======= FIG4 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: FIG4
  * **<color #00a2e8>Official Name</color>**: FIG4 phosphoinositide 5-phosphatase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9896|9896]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q92562|Q92562]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=FIG4&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20FIG4|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/609390|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene belongs to the SAC domain-containing protein gene family. The SAC domain, approximately 400 amino acids in length and consisting of seven conserved motifs, has been shown to possess phosphoinositide phosphatase activity. The yeast homolog, Sac1p, is involved in the regulation of various phosphoinositides, and affects diverse cellular functions such as actin cytoskeleton organization, Golgi function, and maintenance of vacuole morphology. Membrane-bound phosphoinositides function as signaling molecules and play a key role in vesicle trafficking in eukaryotic cells. Mutations in this gene have been associated with Charcot-Marie-Tooth disease, type 4J. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). In vitro, hydrolyzes all three D5-phosphorylated polyphosphoinositide substrates in the order PtdIns(4,5)P2 > PtdIns(3,5)P2 > PtdIns(3,4,5)P3. Plays a role in the biogenesis of endosome carrier vesicles (ECV) / multivesicular bodies (MVB) transport intermediates from early endosomes. {ECO:0000269|PubMed:17556371}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Syja N|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity|
|phosphatidylinositol-4-phosphate phosphatase activity|
|negative regulation of myelination|
|phosphatidylinositol-3-phosphatase activity|
|phosphatidylinositol-3-phosphate biosynthetic process|
|myelin assembly|
|negative regulation of nervous system process|
|regulation of myelination|
|lipid droplet|
|pigmentation|
|cellular component assembly involved in morphogenesis|
|myelination|
|axon ensheathment|
|ensheathment of neurons|
|phosphatidylinositol biosynthetic process|
|recycling endosome|
|late endosome membrane|
|vacuole organization|
|regulation of nervous system process|
|early endosome membrane|
|phosphatidylinositol metabolic process|
|locomotory behavior|
|glycerophospholipid biosynthetic process|
|endosome membrane|
|glycerolipid biosynthetic process|
|phospholipid biosynthetic process|
|positive regulation of neuron projection development|
|glycerophospholipid metabolic process|
|dephosphorylation|
|negative regulation of nervous system development|
|positive regulation of neuron differentiation|
|phospholipid metabolic process|
|glycerolipid metabolic process|
|positive regulation of cell projection organization|
|positive regulation of neurogenesis|
|regulation of neuron projection development|
|organophosphate biosynthetic process|
|positive regulation of nervous system development|
|positive regulation of cell development|
|behavior|
|lipid biosynthetic process|
|regulation of system process|
|Golgi membrane|
|regulation of neuron differentiation|
|intracellular membrane-bounded organelle|
|regulation of plasma membrane bounded cell projection organization|
|regulation of cell projection organization|
|neuron development|
|regulation of neurogenesis|
|cellular component morphogenesis|
|organophosphate metabolic process|
|anatomical structure formation involved in morphogenesis|
|regulation of nervous system development|
|regulation of cell development|
|negative regulation of developmental process|
|cellular lipid metabolic process|
|positive regulation of cell differentiation|
|neuron differentiation|
|endoplasmic reticulum|
|negative regulation of multicellular organismal process|
|positive regulation of cellular component organization|
|lipid metabolic process|
|positive regulation of developmental process|
|generation of neurons|
|neurogenesis|
|cell development|
|positive regulation of multicellular organismal process|
|regulation of cell differentiation|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp131|L-74142 5μM R03 exp131]]|-2.49|
|[[:results:exp169|BH1 1μM R04 exp169]]|-1.98|
|[[:results:exp233|EPZ-5676 30μM R05 exp233]]|-1.82|
|[[:results:exp504|MK2206 4μM R08 exp504]]|-1.74|
|[[:results:exp246|UM0011500 10μM R05 exp246]]|2.07|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6201
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.3 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='FIG4 Expression in NALM6 Cells: 3.3'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>