======= FGF13 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: FGF13
  * **<color #00a2e8>Official Name</color>**: fibroblast growth factor 13
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2258|2258]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q92913|Q92913]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=FGF13&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20FGF13|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/300070|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Microtubule-binding protein which directly binds tubulin and is involved in both polymerization and stabilization of microtubules. Through its action on microtubules, may participate to the refinement of axons by negatively regulating axonal and leading processes branching. Plays a crucial role in neuron polarization and migration in the cerebral cortex and the hippocampus. {ECO:0000269|PubMed:15282281}. May also play a role in MAPK signaling. {ECO:0000269|PubMed:15282281}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|FGF|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|establishment or maintenance of neuroblast polarity|
|establishment of neuroblast polarity|
|asymmetric neuroblast division|
|regulation of cardiac muscle cell action potential involved in regulation of contraction|
|negative regulation of collateral sprouting|
|asymmetric stem cell division|
|neuronal stem cell division|
|neuroblast division|
|asymmetric cell division|
|regulation of collateral sprouting|
|somatic stem cell division|
|negative regulation of microtubule depolymerization|
|protein kinase activator activity|
|regulation of cardiac muscle cell action potential|
|regulation of microtubule depolymerization|
|neuroblast proliferation|
|microtubule polymerization|
|stem cell division|
|sodium channel regulator activity|
|negative regulation of microtubule polymerization or depolymerization|
|regulation of cardiac muscle cell contraction|
|beta-tubulin binding|
|regulation of actin filament-based movement|
|cerebral cortex cell migration|
|intercalated disc|
|regulation of action potential|
|microtubule polymerization or depolymerization|
|stem cell proliferation|
|lateral plasma membrane|
|telencephalon cell migration|
|forebrain cell migration|
|negative regulation of protein depolymerization|
|negative regulation of axonogenesis|
|negative regulation of protein complex disassembly|
|filopodium|
|neural precursor cell proliferation|
|regulation of cardiac muscle contraction|
|regulation of microtubule polymerization or depolymerization|
|hippocampus development|
|regulation of protein depolymerization|
|protein polymerization|
|regulation of striated muscle contraction|
|negative regulation of cell morphogenesis involved in differentiation|
|negative regulation of developmental growth|
|limbic system development|
|regulation of extent of cell growth|
|regulation of protein complex disassembly|
|cerebral cortex development|
|memory|
|establishment of cell polarity|
|neuron migration|
|ion channel binding|
|growth cone|
|negative regulation of supramolecular fiber organization|
|negative regulation of cytoskeleton organization|
|learning|
|sodium ion transport|
|negative regulation of neuron projection development|
|regulation of muscle contraction|
|growth factor activity|
|pallium development|
|regulation of cell size|
|negative regulation of cell projection organization|
|negative regulation of cell growth|
|protein localization to plasma membrane|
|regulation of axonogenesis|
|regulation of microtubule cytoskeleton organization|
|establishment or maintenance of cell polarity|
|regulation of microtubule-based process|
|negative regulation of neuron differentiation|
|protein localization to cell periphery|
|regulation of muscle system process|
|microtubule binding|
|negative regulation of growth|
|regulation of heart contraction|
|cell fate commitment|
|telencephalon development|
|learning or memory|
|regulation of blood circulation|
|negative regulation of neurogenesis|
|axon|
|cognition|
|regulation of cell morphogenesis involved in differentiation|
|negative regulation of nervous system development|
|microtubule|
|neuron projection|
|activation of protein kinase activity|
|regulation of developmental growth|
|negative regulation of cell development|
|regulation of supramolecular fiber organization|
|MAPK cascade|
|negative regulation of organelle organization|
|regulation of cellular component size|
|forebrain development|
|regulation of actin filament-based process|
|signal transduction by protein phosphorylation|
|monovalent inorganic cation transport|
|regulation of cell growth|
|dendrite|
|regulation of membrane potential|
|supramolecular fiber organization|
|microtubule cytoskeleton organization|
|protein localization to membrane|
|regulation of cell morphogenesis|
|cell division|
|regulation of neuron projection development|
|regulation of anatomical structure size|
|positive regulation of protein kinase activity|
|regulation of cytoskeleton organization|
|cell population proliferation|
|behavior|
|positive regulation of kinase activity|
|regulation of system process|
|metal ion transport|
|positive regulation of transferase activity|
|regulation of neuron differentiation|
|microtubule-based process|
|regulation of growth|
|regulation of plasma membrane bounded cell projection organization|
|negative regulation of cellular component organization|
|regulation of cell projection organization|
|negative regulation of cell differentiation|
|brain development|
|head development|
|regulation of protein kinase activity|
|regulation of neurogenesis|
|cation transport|
|cellular protein-containing complex assembly|
|nucleolus|
|regulation of kinase activity|
|regulation of nervous system development|
|regulation of cell development|
|negative regulation of developmental process|
|cell migration|
|protein phosphorylation|
|regulation of transferase activity|
|central nervous system development|
|regulation of cellular component movement|
|positive regulation of protein phosphorylation|
|positive regulation of phosphorylation|
|regulation of anatomical structure morphogenesis|
|localization of cell|
|cell motility|
|cytoskeleton organization|
|cell-cell signaling|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|negative regulation of multicellular organismal process|
|positive regulation of protein modification process|
|phosphorylation|
|regulation of organelle organization|
|locomotion|
|ion transport|
|nervous system process|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|generation of neurons|
|movement of cell or subcellular component|
|protein-containing complex assembly|
|cellular protein localization|
|regulation of phosphorylation|
|cellular macromolecule localization|
|positive regulation of cellular protein metabolic process|
|neurogenesis|
|intracellular signal transduction|
|positive regulation of protein metabolic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|regulation of protein modification process|
|protein-containing complex subunit organization|
|extracellular region|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp48|Mubritinib 0.2μM R01 exp48]]|1.94|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:b:brd2|BRD2]]|0.421|
|[[:human genes:t:tspy2|TSPY2]]|0.412|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/694
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/26|
|bone|0/26|
|breast|0/30|
|central nervous system|0/49|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/11|
|fibroblast|0/1|
|gastric|0/14|
|kidney|0/18|
|liver|0/19|
|lung|0/72|
|lymphocyte|0/16|
|ovary|0/25|
|pancreas|0/22|
|peripheral nervous system|0/15|
|plasma cell|0/12|
|prostate|0/1|
|skin|0/20|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/28|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17500
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.23 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='FGF13 Expression in NALM6 Cells: 5.23'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>