======= FGF10 =======
== Gene Information ==
* **Official Symbol**: FGF10
* **Official Name**: fibroblast growth factor 10
* **Aliases and Previous Symbols**: N/A
* **Entrez ID**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2255|2255]]
* **UniProt**: [[https://www.uniprot.org/uniprot/O15520|O15520]]
* **Interactions**: [[https://thebiogrid.org/search.php?search=FGF10&organism=9606|BioGRID]]
* **PubMed articles**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20FGF10|Open PubMed]]
* **OMIM**: [[https://omim.org/entry/602115|Open OMIM]]
== Function Summary ==
* **Entrez Summary**: The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein exhibits mitogenic activity for keratinizing epidermal cells, but essentially no activity for fibroblasts, which is similar to the biological activity of FGF7. Studies of the mouse homolog of suggested that this gene is required for embryonic epidermal morphogenesis including brain development, lung morphogenesis, and initiation of lim bud formation. This gene is also implicated to be a primary factor in the process of wound healing. [provided by RefSeq, Jul 2008].
* **UniProt Summary**: Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. Required for normal branching morphogenesis. May play a role in wound healing. {ECO:0000269|PubMed:16597617}.
|FGF|
|semicircular canal fusion|
|lung proximal/distal axis specification|
|submandibular salivary gland formation|
|bronchiole morphogenesis|
|lung pattern specification process|
|positive regulation of hair follicle cell proliferation|
|mesenchymal-epithelial cell signaling involved in lung development|
|urothelial cell proliferation|
|positive regulation of urothelial cell proliferation|
|regulation of hair follicle cell proliferation|
|regulation of urothelial cell proliferation|
|cell-cell signaling involved in lung development|
|semicircular canal formation|
|branch elongation involved in salivary gland morphogenesis|
|mammary gland bud formation|
|fibroblast growth factor receptor signaling pathway involved in mammary gland specification|
|tear secretion|
|mesenchymal cell differentiation involved in lung development|
|positive regulation of white fat cell proliferation|
|secretion by lung epithelial cell involved in lung growth|
|mammary gland bud morphogenesis|
|proximal/distal axis specification|
|type 2 fibroblast growth factor receptor binding|
|bud outgrowth involved in lung branching|
|embryonic genitalia morphogenesis|
|female genitalia morphogenesis|
|mammary gland specification|
|regulation of white fat cell proliferation|
|bronchiole development|
|Harderian gland development|
|regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling|
|male genitalia morphogenesis|
|positive regulation of fat cell proliferation|
|male anatomical structure morphogenesis|
|prostatic bud formation|
|type II pneumocyte differentiation|
|epithelial cell proliferation involved in salivary gland morphogenesis|
|lung growth|
|mammary gland formation|
|regulation of saliva secretion|
|morphogenesis of an epithelial bud|
|lacrimal gland development|
|semicircular canal morphogenesis|
|bud elongation involved in lung branching|
|otic vesicle formation|
|positive regulation of epithelial cell proliferation involved in wound healing|
|lung saccule development|
|mesenchymal-epithelial cell signaling|
|lung secretory cell differentiation|
|semicircular canal development|
|otic vesicle morphogenesis|
|regulation of branching involved in salivary gland morphogenesis|
|lateral sprouting from an epithelium|
|regulation of fat cell proliferation|
|limb bud formation|
|radial glial cell differentiation|
|positive regulation of keratinocyte migration|
|positive regulation of keratinocyte proliferation|
|white fat cell differentiation|
|regulation of keratinocyte migration|
|otic vesicle development|
|genitalia morphogenesis|
|induction of positive chemotaxis|
|muscle cell fate commitment|
|organ induction|
|positive regulation of vascular endothelial growth factor receptor signaling pathway|
|specification of animal organ identity|
|branch elongation of an epithelium|
|female genitalia development|
|branching involved in salivary gland morphogenesis|
|embryonic digestive tract morphogenesis|
|morphogenesis of an epithelial fold|
|secretion by tissue|
|lung epithelial cell differentiation|
|lung cell differentiation|
|fibroblast growth factor receptor binding|
|thyroid gland development|
|prostate gland epithelium morphogenesis|
|male genitalia development|
|negative regulation of cell cycle arrest|
|prostate gland morphogenesis|
|positive regulation of positive chemotaxis|
|hair follicle morphogenesis|
|regulation of activin receptor signaling pathway|
|protein localization to cell surface|
|regulation of positive chemotaxis|
|epithelial tube branching involved in lung morphogenesis|
|metanephros morphogenesis|
|developmental induction|
|axis elongation|
|ERK1 and ERK2 cascade|
|establishment of mitotic spindle orientation|
|epidermis morphogenesis|
|salivary gland morphogenesis|
|lung epithelium development|
|proximal/distal pattern formation|
|mammary gland duct morphogenesis|
|smooth muscle cell differentiation|
|regulation of vascular endothelial growth factor receptor signaling pathway|
|blood vessel remodeling|
|salivary gland development|
|spleen development|
|establishment of mitotic spindle localization|
|regulation of keratinocyte proliferation|
|embryonic digestive tract development|
|animal organ formation|
|negative regulation of extrinsic apoptotic signaling pathway in absence of ligand|
|establishment of spindle orientation|
|negative regulation of signal transduction in absence of ligand|
|positive regulation of G1/S transition of mitotic cell cycle|
|chemoattractant activity|
|positive regulation of DNA replication|
|regulation of animal organ formation|
|embryonic camera-type eye development|
|regulation of digestive system process|
|lung alveolus development|
|prostate gland development|
|pituitary gland development|
|exocrine system development|
|establishment of spindle localization|
|mammary gland morphogenesis|
|lung morphogenesis|
|thymus development|
|regulation of extrinsic apoptotic signaling pathway in absence of ligand|
|genitalia development|
|positive regulation of cell cycle G1/S phase transition|
|spindle localization|
|positive chemotaxis|
|digestive tract morphogenesis|
|positive regulation of fibroblast proliferation|
|positive regulation of Notch signaling pathway|
|positive regulation of ATPase activity|
|regulation of morphogenesis of a branching structure|
|mammary gland epithelium development|
|embryonic pattern specification|
|tissue regeneration|
|positive regulation of Ras protein signal transduction|
|somatic stem cell population maintenance|
|actin cytoskeleton reorganization|
|positive regulation of DNA repair|
|positive regulation of small GTPase mediated signal transduction|
|hair follicle development|
|pancreas development|
|skin epidermis development|
|body fluid secretion|
|hair cycle process|
|molting cycle process|
|diencephalon development|
|positive regulation of mitotic cell cycle phase transition|
|regulation of smoothened signaling pathway|
|fibroblast growth factor receptor signaling pathway|
|regulation of ATPase activity|
|positive regulation of animal organ morphogenesis|
|regulation of fibroblast proliferation|
|odontogenesis of dentin-containing tooth|
|metanephros development|
|kidney morphogenesis|
|axis specification|
|epithelial cell proliferation|
|mesonephros development|
|tube closure|
|hair cycle|
|molting cycle|
|positive regulation of cell cycle phase transition|
|organ growth|
|inner ear morphogenesis|
|gland morphogenesis|
|positive regulation of response to DNA damage stimulus|
|tissue remodeling|
|negative regulation of extrinsic apoptotic signaling pathway|
|regulation of Notch signaling pathway|
|microtubule cytoskeleton organization involved in mitosis|
|fat cell differentiation|
|female sex differentiation|
|regulation of cell cycle arrest|
|regulation of DNA replication|
|cellular response to fibroblast growth factor stimulus|
|developmental growth involved in morphogenesis|
|response to fibroblast growth factor|
|determination of left/right symmetry|
|ear morphogenesis|
|establishment of cell polarity|
|odontogenesis|
|endocrine system development|
|determination of bilateral symmetry|
|regulation of DNA repair|
|specification of symmetry|
|mammary gland development|
|positive regulation of lymphocyte proliferation|
|branching morphogenesis of an epithelial tube|
|digestive tract development|
|positive regulation of mononuclear cell proliferation|
|epithelial tube formation|
|stem cell population maintenance|
|positive regulation of chemotaxis|
|response to estradiol|
|positive regulation of leukocyte proliferation|
|maintenance of cell number|
|positive regulation of epithelial cell migration|
|digestive system development|
|positive regulation of canonical Wnt signaling pathway|
|morphogenesis of embryonic epithelium|
|tube formation|
|appendage morphogenesis|
|limb morphogenesis|
|regulation of G1/S transition of mitotic cell cycle|
|positive regulation of mitotic cell cycle|
|regulation of extrinsic apoptotic signaling pathway|
|activation of MAPK activity|
|mesenchymal cell differentiation|
|male sex differentiation|
|regeneration|
|morphogenesis of a branching epithelium|
|growth factor activity|
|positive regulation of protein kinase B signaling|
|regulation of cell cycle G1/S phase transition|
|morphogenesis of a branching structure|
|lung development|
|glial cell differentiation|
|heparin binding|
|respiratory tube development|
|positive regulation of Wnt signaling pathway|
|appendage development|
|regulation of morphogenesis of an epithelium|
|limb development|
|positive regulation of epithelial cell proliferation|
|positive regulation of peptidyl-tyrosine phosphorylation|
|positive regulation of DNA metabolic process|
|inner ear development|
|respiratory system development|
|establishment or maintenance of cell polarity|
|regulation of lymphocyte proliferation|
|regulation of mononuclear cell proliferation|
|positive regulation of ERK1 and ERK2 cascade|
|regulation of chemotaxis|
|gliogenesis|
|regulation of response to DNA damage stimulus|
|regulation of epithelial cell migration|
|regulation of protein kinase B signaling|
|ear development|
|mesenchyme development|
|regulation of leukocyte proliferation|
|negative regulation of apoptotic signaling pathway|
|regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|regulation of Ras protein signal transduction|
|muscle cell differentiation|
|cell fate commitment|
|regulation of peptidyl-tyrosine phosphorylation|
|sensory organ morphogenesis|
|regulation of animal organ morphogenesis|
|positive regulation of MAP kinase activity|
|sex differentiation|
|kidney development|
|regulation of cellular response to growth factor stimulus|
|regulation of canonical Wnt signaling pathway|
|renal system development|
|positive regulation of cell cycle process|
|embryonic organ morphogenesis|
|regulation of ERK1 and ERK2 cascade|
|epithelial tube morphogenesis|
|camera-type eye development|
|response to lipopolysaccharide|
|angiogenesis|
|urogenital system development|
|negative regulation of cell cycle process|
|response to molecule of bacterial origin|
|activation of protein kinase activity|
|regionalization|
|regulation of epithelial cell proliferation|
|positive regulation of protein serine/threonine kinase activity|
|regulation of MAP kinase activity|
|regulation of small GTPase mediated signal transduction|
|regulation of DNA metabolic process|
|eye development|
|positive regulation of lymphocyte activation|
|visual system development|
|regulation of Wnt signaling pathway|
|establishment of organelle localization|
|collagen-containing extracellular matrix|
|sensory system development|
|MAPK cascade|
|positive regulation of cell cycle|
|skin development|
|forebrain development|
|developmental growth|
|growth|
|signal transduction by protein phosphorylation|
|regulation of apoptotic signaling pathway|
|positive regulation of leukocyte activation|
|blood vessel morphogenesis|
|gland development|
|regulation of mitotic cell cycle phase transition|
|epidermis development|
|positive regulation of cell activation|
|reproductive structure development|
|reproductive system development|
|morphogenesis of an epithelium|
|embryonic organ development|
|pattern specification process|
|regulation of cell cycle phase transition|
|muscle structure development|
|microtubule cytoskeleton organization|
|wound healing|
|blood vessel development|
|actin cytoskeleton organization|
|regulation of body fluid levels|
|positive regulation of cell migration|
|cellular response to growth factor stimulus|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|vasculature development|
|regulation of lymphocyte activation|
|regulation of protein serine/threonine kinase activity|
|cardiovascular system development|
|positive regulation of cell motility|
|response to growth factor|
|positive regulation of protein kinase activity|
|positive regulation of cellular component movement|
|positive regulation of MAPK cascade|
|sensory organ development|
|chemotaxis|
|taxis|
|positive regulation of locomotion|
|cell population proliferation|
|tissue morphogenesis|
|embryonic morphogenesis|
|actin filament-based process|
|response to wounding|
|negative regulation of cell cycle|
|positive regulation of kinase activity|
|organelle localization|
|regulation of system process|
|mitotic cell cycle process|
|regulation of leukocyte activation|
|positive regulation of response to external stimulus|
|hematopoietic or lymphoid organ development|
|cell surface|
|regulation of mitotic cell cycle|
|regulation of cell activation|
|immune system development|
|tube morphogenesis|
|positive regulation of transferase activity|
|developmental process involved in reproduction|
|microtubule-based process|
|negative regulation of cell population proliferation|
|epithelial cell differentiation|
|mitotic cell cycle|
|response to bacterium|
|negative regulation of cell differentiation|
|enzyme linked receptor protein signaling pathway|
|regulation of cellular response to stress|
|brain development|
|regulation of cell cycle process|
|regulation of MAPK cascade|
|positive regulation of hydrolase activity|
|head development|
|regulation of protein kinase activity|
|regulation of secretion|
|tube development|
|regulation of cell migration|
|response to lipid|
|circulatory system development|
|regulation of kinase activity|
|negative regulation of apoptotic process|
|anatomical structure formation involved in morphogenesis|
|negative regulation of programmed cell death|
|response to hormone|
|regulation of cell motility|
|positive regulation of cell population proliferation|
|response to organic cyclic compound|
|negative regulation of developmental process|
|animal organ morphogenesis|
|protein phosphorylation|
|regulation of transferase activity|
|embryo development|
|central nervous system development|
|regulation of locomotion|
|regulation of cellular component movement|
|negative regulation of cell death|
|cell cycle process|
|secretion by cell|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|export from cell|
|positive regulation of phosphorylation|
|regulation of anatomical structure morphogenesis|
|regulation of response to external stimulus|
|cytoskeleton organization|
|epithelium development|
|cell-cell signaling|
|secretion|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|positive regulation of immune system process|
|regulation of cell cycle|
|positive regulation of transcription by RNA polymerase II|
|cellular response to endogenous stimulus|
|positive regulation of protein modification process|
|negative regulation of signal transduction|
|regulation of hydrolase activity|
|phosphorylation|
|response to other organism|
|response to external biotic stimulus|
|locomotion|
|response to biotic stimulus|
|cell cycle|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of developmental process|
|reproductive process|
|reproduction|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|response to endogenous stimulus|
|regulation of response to stress|
|positive regulation of transcription, DNA-templated|
|regulation of apoptotic process|
|response to oxygen-containing compound|
|regulation of programmed cell death|
|cellular protein localization|
|regulation of phosphorylation|
|extracellular space|
|cellular macromolecule localization|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|neurogenesis|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|positive regulation of signal transduction|
|regulation of immune system process|
|regulation of cell death|
|intracellular signal transduction|
|positive regulation of protein metabolic process|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|tissue development|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|establishment of localization in cell|
|regulation of protein modification process|
|regulation of transport|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|extracellular region|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
\\
=== CRISPR Data ===
^Screen^Score^
|[[:results:exp259|6-Thio-2-deoxyguanosine 2μM R06 exp259]]|-2.08|
|[[:results:exp492|iCRT14 30μM R08 exp492]]|-1.97|
|[[:results:exp375|Lenalidomide 20μM R07 exp375]]|-1.81|
|[[:results:exp24|Nocodazole 0.2μM R00 exp24]]|-1.8|
|[[:results:exp460|BML-284 0.09μM R08 exp460]]|-1.72|
|[[:results:exp294|Nutlin-3A 1.6μM R06 exp294]]|-1.72|
|[[:results:exp233|EPZ-5676 30μM R05 exp233]]|-1.71|
|[[:results:exp301|VER-155008 3.9μM R06 exp301]]|1.73|
|[[:results:exp287|HMS-I2 5μM R06 exp287]]|2|
No correlation found to any other genes in chemogenomics.
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|1/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
== Essentiality in NALM6 ==
* **Essentiality Rank**: 8863
* **Expression level (log2 read counts)**: -2.43
{{:chemogenomics:nalm6 dist.png?nolink |}}