======= FLOT1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: FLOT1
  * **<color #00a2e8>Official Name</color>**: flotillin 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10211|10211]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O75955|O75955]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=FLOT1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20FLOT1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606998|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Band 7|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of cell adhesion molecule production|
|dsRNA transport|
|regulation of cell adhesion molecule production|
|plasma membrane raft assembly|
|positive regulation of synaptic transmission, dopaminergic|
|positive regulation of toll-like receptor 3 signaling pathway|
|protein localization to membrane raft|
|flotillin complex|
|plasma membrane raft organization|
|regulation of toll-like receptor 3 signaling pathway|
|positive regulation of cell-cell adhesion mediated by cadherin|
|membrane raft assembly|
|uropod|
|dopaminergic synapse|
|protein kinase C signaling|
|positive regulation of heterotypic cell-cell adhesion|
|regulation of synaptic transmission, dopaminergic|
|cellular response to exogenous dsRNA|
|regulation of cell-cell adhesion mediated by cadherin|
|positive regulation of myoblast fusion|
|regulation of neurotransmitter uptake|
|regulation of toll-like receptor 4 signaling pathway|
|cell-cell contact zone|
|regulation of myoblast fusion|
|membrane raft organization|
|cellular response to dsRNA|
|positive regulation of toll-like receptor signaling pathway|
|positive regulation of skeletal muscle tissue development|
|regulation of heterotypic cell-cell adhesion|
|positive regulation of syncytium formation by plasma membrane fusion|
|regulation of syncytium formation by plasma membrane fusion|
|positive regulation of interferon-beta production|
|centriolar satellite|
|positive regulation of myotube differentiation|
|positive regulation of cell junction assembly|
|ionotropic glutamate receptor binding|
|membrane assembly|
|presynaptic active zone|
|COP9 signalosome|
|membrane biogenesis|
|response to exogenous dsRNA|
|regulation of interferon-beta production|
|regulation of skeletal muscle tissue development|
|cortical actin cytoskeleton|
|response to dsRNA|
|regulation of receptor internalization|
|regulation of myotube differentiation|
|positive regulation of striated muscle cell differentiation|
|extracellular matrix disassembly|
|GABA-ergic synapse|
|regulation of toll-like receptor signaling pathway|
|positive regulation of muscle organ development|
|positive regulation of striated muscle tissue development|
|positive regulation of muscle tissue development|
|caveola|
|positive regulation of type I interferon production|
|positive regulation of muscle cell differentiation|
|regulation of cell junction assembly|
|plasma membrane organization|
|positive regulation of protein binding|
|sarcolemma|
|positive regulation of endocytosis|
|regulation of receptor-mediated endocytosis|
|melanosome|
|regulation of striated muscle cell differentiation|
|protease binding|
|cell-cell adherens junction|
|regulation of type I interferon production|
|regulation of striated muscle tissue development|
|regulation of muscle tissue development|
|regulation of muscle organ development|
|regulation of Rho protein signal transduction|
|regulation of neurotransmitter transport|
|positive regulation of synaptic transmission|
|positive regulation of NF-kappaB transcription factor activity|
|regulation of muscle cell differentiation|
|microtubule organizing center|
|cell-cell junction|
|protein stabilization|
|positive regulation of binding|
|lamellipodium|
|protein localization to plasma membrane|
|nucleic acid transport|
|RNA transport|
|establishment of RNA localization|
|basolateral plasma membrane|
|regulation of endocytosis|
|RNA localization|
|regulation of protein binding|
|membrane raft|
|protein localization to cell periphery|
|nucleobase-containing compound transport|
|regulation of Ras protein signal transduction|
|cytoplasmic vesicle|
|positive regulation of cell-cell adhesion|
|early endosome|
|response to endoplasmic reticulum stress|
|positive regulation of DNA-binding transcription factor activity|
|endosome|
|regulation of protein stability|
|lysosomal membrane|
|apical plasma membrane|
|protein homooligomerization|
|extracellular matrix organization|
|positive regulation of innate immune response|
|regulation of small GTPase mediated signal transduction|
|glutamatergic synapse|
|regulation of neurotransmitter levels|
|positive regulation of response to biotic stimulus|
|axonogenesis|
|regulation of binding|
|extracellular structure organization|
|external side of plasma membrane|
|regulation of cell-cell adhesion|
|cellular component disassembly|
|positive regulation of cell adhesion|
|axon development|
|focal adhesion|
|endomembrane system organization|
|regulation of DNA-binding transcription factor activity|
|cell morphogenesis involved in neuron differentiation|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|positive regulation of cytokine production|
|regulation of innate immune response|
|positive regulation of defense response|
|neuron projection morphogenesis|
|protein localization to membrane|
|plasma membrane bounded cell projection morphogenesis|
|protein heterodimerization activity|
|cell projection morphogenesis|
|positive regulation of multi-organism process|
|cell part morphogenesis|
|protein complex oligomerization|
|positive regulation of cellular component biogenesis|
|regulation of response to biotic stimulus|
|cellular response to organic cyclic compound|
|regulation of vesicle-mediated transport|
|cell morphogenesis involved in differentiation|
|positive regulation of response to external stimulus|
|cellular response to nitrogen compound|
|neuron projection development|
|regulation of cell adhesion|
|regulation of cytokine production|
|cell morphogenesis|
|regulation of defense response|
|regulation of multi-organism process|
|neuron development|
|cellular component morphogenesis|
|membrane organization|
|positive regulation of immune response|
|response to organic cyclic compound|
|regulation of cellular component biogenesis|
|positive regulation of cell differentiation|
|positive regulation of transport|
|neuron differentiation|
|positive regulation of protein phosphorylation|
|positive regulation of phosphorylation|
|regulation of anatomical structure morphogenesis|
|response to nitrogen compound|
|regulation of response to external stimulus|
|plasma membrane bounded cell projection organization|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|positive regulation of immune system process|
|regulation of immune response|
|cell projection organization|
|positive regulation of cellular component organization|
|positive regulation of protein modification process|
|positive regulation of developmental process|
|regulation of protein phosphorylation|
|regulation of response to stress|
|generation of neurons|
|protein-containing complex assembly|
|cellular protein localization|
|regulation of phosphorylation|
|cellular macromolecule localization|
|positive regulation of cellular protein metabolic process|
|neurogenesis|
|cell development|
|regulation of immune system process|
|positive regulation of signal transduction|
|intracellular signal transduction|
|cellular response to stress|
|positive regulation of protein metabolic process|
|positive regulation of multicellular organismal process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|nitrogen compound transport|
|protein-containing complex subunit organization|
|regulation of transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 2/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|1/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3123
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.39 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='FLOT1 Expression in NALM6 Cells: 6.39'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>