======= FERMT2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: FERMT2
  * **<color #00a2e8>Official Name</color>**: fermitin family member 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10979|10979]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96AC1|Q96AC1]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=FERMT2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20FERMT2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607746|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Scaffolding protein that enhances integrin activation mediated by TLN1 and/or TLN2, but activates integrins only weakly by itself. Binds to membranes enriched in phosphoinositides. Enhances integrin-mediated cell adhesion onto the extracellular matrix and cell spreading; this requires both its ability to interact with integrins and with phospholipid membranes. Required for the assembly of focal adhesions. Participates in the connection between extracellular matrix adhesion sites and the actin cytoskeleton and also in the orchestration of actin assembly and cell shape modulation. Recruits FBLIM1 to focal adhesions. Plays a role in the TGFB1 and integrin signaling pathways. Stabilizes active CTNNB1 and plays a role in the regulation of transcription mediated by CTNNB1 and TCF7L2/TCF4 and in Wnt signaling. {ECO:0000269|PubMed:12679033, ECO:0000269|PubMed:18458155, ECO:0000269|PubMed:21325030, ECO:0000269|PubMed:22030399, ECO:0000269|PubMed:22078565, ECO:0000269|PubMed:22699938}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PH|
|FERM M|
|FERM N|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|integrin activation|
|I band|
|lamellipodium membrane|
|focal adhesion assembly|
|cell-substrate adherens junction assembly|
|adherens junction assembly|
|phosphatidylinositol-3,4,5-trisphosphate binding|
|cell-substrate junction assembly|
|substrate adhesion-dependent cell spreading|
|extrinsic component of cytoplasmic side of plasma membrane|
|stress fiber|
|adherens junction organization|
|integrin-mediated signaling pathway|
|transforming growth factor beta receptor signaling pathway|
|cell-matrix adhesion|
|cell cortex|
|regulation of cell shape|
|cellular response to transforming growth factor beta stimulus|
|response to transforming growth factor beta|
|cell junction assembly|
|cell-substrate adhesion|
|transmembrane receptor protein serine/threonine kinase signaling pathway|
|actin filament binding|
|cell junction organization|
|Wnt signaling pathway|
|cell-cell signaling by wnt|
|focal adhesion|
|cell surface receptor signaling pathway involved in cell-cell signaling|
|protein localization to membrane|
|regulation of cell morphogenesis|
|cellular response to growth factor stimulus|
|response to growth factor|
|cell morphogenesis involved in differentiation|
|cell surface|
|enzyme linked receptor protein signaling pathway|
|cell morphogenesis|
|cellular component morphogenesis|
|cell adhesion|
|biological adhesion|
|regulation of anatomical structure morphogenesis|
|cell-cell signaling|
|cellular response to endogenous stimulus|
|response to endogenous stimulus|
|protein-containing complex assembly|
|cellular protein localization|
|cellular macromolecule localization|
|cell development|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp471|Cholesterol 0.003 to 0.006 to 0.1μM on day2 then day6 R08 exp471]]|1.73|
|[[:results:exp152|SGC2043 10μM R03 exp152]]|2.15|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 191/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|1/1|
|bile duct|7/28|
|blood|0/28|
|bone|2/26|
|breast|5/33|
|central nervous system|26/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|1/1|
|gastric|3/16|
|kidney|14/21|
|liver|8/20|
|lung|19/75|
|lymphocyte|0/16|
|ovary|13/26|
|pancreas|1/24|
|peripheral nervous system|4/16|
|plasma cell|1/15|
|prostate|0/1|
|skin|17/24|
|soft tissue|4/9|
|thyroid|1/2|
|upper aerodigestive|1/22|
|urinary tract|6/29|
|uterus|2/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6193
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.71 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='FERMT2 Expression in NALM6 Cells: 3.71'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>