======= FGA =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: FGA
  * **<color #00a2e8>Official Name</color>**: fibrinogen alpha chain
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2243|2243]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P02671|P02671]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=FGA&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20FGA|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/134820|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes the alpha subunit of the coagulation factor fibrinogen, which is a component of the blood clot. Following vascular injury, the encoded preproprotein is proteolytically processed by thrombin during the conversion of fibrinogen to fibrin. Mutations in this gene lead to several disorders, including dysfibrinogenemia, hypofibrinogenemia, afibrinogenemia and renal amyloidosis. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that undergoes proteolytic processing. [provided by RefSeq, Jan 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Cleaved by the protease thrombin to yield monomers which, together with fibrinogen beta (FGB) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets via an ITGB3- dependent pathway. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the immune response via both innate and T-cell mediated pathways. {ECO:0000250|UniProtKB:E9PV24}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Fibrinogen C|
|Fibrinogen aC|
|Fib alpha|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|blood coagulation, common pathway|
|induction of bacterial agglutination|
|fibrinogen complex|
|plasminogen activation|
|platelet alpha granule|
|positive regulation of heterotypic cell-cell adhesion|
|fibrinolysis|
|protein activation cascade|
|regulation of heterotypic cell-cell adhesion|
|blood coagulation, fibrin clot formation|
|negative regulation of endothelial cell apoptotic process|
|positive regulation of vasoconstriction|
|negative regulation of extrinsic apoptotic signaling pathway via death domain receptors|
|positive regulation of substrate adhesion-dependent cell spreading|
|antibacterial humoral response|
|zymogen activation|
|negative regulation of epithelial cell apoptotic process|
|platelet aggregation|
|regulation of endothelial cell apoptotic process|
|negative regulation of blood coagulation|
|negative regulation of hemostasis|
|negative regulation of coagulation|
|regulation of substrate adhesion-dependent cell spreading|
|extracellular vesicle|
|regulation of extrinsic apoptotic signaling pathway via death domain receptors|
|regulation of vasoconstriction|
|cell adhesion molecule binding|
|homotypic cell-cell adhesion|
|platelet alpha granule lumen|
|positive regulation of blood circulation|
|negative regulation of wound healing|
|regulation of epithelial cell apoptotic process|
|regulation of blood coagulation|
|regulation of hemostasis|
|regulation of coagulation|
|negative regulation of response to wounding|
|protein polymerization|
|positive regulation of exocytosis|
|positive regulation of peptide hormone secretion|
|toll-like receptor signaling pathway|
|negative regulation of extrinsic apoptotic signaling pathway|
|antimicrobial humoral response|
|positive regulation of cell-substrate adhesion|
|cell-matrix adhesion|
|positive regulation of hormone secretion|
|pattern recognition receptor signaling pathway|
|platelet degranulation|
|extracellular matrix structural constituent|
|platelet activation|
|regulation of wound healing|
|regulation of tube diameter|
|regulation of blood vessel diameter|
|regulation of tube size|
|blood microparticle|
|response to calcium ion|
|regulation of extrinsic apoptotic signaling pathway|
|positive regulation of cell morphogenesis involved in differentiation|
|protein processing|
|regulation of response to wounding|
|vascular process in circulatory system|
|cell-substrate adhesion|
|structural molecule activity|
|regulation of peptide hormone secretion|
|positive regulation of ERK1 and ERK2 cascade|
|regulation of cell-substrate adhesion|
|regulation of exocytosis|
|negative regulation of apoptotic signaling pathway|
|protein maturation|
|innate immune response-activating signal transduction|
|positive regulation of cell-cell adhesion|
|activation of innate immune response|
|regulation of hormone secretion|
|positive regulation of protein secretion|
|regulation of blood circulation|
|positive regulation of peptide secretion|
|regulation of ERK1 and ERK2 cascade|
|blood coagulation|
|coagulation|
|hemostasis|
|endoplasmic reticulum lumen|
|regulation of cell morphogenesis involved in differentiation|
|defense response to bacterium|
|signaling receptor binding|
|extracellular matrix organization|
|positive regulation of innate immune response|
|humoral immune response|
|positive regulation of response to biotic stimulus|
|post-translational protein modification|
|collagen-containing extracellular matrix|
|negative regulation of response to external stimulus|
|response to metal ion|
|extracellular structure organization|
|blood circulation|
|external side of plasma membrane|
|circulatory system process|
|regulation of cell-cell adhesion|
|regulation of apoptotic signaling pathway|
|positive regulation of secretion by cell|
|positive regulation of cell adhesion|
|positive regulation of protein transport|
|positive regulation of secretion|
|regulation of innate immune response|
|positive regulation of establishment of protein localization|
|regulation of protein secretion|
|positive regulation of defense response|
|wound healing|
|regulation of cell morphogenesis|
|regulation of peptide secretion|
|regulation of body fluid levels|
|cell-cell adhesion|
|positive regulation of multi-organism process|
|regulation of anatomical structure size|
|regulation of response to biotic stimulus|
|regulation of hormone levels|
|response to inorganic substance|
|positive regulation of cell development|
|positive regulation of MAPK cascade|
|regulation of vesicle-mediated transport|
|immune response-activating signal transduction|
|response to wounding|
|regulation of system process|
|immune response-regulating signaling pathway|
|positive regulation of response to external stimulus|
|adaptive immune response|
|cell surface|
|activation of immune response|
|regulation of cell adhesion|
|response to bacterium|
|regulated exocytosis|
|regulation of protein transport|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|regulation of MAPK cascade|
|regulation of defense response|
|innate immune response|
|regulation of multi-organism process|
|exocytosis|
|regulation of secretion|
|cellular protein-containing complex assembly|
|positive regulation of immune response|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|cell adhesion|
|regulation of cell development|
|biological adhesion|
|defense response to other organism|
|positive regulation of cell differentiation|
|positive regulation of transport|
|negative regulation of cell death|
|secretion by cell|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|regulation of protein localization|
|export from cell|
|positive regulation of phosphorylation|
|regulation of anatomical structure morphogenesis|
|cell activation|
|regulation of response to external stimulus|
|secretion|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|positive regulation of immune system process|
|regulation of immune response|
|negative regulation of multicellular organismal process|
|positive regulation of cellular component organization|
|positive regulation of protein modification process|
|negative regulation of signal transduction|
|proteolysis|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of developmental process|
|regulation of protein phosphorylation|
|regulation of response to stress|
|regulation of apoptotic process|
|protein-containing complex assembly|
|regulation of programmed cell death|
|regulation of phosphorylation|
|extracellular space|
|positive regulation of cellular protein metabolic process|
|negative regulation of response to stimulus|
|regulation of immune system process|
|positive regulation of signal transduction|
|regulation of cell death|
|positive regulation of protein metabolic process|
|positive regulation of multicellular organismal process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|protein-containing complex subunit organization|
|regulation of transport|
|immune response|
|extracellular region|
|vesicle-mediated transport|
|system process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp13|Chloramphenicol 20μM R00 exp13]]|1.77|
|[[:results:exp14|Cycloheximide 0.02μM R00 exp14]]|1.79|
|[[:results:exp215|Colchicine 0.009μM R05 exp215]]|1.95|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11355
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -7.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='FGA Expression in NALM6 Cells: -7.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>