======= FCER1G =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: FCER1G
  * **<color #00a2e8>Official Name</color>**: Fc fragment of IgE receptor Ig
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2207|2207]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P30273|P30273]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=FCER1G&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20FCER1G|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/147139|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The high affinity IgE receptor is a key molecule involved in allergic reactions. It is a tetramer composed of 1 alpha, 1 beta, and 2 gamma chains. The gamma chains are also subunits of other Fc receptors. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Associates with a variety of FcR alpha chains to form a functional signaling complex. Regulates several aspects of the immune response. The gamma subunit has a critical role in allowing the IgE Fc receptor to reach the cell surface. Also involved in collagen-mediated platelet activation and in neutrophil activation mediated by integrin. {ECO:0000269|PubMed:8611682}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|TCR zetazeta|
|ITAM|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|IgE receptor activity|
|positive regulation of type III hypersensitivity|
|negative regulation of mast cell apoptotic process|
|positive regulation of type I hypersensitivity|
|regulation of type III hypersensitivity|
|regulation of mast cell apoptotic process|
|serotonin secretion|
|serotonin production involved in inflammatory response|
|Fc-epsilon receptor I complex|
|serotonin secretion by platelet|
|positive regulation of mast cell cytokine production|
|regulation of type I hypersensitivity|
|serotonin secretion involved in inflammatory response|
|positive regulation of type IIa hypersensitivity|
|positive regulation of type II hypersensitivity|
|regulation of type II hypersensitivity|
|regulation of type IIa hypersensitivity|
|IgE binding|
|interleukin-3-mediated signaling pathway|
|regulation of mast cell cytokine production|
|positive regulation of hypersensitivity|
|serotonin transport|
|regulation of hypersensitivity|
|positive regulation of acute inflammatory response to antigenic stimulus|
|interleukin-2 production|
|IgG binding|
|positive regulation of inflammatory response to antigenic stimulus|
|regulation of acute inflammatory response to antigenic stimulus|
|positive regulation of mast cell degranulation|
|positive regulation of mast cell activation involved in immune response|
|production of molecular mediator involved in inflammatory response|
|negative regulation of myeloid cell apoptotic process|
|positive regulation of protein localization to cell surface|
|cellular response to low-density lipoprotein particle stimulus|
|positive regulation of myeloid leukocyte cytokine production involved in immune response|
|positive regulation of mast cell activation|
|monoamine transport|
|mast cell activation|
|positive regulation of interleukin-4 production|
|positive regulation of leukocyte degranulation|
|regulation of inflammatory response to antigenic stimulus|
|response to lipoprotein particle|
|regulation of interleukin-4 production|
|positive regulation of acute inflammatory response|
|cellular response to lipoprotein particle stimulus|
|regulation of myeloid cell apoptotic process|
|regulation of platelet activation|
|positive regulation of myeloid leukocyte mediated immunity|
|T cell differentiation involved in immune response|
|regulation of mast cell degranulation|
|regulation of mast cell activation involved in immune response|
|positive regulation of interleukin-10 production|
|positive regulation of B cell mediated immunity|
|positive regulation of immunoglobulin mediated immune response|
|regulation of protein localization to cell surface|
|osteoclast differentiation|
|regulation of acute inflammatory response|
|regulation of mast cell activation|
|negative regulation of leukocyte apoptotic process|
|regulation of leukocyte degranulation|
|regulation of B cell mediated immunity|
|regulation of immunoglobulin mediated immune response|
|regulation of interleukin-10 production|
|ammonium transport|
|positive regulation of regulated secretory pathway|
|positive regulation of cytokine production involved in immune response|
|regulation of myeloid leukocyte mediated immunity|
|ficolin-1-rich granule membrane|
|receptor internalization|
|T cell activation involved in immune response|
|exocytic process|
|positive regulation of phagocytosis|
|tertiary granule membrane|
|antigen processing and presentation of exogenous peptide antigen via MHC class I|
|regulation of blood coagulation|
|regulation of hemostasis|
|regulation of coagulation|
|regulation of leukocyte apoptotic process|
|neutrophil chemotaxis|
|regulation of cytokine production involved in immune response|
|positive regulation of tumor necrosis factor production|
|positive regulation of tumor necrosis factor superfamily cytokine production|
|positive regulation of exocytosis|
|granulocyte chemotaxis|
|neutrophil migration|
|integrin-mediated signaling pathway|
|positive regulation of interleukin-6 production|
|regulation of phagocytosis|
|positive regulation of production of molecular mediator of immune response|
|antigen processing and presentation of peptide antigen via MHC class I|
|antigen processing and presentation of exogenous peptide antigen via MHC class II|
|positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|antigen processing and presentation of peptide antigen via MHC class II|
|antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|
|granulocyte migration|
|receptor metabolic process|
|positive regulation of adaptive immune response|
|positive regulation of lymphocyte mediated immunity|
|lymphocyte activation involved in immune response|
|myeloid leukocyte differentiation|
|stimulatory C-type lectin receptor signaling pathway|
|innate immune response activating cell surface receptor signaling pathway|
|myeloid leukocyte migration|
|platelet degranulation|
|phagocytosis, engulfment|
|positive regulation of leukocyte mediated immunity|
|T cell differentiation|
|Fc receptor mediated stimulatory signaling pathway|
|platelet activation|
|regulation of wound healing|
|plasma membrane invagination|
|organic hydroxy compound transport|
|positive regulation of inflammatory response|
|Fc-gamma receptor signaling pathway|
|regulation of interleukin-6 production|
|regulation of production of molecular mediator of immune response|
|leukocyte chemotaxis|
|regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|membrane invagination|
|regulation of tumor necrosis factor production|
|regulation of lymphocyte mediated immunity|
|cytokine production|
|regulation of tumor necrosis factor superfamily cytokine production|
|regulation of adaptive immune response|
|regulation of regulated secretory pathway|
|regulation of response to wounding|
|Fc-epsilon receptor signaling pathway|
|antigen processing and presentation of exogenous peptide antigen|
|neurotransmitter transport|
|protein localization to plasma membrane|
|antigen processing and presentation of exogenous antigen|
|antigen processing and presentation of peptide antigen|
|regulation of leukocyte mediated immunity|
|immunoglobulin mediated immune response|
|positive regulation of intracellular transport|
|B cell mediated immunity|
|cell chemotaxis|
|antigen processing and presentation|
|positive regulation of immune effector process|
|myeloid cell differentiation|
|regulation of exocytosis|
|protein localization to cell periphery|
|innate immune response-activating signal transduction|
|T cell activation|
|lymphocyte differentiation|
|receptor-mediated endocytosis|
|Fc receptor signaling pathway|
|activation of innate immune response|
|lymphocyte mediated immunity|
|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|blood coagulation|
|coagulation|
|hemostasis|
|positive regulation of cellular protein localization|
|phagocytosis|
|defense response to bacterium|
|leukocyte differentiation|
|regulation of inflammatory response|
|protein homooligomerization|
|positive regulation of innate immune response|
|regulation of intracellular transport|
|positive regulation of response to biotic stimulus|
|leukocyte migration|
|lymphocyte activation|
|external side of plasma membrane|
|positive regulation of leukocyte activation|
|positive regulation of secretion by cell|
|positive regulation of cell activation|
|positive regulation of secretion|
|negative regulation of immune system process|
|positive regulation of cytokine production|
|immune response-activating cell surface receptor signaling pathway|
|regulation of innate immune response|
|regulation of immune effector process|
|positive regulation of defense response|
|wound healing|
|protein localization to membrane|
|immune response-regulating cell surface receptor signaling pathway|
|neutrophil degranulation|
|neutrophil activation involved in immune response|
|regulation of body fluid levels|
|inflammatory response|
|neutrophil mediated immunity|
|neutrophil activation|
|granulocyte activation|
|positive regulation of multi-organism process|
|leukocyte degranulation|
|myeloid leukocyte mediated immunity|
|protein complex oligomerization|
|regulation of response to biotic stimulus|
|myeloid cell activation involved in immune response|
|regulation of cellular protein localization|
|regulation of vesicle-mediated transport|
|chemotaxis|
|taxis|
|endocytosis|
|hemopoiesis|
|immune response-activating signal transduction|
|response to wounding|
|myeloid leukocyte activation|
|immune response-regulating signaling pathway|
|regulation of leukocyte activation|
|positive regulation of response to external stimulus|
|hematopoietic or lymphoid organ development|
|adaptive immune response|
|cell surface|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|activation of immune response|
|regulation of cell activation|
|immune system development|
|cytokine-mediated signaling pathway|
|import into cell|
|response to bacterium|
|regulation of cytokine production|
|regulated exocytosis|
|regulation of secretion by cell|
|regulation of defense response|
|innate immune response|
|leukocyte mediated immunity|
|regulation of multi-organism process|
|exocytosis|
|regulation of secretion|
|cation transport|
|membrane organization|
|positive regulation of immune response|
|protein homodimerization activity|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|regulation of cellular localization|
|leukocyte activation|
|defense response to other organism|
|cell migration|
|positive regulation of transport|
|negative regulation of cell death|
|response to organonitrogen compound|
|secretion by cell|
|cellular response to cytokine stimulus|
|regulation of protein localization|
|export from cell|
|cell activation|
|cell motility|
|localization of cell|
|response to nitrogen compound|
|immune effector process|
|regulation of response to external stimulus|
|response to cytokine|
|secretion|
|regulation of immune response|
|positive regulation of immune system process|
|response to other organism|
|response to external biotic stimulus|
|locomotion|
|response to biotic stimulus|
|defense response|
|ion transport|
|integral component of plasma membrane|
|response to endogenous stimulus|
|regulation of response to stress|
|regulation of apoptotic process|
|movement of cell or subcellular component|
|protein-containing complex assembly|
|regulation of programmed cell death|
|cellular protein localization|
|cellular macromolecule localization|
|regulation of immune system process|
|regulation of cell death|
|positive regulation of multicellular organismal process|
|nitrogen compound transport|
|protein-containing complex subunit organization|
|regulation of transport|
|immune response|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp131|L-74142 5μM R03 exp131]]|-1.98|
|[[:results:exp237|NN-Diethyl-meta-toluamide 100μM R05 exp237]]|-1.81|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|-1.71|
|[[:results:exp189|Temozolomide 200μM R04 exp189]]|1.8|
|[[:results:exp77|Prochlorperazine 5.2μM R02 exp77]]|1.86|
|[[:results:exp365|I-BRD9 4μM R07 exp365]]|1.91|
|[[:results:exp175|3-Bromopyruvate 7μM R04 exp175]]|1.95|
|[[:results:exp177|Apcin 25μM plus proTAME 2μM R04 exp177]]|1.95|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13819
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -0.91 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='FCER1G Expression in NALM6 Cells: -0.91'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>