======= FGF20 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: FGF20
  * **<color #00a2e8>Official Name</color>**: fibroblast growth factor 20
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=26281|26281]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NP95|Q9NP95]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=FGF20&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20FGF20|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605558|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a member of the fibroblast growth factor family. The fibroblast growth factors possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene product is a secreted neurotrophic factor but lacks a typical signal peptide. It is expressed in normal brain, particularly the cerebellum, and may regulate central nervous system development and function. Homodimerization of this protein was shown to regulate its receptor binding activity and concentration gradient in the extracellular matrix. Genetic variations of this gene have been associated with Parkinson disease susceptibility. [provided by RefSeq, Oct 2009]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Neurotrophic factor that regulates central nervous development and function. {ECO:0000269|PubMed:16597617}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|FGF|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|receptor-receptor interaction|
|positive regulation of dopaminergic neuron differentiation|
|regulation of dopaminergic neuron differentiation|
|heparan sulfate proteoglycan binding|
|fibroblast growth factor receptor binding|
|regulation of cardiac muscle cell proliferation|
|regulation of dopamine secretion|
|inner ear receptor cell differentiation|
|mechanoreceptor differentiation|
|regulation of cardiac muscle tissue growth|
|regulation of catecholamine secretion|
|regulation of heart growth|
|regulation of cardiac muscle tissue development|
|fibroblast growth factor receptor signaling pathway|
|regulation of organ growth|
|regulation of amine transport|
|regulation of response to drug|
|cellular response to fibroblast growth factor stimulus|
|response to fibroblast growth factor|
|regulation of striated muscle tissue development|
|regulation of muscle tissue development|
|regulation of muscle organ development|
|negative regulation of neuron apoptotic process|
|growth factor activity|
|positive regulation of protein kinase B signaling|
|inner ear development|
|regulation of neuron apoptotic process|
|negative regulation of neuron death|
|positive regulation of ERK1 and ERK2 cascade|
|regulation of protein kinase B signaling|
|ear development|
|regulation of ERK1 and ERK2 cascade|
|regulation of neuron death|
|regulation of developmental growth|
|signaling receptor binding|
|positive regulation of neuron differentiation|
|MAPK cascade|
|signal transduction by protein phosphorylation|
|positive regulation of neurogenesis|
|cellular response to growth factor stimulus|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|response to growth factor|
|positive regulation of nervous system development|
|positive regulation of cell development|
|positive regulation of MAPK cascade|
|sensory organ development|
|regulation of neuron differentiation|
|regulation of growth|
|regulation of ion transport|
|enzyme linked receptor protein signaling pathway|
|regulation of secretion by cell|
|regulation of MAPK cascade|
|regulation of secretion|
|regulation of neurogenesis|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|positive regulation of cell population proliferation|
|regulation of nervous system development|
|regulation of cell development|
|positive regulation of cell differentiation|
|protein phosphorylation|
|negative regulation of cell death|
|neuron differentiation|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|positive regulation of phosphorylation|
|cell-cell signaling|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|cellular response to endogenous stimulus|
|positive regulation of protein modification process|
|phosphorylation|
|positive regulation of developmental process|
|regulation of protein phosphorylation|
|response to endogenous stimulus|
|generation of neurons|
|regulation of apoptotic process|
|regulation of programmed cell death|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|neurogenesis|
|positive regulation of signal transduction|
|regulation of cell death|
|intracellular signal transduction|
|positive regulation of protein metabolic process|
|positive regulation of multicellular organismal process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|regulation of transport|
|extracellular region|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|1.83|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 18041
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -5.28 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='FGF20 Expression in NALM6 Cells: -5.28'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>