======= FIS1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: FIS1
  * **<color #00a2e8>Official Name</color>**: fission, mitochondrial 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=51024|51024]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y3D6|Q9Y3D6]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=FIS1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20FIS1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/609003|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in the fragmentation of the mitochondrial network and its perinuclear clustering. Plays a minor role in the recruitment and association of the fission mediator dynamin- related protein 1 (DNM1L) to the mitochondrial surface and mitochondrial fission. Can induce cytochrome c release from the mitochondrion to the cytosol, ultimately leading to apoptosis. Also mediates peroxisomal fission. {ECO:0000269|PubMed:12783892, ECO:0000269|PubMed:12861026, ECO:0000269|PubMed:14996942, ECO:0000269|PubMed:16107562, ECO:0000269|PubMed:16118244, ECO:0000269|PubMed:23283981, ECO:0000269|PubMed:23530241}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|response to thapsigargin|
|cellular response to thapsigargin|
|response to flavonoid|
|response to hypobaric hypoxia|
|response to fluoride|
|negative regulation of endoplasmic reticulum calcium ion concentration|
|peroxisome fission|
|mitochondrial fragmentation involved in apoptotic process|
|positive regulation of mitochondrial calcium ion concentration|
|positive regulation of mitochondrial fission|
|integral component of peroxisomal membrane|
|mitochondrial fusion|
|mitochondrial fission|
|integral component of mitochondrial outer membrane|
|mitochondrion morphogenesis|
|release of cytochrome c from mitochondria|
|endoplasmic reticulum calcium ion homeostasis|
|regulation of mitochondrial fission|
|calcium-mediated signaling using intracellular calcium source|
|response to muscle activity|
|mitochondrial calcium ion homeostasis|
|positive regulation of protein targeting to membrane|
|regulation of protein targeting to membrane|
|mitochondrion disassembly|
|autophagy of mitochondrion|
|positive regulation of neuron apoptotic process|
|positive regulation of intrinsic apoptotic signaling pathway|
|protein targeting to mitochondrion|
|apoptotic mitochondrial changes|
|organelle disassembly|
|response to activity|
|cellular response to glucose stimulus|
|establishment of protein localization to mitochondrion|
|cellular response to hexose stimulus|
|cellular response to monosaccharide stimulus|
|protein localization to mitochondrion|
|peroxisome organization|
|cellular response to carbohydrate stimulus|
|regulation of protein targeting|
|cellular glucose homeostasis|
|positive regulation of neuron death|
|organelle fusion|
|peroxisome|
|positive regulation of mitochondrion organization|
|positive regulation of protein localization to membrane|
|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|response to glucose|
|response to hexose|
|calcium-mediated signaling|
|response to monosaccharide|
|positive regulation of cysteine-type endopeptidase activity|
|positive regulation of intracellular protein transport|
|regulation of intrinsic apoptotic signaling pathway|
|mitochondrial outer membrane|
|response to carbohydrate|
|positive regulation of endopeptidase activity|
|positive regulation of apoptotic signaling pathway|
|regulation of mitochondrion organization|
|glucose homeostasis|
|carbohydrate homeostasis|
|regulation of protein localization to membrane|
|positive regulation of peptidase activity|
|regulation of neuron apoptotic process|
|positive regulation of intracellular transport|
|cellular response to toxic substance|
|regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|mitochondrial transport|
|regulation of intracellular protein transport|
|regulation of cysteine-type endopeptidase activity|
|process utilizing autophagic mechanism|
|autophagy|
|protein-containing complex binding|
|positive regulation of cytosolic calcium ion concentration|
|apoptotic signaling pathway|
|regulation of neuron death|
|organelle fission|
|positive regulation of cellular protein localization|
|cellular response to peptide|
|regulation of cytosolic calcium ion concentration|
|second-messenger-mediated signaling|
|protein homooligomerization|
|response to hypoxia|
|response to acid chemical|
|regulation of intracellular transport|
|response to decreased oxygen levels|
|positive regulation of proteolysis|
|protein targeting|
|response to oxygen levels|
|regulation of apoptotic signaling pathway|
|cellular component disassembly|
|regulation of endopeptidase activity|
|positive regulation of protein transport|
|establishment of protein localization to organelle|
|cellular calcium ion homeostasis|
|mitochondrion organization|
|regulation of peptidase activity|
|calcium ion homeostasis|
|positive regulation of establishment of protein localization|
|cellular divalent inorganic cation homeostasis|
|response to peptide|
|divalent inorganic cation homeostasis|
|response to nutrient levels|
|response to toxic substance|
|cell part morphogenesis|
|protein complex oligomerization|
|cellular response to lipid|
|response to extracellular stimulus|
|response to inorganic substance|
|regulation of cellular protein localization|
|cellular response to organic cyclic compound|
|cellular metal ion homeostasis|
|protein-containing complex|
|cellular response to organonitrogen compound|
|positive regulation of organelle organization|
|metal ion homeostasis|
|cellular cation homeostasis|
|positive regulation of apoptotic process|
|cellular ion homeostasis|
|positive regulation of programmed cell death|
|cellular response to nitrogen compound|
|positive regulation of cell death|
|regulation of protein transport|
|cation homeostasis|
|inorganic ion homeostasis|
|regulation of proteolysis|
|protein localization to organelle|
|regulation of peptide transport|
|cellular chemical homeostasis|
|regulation of establishment of protein localization|
|positive regulation of hydrolase activity|
|ion homeostasis|
|cellular component morphogenesis|
|response to lipid|
|cellular homeostasis|
|regulation of cellular localization|
|response to organic cyclic compound|
|apoptotic process|
|positive regulation of transport|
|intracellular protein transport|
|response to organonitrogen compound|
|endoplasmic reticulum|
|positive regulation of intracellular signal transduction|
|regulation of protein localization|
|programmed cell death|
|cellular response to oxygen-containing compound|
|regulation of anatomical structure morphogenesis|
|response to nitrogen compound|
|cell death|
|chemical homeostasis|
|response to abiotic stimulus|
|positive regulation of cellular component organization|
|cellular response to endogenous stimulus|
|mitochondrion|
|regulation of hydrolase activity|
|regulation of organelle organization|
|positive regulation of developmental process|
|positive regulation of catalytic activity|
|response to endogenous stimulus|
|protein transport|
|intracellular transport|
|peptide transport|
|regulation of apoptotic process|
|response to oxygen-containing compound|
|protein-containing complex assembly|
|regulation of programmed cell death|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|positive regulation of cellular protein metabolic process|
|establishment of protein localization|
|homeostatic process|
|positive regulation of signal transduction|
|regulation of cell death|
|intracellular signal transduction|
|positive regulation of protein metabolic process|
|positive regulation of molecular function|
|cellular catabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|establishment of localization in cell|
|nitrogen compound transport|
|protein-containing complex subunit organization|
|regulation of transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp8|Brefeldin A 0.02μM R00 exp8]]|-3.14|
|[[:results:exp487|Hinokiflavone 12μM R08 exp487]]|-2.47|
|[[:results:exp67|BVD-523 15μM R02 exp67]]|-2.32|
|[[:results:exp505|ML-792 0.2μM R08 exp505]]|-1.8|
|[[:results:exp46|HMS-I1 1μM R01 exp46]]|1.82|
|[[:results:exp536|Vitamin-D3 40μM R08 exp536]]|2.64|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 45/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|3/28|
|blood|5/28|
|bone|1/26|
|breast|1/33|
|central nervous system|2/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|4/13|
|fibroblast|0/1|
|gastric|1/16|
|kidney|0/21|
|liver|1/20|
|lung|3/75|
|lymphocyte|1/16|
|ovary|1/26|
|pancreas|2/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|1/24|
|soft tissue|1/9|
|thyroid|0/2|
|upper aerodigestive|5/22|
|urinary tract|3/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10180
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.76 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='FIS1 Expression in NALM6 Cells: 4.76'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>