulation of ubiquitin-protein transferase activity|
|regulation of mitotic metaphase/anaphase transition|
|regulation of metaphase/anaphase transition of cell cycle|
|regulation of DNA-dependent DNA replication|
|negative regulation of reproductive process|
|regulation of mitotic sister chromatid separation|
|positive regulation of osteoblast differentiation|
|regulation of chromosome separation|
|regulation of mitotic sister chromatid segregation|
|negative regulation of protein ubiquitination|
|positive regulation of mitotic cell cycle phase transition|
|oogenesis|
|negative regulation of response to DNA damage stimulus|
|regulation of sister chromatid segregation|
|anaphase-promoting complex-dependent catabolic process|
|negative regulation of protein modification by small protein conjugation or removal|
|positive regulation of ossification|
|protein polymerization|
|regulation of biomineral tissue development|
|regulation of biomineralization|
|positive regulation of cell cycle phase transition|
|spindle assembly|
|regulation of chromosome segregation|
|regulation of DNA replication|
|meiosis I|
|meiosis I cell cycle process|
|regulation of osteoblast differentiation|
|spindle|
|G1/S transition of mitotic cell cycle|
|cell cycle G1/S phase transition|
|female gamete generation|
|negative regulation of chromosome organization|
|anatomical structure maturation|
|positive regulation of mitotic cell cycle|
|meiotic nuclear division|
|spindle organization|
|cell maturation|
|regulation of reproductive process|
|meiotic cell cycle process|
|regulation of mitotic nuclear division|
|regulation of ossification|
|regulation of nuclear division|
|regulation of G2/M transition of mitotic cell cycle|
|regulation of protein ubiquitination|
|regulation of cell cycle G2/M phase transition|
|negative regulation of mitotic cell cycle phase transition|
|regulation of response to DNA damage stimulus|
|meiotic cell cycle|
|regulation of protein modification by small protein conjugation or removal|
|negative regulation of cell cycle phase transition|
|developmental maturation|
|germ cell development|
|mitotic cell cycle phase transition|
|negative regulation of transferase activity|
|cell cycle phase transition|
|nuclear division|
|positive regulation of cell cycle process|
|vesicle organization|
|negative regulation of mitotic cell cycle|
|organelle fission|
|proteasome-mediated ubiquitin-dependent protein catabolic process|
|negative regulation of cell cycle process|
|regulation of chromosome organization|
|proteasomal protein catabolic process|
|cellular process involved in reproduction in multicellular organism|
|negative regulation of organelle organization|
|positive regulation of cell cycle|
|regulation of mitotic cell cycle phase transition|
|regulation of cell cycle phase transition|
|supramolecular fiber organization|
|protein kinase binding|
|microtubule cytoskeleton organization|
|cell division|
|positive regulation of cell migration|
|positive regulation of cell motility|
|ubiquitin-dependent protein catabolic process|
|modification-dependent protein catabolic process|
|positive regulation of cellular component movement|
|modification-dependent macromolecule catabolic process|
|positive regulation of locomotion|
|negative regulation of cell cycle|
|proteolysis involved in cellular protein catabolic process|
|negative regulation of protein modification process|
|mitotic cell cycle process|
|cellular protein catabolic process|
|regulation of mitotic cell cycle|
|developmental process involved in reproduction|
|microtubule-based process|
|protein catabolic process|
|mitotic cell cycle|
|protein ubiquitination|
|gamete generation|
|negative regulation of cellular component organization|
|regulation of cellular response to stress|
|regulation of cell cycle process|
|organelle assembly|
|protein modification by small protein conjugation|
|negative regulation of catalytic activity|
|multicellular organismal reproductive process|
|sexual reproduction|
|cellular protein-containing complex assembly|
|multicellular organism reproduction|
|regulation of cell migration|
|cellular macromolecule catabolic process|
|regulation of cell motility|
|positive regulation of cell population proliferation|
|negative regulation of developmental process|
|positive regulation of cell differentiation|
|regulation of transferase activity|
|regulation of locomotion|
|protein modification by small protein conjugation or removal|
|multi-organism reproductive process|
|regulation of cellular component movement|
|cell cycle process|
|negative regulation of cellular protein metabolic process|
|macromolecule catabolic process|
|organonitrogen compound catabolic process|
|negative regulation of protein metabolic process|
|cytoskeleton organization|
|negative regulation of molecular function|
|regulation of cell cycle|
|proteolysis|
|regulation of organelle organization|
|cell cycle|
|positive regulation of developmental process|
|negative regulation of cellular macromolecule biosynthetic process|
|reproductive process|
|reproduction|
|negative regulation of macromolecule biosynthetic process|
|regulation of response to stress|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
|protein-containing complex assembly|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|cell development|
|positive regulation of multicellular organismal process|
|organic substance catabolic process|
|cellular catabolic process|
|regulation of cell differentiation|
|regulation of protein modification process|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp256|HMS-I1 10μM R06 exp256]]|-1.94|
|[[:results:exp10|CCCP 0.1μM R00 exp10]]|1.72|
|[[:results:exp16|DABN 2μM R00 exp16]]|1.82|
|[[:results:exp156|UNC2400 2μM R03 exp156]]|1.87|
|[[:results:exp215|Colchicine 0.009μM R05 exp215]]|1.92|
|[[:results:exp99|NFN1 0.4μM R03 exp99]]|1.92|
|[[:results:exp310|2-Methoxyestradiol 0.55μM R07 exp310]]|1.95|
|[[:results:exp37|Wortmannin 0.5μM R00 exp37]]|1.95|
|[[:results:exp418|Tunicamycin 0.04μM R07 exp418]]|1.98|
|[[:results:exp348|Cyclosporin-A 3μM R07 exp348]]|2.22|
|[[:results:exp311|2-Methoxyestradiol 0.55 to 0.75μM  on day4 R07 exp311]]|2.5|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:z:znf655|ZNF655]]|0.476|
|[[:human genes:s:supt6h|SUPT6H]]|0.469|
|[[:human genes:t:twistnb|TWISTNB]]|0.469|
|[[:human genes:v:vasn|VASN]]|0.469|
|[[:human genes:p:psmd1|PSMD1]]|0.466|
|[[:human genes:m:myo1h|MYO1H]]|0.465|
|[[:human genes:m:med17|MED17]]|0.462|
|[[:human genes:r:rps2|RPS2]]|0.461|
|[[:human genes:z:znf106|ZNF106]]|0.459|
|[[:human genes:p:psmc2|PSMC2]]|0.453|
|[[:human genes:t:ticrr|TICRR]]|0.447|
|[[:human genes:p:prim1|PRIM1]]|0.441|
|[[:human genes:p:psma6|PSMA6]]|0.439|
|[[:human genes:g:gprin2|GPRIN2]]|0.437|
|[[:human genes:z:zfand5|ZFAND5]]|0.437|
|[[:human genes:s:scaf1|SCAF1]]|0.434|
|[[:human genes:s:sfpq|SFPQ]]|0.433|
|[[:human genes:s:stil|STIL]]|0.428|
|[[:human genes:r:rbbp5|RBBP5]]|0.426|
|[[:human genes:m:med12|MED12]]|0.425|
|[[:human genes:c:c14orf93|C14orf93]]|0.423|
|[[:human genes:a:atp6v0c|ATP6V0C]]|0.419|
|[[:human genes:c:chd4|CHD4]]|0.415|
|[[:human genes:r:ranbp2|RANBP2]]|0.415|
|[[:human genes:u:upf1|UPF1]]|0.414|
|[[:human genes:p:pcf11|PCF11]]|0.412|
|[[:human genes:m:med14|MED14]]|0.412|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.411|
|[[:human genes:t:top1mt|TOP1MT]]|0.41|
|[[:human genes:h:hap1|HAP1]]|0.409|
|[[:human genes:p:psmc4|PSMC4]]|0.408|
|[[:human genes:m:myb|MYB]]|0.405|
|[[:human genes:s:smg1|SMG1]]|0.405|
|[[:human genes:p:psmb4|PSMB4]]|0.405|
|[[:human genes:i:iscu|ISCU]]|0.404|
|[[:human genes:c:cox8a|COX8A]]|0.403|
|[[:human genes:d:dync1i2|DYNC1I2]]|0.403|
|[[:human genes:r:rpsa|RPSA]]|0.401|
|[[:human genes:o:orc6|ORC6]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 505/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|23/28|
|blood|14/28|
|bone|15/26|
|breast|24/33|
|central nervous system|36/56|
|cervix|3/4|
|colorectal|14/17|
|esophagus|10/13|
|fibroblast|0/1|
|gastric|13/16|
|kidney|14/21|
|liver|7/20|
|lung|50/75|
|lymphocyte|9/16|
|ovary|21/26|
|pancreas|17/24|
|peripheral nervous system|12/16|
|plasma cell|12/15|
|prostate|1/1|
|skin|18/24|
|soft tissue|8/9|
|thyroid|1/2|
|upper aerodigestive|13/22|
|urinary tract|23/29|
|uterus|4/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1638
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.2 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='FBXO5 Expression in NALM6 Cells: 6.2'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>