======= FKBP4 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: FKBP4
  * **<color #00a2e8>Official Name</color>**: FKBP prolyl isomerase 4
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2288|2288]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q02790|Q02790]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=FKBP4&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20FKBP4|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600611|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Immunophilin protein with PPIase and co-chaperone activities. Component of steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). May play a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors between cytoplasm and nuclear compartments. The isomerase activity controls neuronal growth cones via regulation of TRPC1 channel opening. Acts also as a regulator of microtubule dynamics by inhibiting MAPT/TAU ability to promote microtubule assembly. May have a protective role against oxidative stress in mitochondria. {ECO:0000269|PubMed:1279700, ECO:0000269|PubMed:1376003, ECO:0000269|PubMed:19945390, ECO:0000269|PubMed:21730050, ECO:0000269|PubMed:2378870}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|TPR 2|
|FKBP C|
|TPR 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|steroid hormone receptor complex assembly|
|copper-dependent protein binding|
|FK506 binding|
|negative regulation of microtubule polymerization|
|glucocorticoid receptor binding|
|copper ion transport|
|axonal growth cone|
|phosphoprotein binding|
|androgen receptor signaling pathway|
|embryo implantation|
|negative regulation of microtubule polymerization or depolymerization|
|prostate gland development|
|tau protein binding|
|peptidyl-prolyl cis-trans isomerase activity|
|protein peptidyl-prolyl isomerization|
|regulation of microtubule polymerization|
|chaperone-mediated protein folding|
|heat shock protein binding|
|peptidyl-proline modification|
|negative regulation of protein polymerization|
|intracellular steroid hormone receptor signaling pathway|
|regulation of cellular response to heat|
|protein binding, bridging|
|regulation of microtubule polymerization or depolymerization|
|steroid hormone mediated signaling pathway|
|transition metal ion transport|
|negative regulation of protein complex assembly|
|negative regulation of supramolecular fiber organization|
|negative regulation of cytoskeleton organization|
|negative regulation of neuron projection development|
|male sex differentiation|
|intracellular receptor signaling pathway|
|hormone-mediated signaling pathway|
|female pregnancy|
|negative regulation of cell projection organization|
|cellular response to steroid hormone stimulus|
|regulation of microtubule cytoskeleton organization|
|multi-multicellular organism process|
|regulation of microtubule-based process|
|regulation of protein polymerization|
|negative regulation of neuron differentiation|
|protein folding|
|protein-containing complex localization|
|sex differentiation|
|negative regulation of neurogenesis|
|negative regulation of nervous system development|
|microtubule|
|urogenital system development|
|response to steroid hormone|
|negative regulation of cell development|
|regulation of supramolecular fiber organization|
|neuronal cell body|
|negative regulation of organelle organization|
|GTP binding|
|gland development|
|reproductive structure development|
|reproductive system development|
|regulation of protein complex assembly|
|regulation of neuron projection development|
|cellular response to lipid|
|regulation of cytoskeleton organization|
|cellular response to organic cyclic compound|
|protein-containing complex|
|cellular response to hormone stimulus|
|metal ion transport|
|regulation of neuron differentiation|
|developmental process involved in reproduction|
|regulation of plasma membrane bounded cell projection organization|
|perinuclear region of cytoplasm|
|negative regulation of cellular component organization|
|regulation of cell projection organization|
|negative regulation of cell differentiation|
|regulation of cellular response to stress|
|regulation of neurogenesis|
|cation transport|
|cellular protein-containing complex assembly|
|response to lipid|
|peptidyl-amino acid modification|
|response to hormone|
|response to organic cyclic compound|
|regulation of nervous system development|
|regulation of cell development|
|negative regulation of developmental process|
|regulation of cellular component biogenesis|
|multi-organism reproductive process|
|negative regulation of multicellular organismal process|
|cellular response to endogenous stimulus|
|mitochondrion|
|regulation of organelle organization|
|ion transport|
|RNA binding|
|reproductive process|
|reproduction|
|response to endogenous stimulus|
|regulation of response to stress|
|ATP binding|
|generation of neurons|
|protein-containing complex assembly|
|neurogenesis|
|regulation of cell differentiation|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp148|SB202190 10μM R03 exp148]]|-1.72|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|1/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12368
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -0.44 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='FKBP4 Expression in NALM6 Cells: -0.44'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>