======= FFAR3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: FFAR3
  * **<color #00a2e8>Official Name</color>**: free fatty acid receptor 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2865|2865]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O14843|O14843]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=FFAR3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20FFAR3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603821|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  G protein-coupled receptor that is activated by a major product of dietary fiber digestion, the short chain fatty acids (SCFAs), and that plays a role in the regulation of whole-body energy homeostasis and in intestinal immunity. In omnivorous mammals, the short chain fatty acids acetate, propionate and butyrate are produced primarily by the gut microbiome that metabolizes dietary fibers. SCFAs serve as a source of energy but also act as signaling molecules. That G protein-coupled receptor is probably coupled to the pertussis toxin-sensitive, G(i/o)-alpha family of G proteins. Its activation results in the formation of inositol 1,4,5-trisphosphate, the mobilization of intracellular calcium, the phosphorylation of the MAPK3/ERK1 and MAPK1/ERK2 kinases and the inhibition of intracellular cAMP accumulation (PubMed:12711604). Activated by SCFAs and by beta-hydroxybutyrate, a ketone body produced by the liver upon starvation, it inhibits N-type calcium channels and modulates the activity of sympathetic neurons through a signaling cascade involving the beta and gamma subunits of its coupled G protein, phospholipase C and MAP kinases. Thereby, it may regulate energy expenditure through the control of the sympathetic nervous system that controls for instance heart rate. Upon activation by SCFAs accumulating in the intestine, it may also signal to the brain via neural circuits which in turn would regulate intestinal gluconeogenesis. May also control the production of hormones involved in whole-body energy homeostasis. May for instance, regulate blood pressure through renin secretion. May also regulate secretion of the PYY peptide by enteroendocrine cells and control gut motility, intestinal transit rate, and the harvesting of energy from SCFAs produced by gut microbiota. May also indirectly regulate the production of LEP/Leptin, a hormone acting on the CNS to inhibit food intake, in response to the presence of short-chain fatty acids in the intestine. Finally, may also play a role in glucose homeostasis. Besides its role in energy homeostasis, may play a role in intestinal immunity. May mediate the activation of the inflammatory and immune response by SCFAs in the gut, regulating the rapid production of chemokines and cytokines by intestinal epithelial cells. Among SCFAs, the fatty acids containing less than 6 carbons, the most potent activators are probably propionate, butyrate and pentanoate while acetate is a poor activator (PubMed:12496283, PubMed:12711604). {ECO:0000269|PubMed:12496283, ECO:0000269|PubMed:12711604, ECO:0000269|PubMed:18801738, ECO:0000269|PubMed:23066016}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|7tm 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of acute inflammatory response to non-antigenic stimulus|
|regulation of acute inflammatory response to non-antigenic stimulus|
|regulation of norepinephrine secretion|
|regulation of hormone biosynthetic process|
|positive regulation of acute inflammatory response|
|mucosal immune response|
|organ or tissue specific immune response|
|regulation of hormone metabolic process|
|regulation of acute inflammatory response|
|negative regulation of blood pressure|
|positive regulation of cytokine production involved in immune response|
|cellular response to fatty acid|
|positive regulation of chemokine production|
|regulation of catecholamine secretion|
|regulation of insulin receptor signaling pathway|
|regulation of cellular response to insulin stimulus|
|regulation of chemokine production|
|response to fatty acid|
|adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway|
|regulation of cytokine production involved in immune response|
|regulation of amine transport|
|positive regulation of production of molecular mediator of immune response|
|positive regulation of inflammatory response|
|regulation of production of molecular mediator of immune response|
|lipid binding|
|regulation of blood pressure|
|adenylate cyclase-modulating G protein-coupled receptor signaling pathway|
|cellular response to acid chemical|
|regulation of peptide hormone secretion|
|positive regulation of immune effector process|
|G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger|
|regulation of hormone secretion|
|regulation of inflammatory response|
|response to acid chemical|
|blood circulation|
|circulatory system process|
|positive regulation of cytokine production|
|regulation of immune effector process|
|positive regulation of defense response|
|regulation of peptide secretion|
|inflammatory response|
|cellular response to lipid|
|regulation of hormone levels|
|positive regulation of response to external stimulus|
|regulation of cytokine production|
|G protein-coupled receptor activity|
|regulation of peptide transport|
|regulation of secretion by cell|
|regulation of defense response|
|regulation of secretion|
|response to lipid|
|positive regulation of immune response|
|cellular response to oxygen-containing compound|
|regulation of response to external stimulus|
|positive regulation of immune system process|
|regulation of immune response|
|G protein-coupled receptor signaling pathway|
|defense response|
|integral component of plasma membrane|
|regulation of response to stress|
|response to oxygen-containing compound|
|regulation of immune system process|
|positive regulation of multicellular organismal process|
|regulation of transport|
|immune response|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4442
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -7.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='FFAR3 Expression in NALM6 Cells: -7.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>