======= FBXO8 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: FBXO8
  * **<color #00a2e8>Official Name</color>**: F-box protein 8
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=26269|26269]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NRD0|Q9NRD0]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=FBXO8&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20FBXO8|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605649|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  May promote guanine-nucleotide exchange on an ARF. Promotes the activation of ARF through replacement of GDP with GTP (Potential). {ECO:0000305}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Sec7|
|F-box-like|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of ARF protein signal transduction|
|ARF guanyl-nucleotide exchange factor activity|
|ubiquitin ligase complex|
|regulation of Ras protein signal transduction|
|regulation of small GTPase mediated signal transduction|
|ubiquitin-dependent protein catabolic process|
|modification-dependent protein catabolic process|
|modification-dependent macromolecule catabolic process|
|proteolysis involved in cellular protein catabolic process|
|cellular protein catabolic process|
|protein catabolic process|
|cellular macromolecule catabolic process|
|macromolecule catabolic process|
|organonitrogen compound catabolic process|
|proteolysis|
|organic substance catabolic process|
|cellular catabolic process|
|regulation of intracellular signal transduction|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp131|L-74142 5μM R03 exp131]]|-2.04|
|[[:results:exp469|CFI-400945 25μM R08 exp469]]|-2.01|
|[[:results:exp46|HMS-I1 1μM R01 exp46]]|-2|
|[[:results:exp60|Vinblastine 0.002μM R01 exp60]]|-1.81|
|[[:results:exp429|Rapamycin 0.001μM R08 exp429]]|-1.76|
|[[:results:exp464|Calcipotriol 5μM R08 exp464]]|-1.73|
|[[:results:exp122|Golgicide-A 4μM R03 exp122]]|2.22|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17614
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.84 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='FBXO8 Expression in NALM6 Cells: 2.84'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>