======= FGF1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: FGF1
  * **<color #00a2e8>Official Name</color>**: fibroblast growth factor 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2246|2246]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P05230|P05230]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=FGF1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20FGF1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/131220|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrin ITGAV:ITGB3. Its binding to integrin, subsequent ternary complex formation with integrin and FGFR1, and the recruitment of PTPN11 to the complex are essential for FGF1 signaling. Induces the phosphorylation and activation of FGFR1, FRS2, MAPK3/ERK1, MAPK1/ERK2 and AKT1 (PubMed:18441324, PubMed:20422052). Can induce angiogenesis (PubMed:23469107). {ECO:0000269|PubMed:16597617, ECO:0000269|PubMed:18441324, ECO:0000269|PubMed:20145243, ECO:0000269|PubMed:20422052, ECO:0000269|PubMed:23469107, ECO:0000269|PubMed:8663044}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|FGF|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|branch elongation involved in ureteric bud branching|
|positive regulation of cholesterol biosynthetic process|
|positive regulation of sterol biosynthetic process|
|ureteric bud elongation|
|regulation of endothelial tube morphogenesis|
|positive regulation of cholesterol metabolic process|
|regulation of cell chemotaxis to fibroblast growth factor|
|regulation of endothelial cell chemotaxis to fibroblast growth factor|
|S100 protein binding|
|organ induction|
|branch elongation of an epithelium|
|positive regulation of steroid biosynthetic process|
|fibroblast growth factor receptor binding|
|regulation of endothelial cell chemotaxis|
|positive regulation of alcohol biosynthetic process|
|axis elongation|
|developmental induction|
|positive regulation of steroid metabolic process|
|activation of protein kinase B activity|
|regulation of animal organ formation|
|positive regulation of sprouting angiogenesis|
|Hsp70 protein binding|
|regulation of sterol biosynthetic process|
|regulation of cholesterol biosynthetic process|
|branching involved in ureteric bud morphogenesis|
|ureteric bud morphogenesis|
|mesonephric tubule morphogenesis|
|regulation of cholesterol metabolic process|
|nephron tubule morphogenesis|
|nephron epithelium morphogenesis|
|nephron morphogenesis|
|renal tubule morphogenesis|
|regulation of sprouting angiogenesis|
|cellular response to heat|
|regulation of alcohol biosynthetic process|
|nephron tubule development|
|positive regulation of lipid biosynthetic process|
|renal tubule development|
|fibroblast growth factor receptor signaling pathway|
|positive regulation of animal organ morphogenesis|
|kidney morphogenesis|
|ureteric bud development|
|mesonephric epithelium development|
|mesonephric tubule development|
|positive regulation of cell division|
|regulation of steroid biosynthetic process|
|mesonephros development|
|nephron epithelium development|
|positive regulation of endothelial cell migration|
|cellular response to fibroblast growth factor stimulus|
|response to heat|
|developmental growth involved in morphogenesis|
|regulation of steroid metabolic process|
|response to fibroblast growth factor|
|nephron development|
|kidney epithelium development|
|branching morphogenesis of an epithelial tube|
|integrin binding|
|cell cortex|
|positive regulation of small molecule metabolic process|
|positive regulation of epithelial cell migration|
|positive regulation of lipid metabolic process|
|activation of MAPK activity|
|regulation of endothelial cell migration|
|morphogenesis of a branching epithelium|
|growth factor activity|
|positive regulation of angiogenesis|
|positive regulation of protein kinase B signaling|
|regulation of cell division|
|morphogenesis of a branching structure|
|lung development|
|heparin binding|
|respiratory tube development|
|response to temperature stimulus|
|regulation of morphogenesis of an epithelium|
|positive regulation of vasculature development|
|regulation of lipid biosynthetic process|
|positive regulation of epithelial cell proliferation|
|respiratory system development|
|regulation of chemotaxis|
|regulation of protein kinase B signaling|
|regulation of epithelial cell migration|
|extracellular matrix|
|regulation of animal organ morphogenesis|
|positive regulation of MAP kinase activity|
|kidney development|
|regulation of cellular response to growth factor stimulus|
|renal system development|
|regulation of angiogenesis|
|epithelial tube morphogenesis|
|angiogenesis|
|urogenital system development|
|regulation of vasculature development|
|activation of protein kinase activity|
|regulation of epithelial cell proliferation|
|positive regulation of protein serine/threonine kinase activity|
|regulation of MAP kinase activity|
|MAPK cascade|
|developmental growth|
|growth|
|signal transduction by protein phosphorylation|
|regulation of lipid metabolic process|
|blood vessel morphogenesis|
|regulation of small molecule metabolic process|
|morphogenesis of an epithelium|
|blood vessel development|
|cellular response to growth factor stimulus|
|positive regulation of cell migration|
|vasculature development|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|regulation of protein serine/threonine kinase activity|
|cardiovascular system development|
|positive regulation of cell motility|
|response to growth factor|
|positive regulation of protein kinase activity|
|positive regulation of cellular component movement|
|positive regulation of MAPK cascade|
|positive regulation of locomotion|
|cell population proliferation|
|tissue morphogenesis|
|positive regulation of kinase activity|
|tube morphogenesis|
|positive regulation of transferase activity|
|enzyme linked receptor protein signaling pathway|
|regulation of MAPK cascade|
|regulation of protein kinase activity|
|tube development|
|regulation of cell migration|
|nucleolus|
|circulatory system development|
|regulation of kinase activity|
|anatomical structure formation involved in morphogenesis|
|regulation of cell motility|
|positive regulation of cell population proliferation|
|animal organ morphogenesis|
|protein phosphorylation|
|regulation of transferase activity|
|regulation of locomotion|
|regulation of cellular component movement|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|positive regulation of phosphorylation|
|regulation of anatomical structure morphogenesis|
|regulation of response to external stimulus|
|epithelium development|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|response to abiotic stimulus|
|positive regulation of transcription by RNA polymerase II|
|cellular response to endogenous stimulus|
|positive regulation of protein modification process|
|phosphorylation|
|positive regulation of developmental process|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|response to endogenous stimulus|
|positive regulation of transcription, DNA-templated|
|regulation of phosphorylation|
|extracellular space|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|positive regulation of signal transduction|
|intracellular signal transduction|
|cellular response to stress|
|positive regulation of protein metabolic process|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|tissue development|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|extracellular region|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp275|Citral 75μM R06 exp275]]|1.76|
|[[:results:exp189|Temozolomide 200μM R04 exp189]]|1.89|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15890
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -1.6 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='FGF1 Expression in NALM6 Cells: -1.6'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>