======= FEN1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: FEN1
  * **<color #00a2e8>Official Name</color>**: flap structure-specific endonuclease 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2237|2237]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P39748|P39748]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=FEN1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20FEN1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600393|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double- stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA. {ECO:0000255|HAMAP-Rule:MF_03140, ECO:0000269|PubMed:10744741, ECO:0000269|PubMed:11986308, ECO:0000269|PubMed:18443037, ECO:0000269|PubMed:20729856, ECO:0000269|PubMed:7961795, ECO:0000269|PubMed:8621570}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|XPG N|
|XPG I|
|5 3 exonuc|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|double-stranded DNA exodeoxyribonuclease activity|
|flap endonuclease activity|
|DNA replication, removal of RNA primer|
|5-flap endonuclease activity|
|positive regulation of sister chromatid cohesion|
|5-3 exonuclease activity|
|UV protection|
|exonuclease activity|
|RNA-DNA hybrid ribonuclease activity|
|regulation of sister chromatid cohesion|
|telomere maintenance via semi-conservative replication|
|positive regulation of chromosome segregation|
|endonuclease activity|
|base-excision repair|
|nuclear DNA replication|
|cell cycle DNA replication|
|damaged DNA binding|
|manganese ion binding|
|regulation of sister chromatid segregation|
|RNA phosphodiester bond hydrolysis, endonucleolytic|
|double-strand break repair via homologous recombination|
|recombinational repair|
|telomere maintenance|
|telomere organization|
|regulation of chromosome segregation|
|double-stranded DNA binding|
|nuclear chromosome, telomeric region|
|memory|
|DNA-dependent DNA replication|
|response to UV|
|RNA phosphodiester bond hydrolysis|
|positive regulation of chromosome organization|
|double-strand break repair|
|DNA replication|
|magnesium ion binding|
|DNA recombination|
|RNA catabolic process|
|learning or memory|
|positive regulation of cell cycle process|
|cognition|
|nucleic acid phosphodiester bond hydrolysis|
|response to light stimulus|
|anatomical structure homeostasis|
|regulation of chromosome organization|
|nucleobase-containing compound catabolic process|
|positive regulation of cell cycle|
|heterocycle catabolic process|
|cellular nitrogen compound catabolic process|
|response to radiation|
|aromatic compound catabolic process|
|organic cyclic compound catabolic process|
|DNA repair|
|behavior|
|protein-containing complex|
|positive regulation of organelle organization|
|DNA metabolic process|
|regulation of cell cycle process|
|cellular response to DNA damage stimulus|
|nucleolus|
|cellular homeostasis|
|cellular macromolecule catabolic process|
|cell cycle process|
|macromolecule catabolic process|
|chromosome organization|
|response to abiotic stimulus|
|regulation of cell cycle|
|positive regulation of cellular component organization|
|mitochondrion|
|regulation of organelle organization|
|cell cycle|
|nervous system process|
|DNA binding|
|homeostatic process|
|RNA metabolic process|
|cellular response to stress|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|organic substance catabolic process|
|cellular catabolic process|
|system process|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp528|TGF-beta1 44ng/ml R08 exp528]]|-2.25|
|[[:results:exp150|SGC0649 7μM R03 exp150]]|-2.16|
|[[:results:exp494|Isoniazid 100μM R08 exp494]]|-1.73|
|[[:results:exp144|PFI-3 10μM R03 exp144]]|-1.73|
|[[:results:exp299|Talazoparib 0.006μM R06 exp299]]|-1.71|
|[[:results:exp487|Hinokiflavone 12μM R08 exp487]]|1.8|
|[[:results:exp269|Bisphenol A 100μM R06 exp269]]|1.83|
|[[:results:exp48|Mubritinib 0.2μM R01 exp48]]|2.35|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:a:adsl|ADSL]]|0.521|
|[[:human genes:r:rpp21|RPP21]]|0.477|
|[[:human genes:p:ppcs|PPCS]]|0.475|
|[[:human genes:g:gemin8|GEMIN8]]|0.459|
|[[:human genes:r:rft1|RFT1]]|0.455|
|[[:human genes:g:gtf3c4|GTF3C4]]|0.449|
|[[:human genes:p:ptar1|PTAR1]]|0.449|
|[[:human genes:t:ten1|TEN1]]|0.448|
|[[:human genes:r:rabggtb|RABGGTB]]|0.446|
|[[:human genes:a:alg1|ALG1]]|0.445|
|[[:human genes:t:thg1l|THG1L]]|0.443|
|[[:human genes:u:utp23|UTP23]]|0.442|
|[[:human genes:f:fh|FH]]|0.44|
|[[:human genes:g:gmppb|GMPPB]]|0.438|
|[[:human genes:d:dolk|DOLK]]|0.434|
|[[:human genes:d:ddx20|DDX20]]|0.428|
|[[:human genes:p:ppp6c|PPP6C]]|0.424|
|[[:human genes:r:rpia|RPIA]]|0.424|
|[[:human genes:g:gemin7|GEMIN7]]|0.419|
|[[:human genes:c:ccdc115|CCDC115]]|0.418|
|[[:human genes:g:gemin6|GEMIN6]]|0.415|
|[[:human genes:p:ppp4c|PPP4C]]|0.41|
|[[:human genes:c:c15orf41|C15orf41]]|0.403|
|[[:human genes:d:dpagt1|DPAGT1]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 495/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|20/28|
|blood|22/28|
|bone|23/26|
|breast|24/33|
|central nervous system|42/56|
|cervix|2/4|
|colorectal|9/17|
|esophagus|9/13|
|fibroblast|1/1|
|gastric|10/16|
|kidney|14/21|
|liver|7/20|
|lung|45/75|
|lymphocyte|14/16|
|ovary|17/26|
|pancreas|17/24|
|peripheral nervous system|7/16|
|plasma cell|6/15|
|prostate|0/1|
|skin|19/24|
|soft tissue|6/9|
|thyroid|1/2|
|upper aerodigestive|16/22|
|urinary tract|24/29|
|uterus|2/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 83
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.82 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='FEN1 Expression in NALM6 Cells: 7.82'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>