======= FGF7 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: FGF7
  * **<color #00a2e8>Official Name</color>**: fibroblast growth factor 7
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2252|2252]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P21781|P21781]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=FGF7&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20FGF7|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/148180|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein is a potent epithelial cell-specific growth factor, whose mitogenic activity is predominantly exhibited in keratinocytes but not in fibroblasts and endothelial cells. Studies of mouse and rat homologs of this gene implicated roles in morphogenesis of epithelium, reepithelialization of wounds, hair development and early lung organogenesis. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. Required for normal branching morphogenesis. Growth factor active on keratinocytes. Possible major paracrine effector of normal epithelial cell proliferation. {ECO:0000269|PubMed:16597617, ECO:0000269|PubMed:8663044}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|FGF|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|secretion by lung epithelial cell involved in lung growth|
|regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling|
|positive regulation of epithelial cell proliferation involved in lung morphogenesis|
|lung growth|
|regulation of epithelial cell proliferation involved in lung morphogenesis|
|mesenchymal-epithelial cell signaling|
|regulation of branching involved in salivary gland morphogenesis|
|positive regulation of keratinocyte migration|
|positive regulation of keratinocyte proliferation|
|regulation of keratinocyte migration|
|mesenchymal cell proliferation|
|branching involved in salivary gland morphogenesis|
|fibroblast growth factor receptor binding|
|hair follicle morphogenesis|
|protein localization to cell surface|
|epidermis morphogenesis|
|salivary gland morphogenesis|
|salivary gland development|
|regulation of keratinocyte proliferation|
|chemoattractant activity|
|exocrine system development|
|positive chemotaxis|
|regulation of morphogenesis of a branching structure|
|actin cytoskeleton reorganization|
|hair follicle development|
|skin epidermis development|
|hair cycle process|
|molting cycle process|
|fibroblast growth factor receptor signaling pathway|
|positive regulation of animal organ morphogenesis|
|positive regulation of cell division|
|molting cycle|
|hair cycle|
|organ growth|
|gland morphogenesis|
|cellular response to fibroblast growth factor stimulus|
|response to fibroblast growth factor|
|positive regulation of epithelial cell migration|
|morphogenesis of a branching epithelium|
|growth factor activity|
|positive regulation of protein kinase B signaling|
|morphogenesis of a branching structure|
|regulation of cell division|
|lung development|
|heparin binding|
|respiratory tube development|
|regulation of morphogenesis of an epithelium|
|positive regulation of epithelial cell proliferation|
|positive regulation of peptidyl-tyrosine phosphorylation|
|respiratory system development|
|regulation of epithelial cell migration|
|regulation of protein kinase B signaling|
|regulation of peptidyl-tyrosine phosphorylation|
|regulation of animal organ morphogenesis|
|regulation of epithelial cell proliferation|
|MAPK cascade|
|skin development|
|developmental growth|
|growth|
|signal transduction by protein phosphorylation|
|gland development|
|epidermis development|
|morphogenesis of an epithelium|
|actin cytoskeleton organization|
|cellular response to growth factor stimulus|
|positive regulation of cell migration|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|positive regulation of cell motility|
|response to growth factor|
|positive regulation of cellular component movement|
|chemotaxis|
|taxis|
|positive regulation of locomotion|
|cell population proliferation|
|tissue morphogenesis|
|actin filament-based process|
|response to wounding|
|enzyme linked receptor protein signaling pathway|
|tube development|
|regulation of cell migration|
|regulation of cell motility|
|positive regulation of cell population proliferation|
|animal organ morphogenesis|
|protein phosphorylation|
|regulation of locomotion|
|Golgi apparatus|
|regulation of cellular component movement|
|secretion by cell|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|export from cell|
|positive regulation of phosphorylation|
|regulation of anatomical structure morphogenesis|
|cytoskeleton organization|
|epithelium development|
|cell-cell signaling|
|secretion|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|cellular response to endogenous stimulus|
|positive regulation of protein modification process|
|phosphorylation|
|locomotion|
|positive regulation of developmental process|
|regulation of protein phosphorylation|
|response to endogenous stimulus|
|positive regulation of transcription, DNA-templated|
|cellular protein localization|
|regulation of phosphorylation|
|cellular macromolecule localization|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|positive regulation of signal transduction|
|intracellular signal transduction|
|positive regulation of protein metabolic process|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|tissue development|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|extracellular region|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp270|Campthothecin 0.001μM R06 exp270]]|-1.77|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10623
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.99 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='FGF7 Expression in NALM6 Cells: 2.99'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>