======= FGFBP3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: FGFBP3
  * **<color #00a2e8>Official Name</color>**: fibroblast growth factor binding protein 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=143282|143282]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8TAT2|Q8TAT2]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=FGFBP3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20FGFBP3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/620879|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Heparin-binding protein which binds to FGF2, prevents binding of FGF2 to heparin and probably inhibits immobilization of FGF2 on extracellular matrix glycosaminoglycans, allowing its release and subsequent activation of FGFR signaling which leads to increased vascular permeability. {ECO:0000269|PubMed:18669637}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|FGF-BP1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of fibroblast growth factor receptor signaling pathway|
|positive regulation of vascular permeability|
|fibroblast growth factor binding|
|regulation of fibroblast growth factor receptor signaling pathway|
|regulation of vascular permeability|
|vascular process in circulatory system|
|heparin binding|
|regulation of cellular response to growth factor stimulus|
|collagen-containing extracellular matrix|
|blood circulation|
|circulatory system process|
|cell-cell signaling|
|positive regulation of signal transduction|
|positive regulation of cell communication|
|positive regulation of signaling|
|extracellular region|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp50|Nicotinamide 2000μM R01 exp50]]|-1.87|
|[[:results:exp286|HMS-I2 1μM R06 exp286]]|-1.74|
|[[:results:exp438|NN-Diethyl-meta-toluamide 500μM R08 exp438]]|1.84|
|[[:results:exp199|Etoposide 0.3μM R05 exp199]]|2.21|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15025
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.89 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='FGFBP3 Expression in NALM6 Cells: 3.89'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>