======= FLOT2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: FLOT2
  * **<color #00a2e8>Official Name</color>**: flotillin 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2319|2319]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q14254|Q14254]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=FLOT2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20FLOT2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/131560|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles. May be involved in epidermal cell adhesion and epidermal structure and function.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Band 7|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of establishment of T cell polarity|
|protein localization to plasma membrane raft|
|anchored component of presynaptic active zone membrane|
|regulation of establishment of T cell polarity|
|anterograde dendritic transport|
|flotillin complex|
|protein localization to membrane raft|
|dendritic transport|
|regulation of toll-like receptor 3 signaling pathway|
|membrane raft assembly|
|uropod|
|negative regulation of amyloid precursor protein catabolic process|
|acrosomal membrane|
|membrane raft organization|
|regulation of establishment of cell polarity|
|cell-cell contact zone|
|regulation of establishment or maintenance of cell polarity|
|regulation of heterotypic cell-cell adhesion|
|dendrite cytoplasm|
|ionotropic glutamate receptor binding|
|regulation of amyloid precursor protein catabolic process|
|membrane assembly|
|membrane biogenesis|
|regulation of postsynaptic membrane neurotransmitter receptor levels|
|cortical actin cytoskeleton|
|regulation of myoblast differentiation|
|endocytic vesicle|
|axo-dendritic transport|
|regulation of toll-like receptor signaling pathway|
|caveola|
|protease binding|
|cell-cell adherens junction|
|vesicle|
|positive regulation of NF-kappaB transcription factor activity|
|transport along microtubule|
|cytoskeleton-dependent intracellular transport|
|protein stabilization|
|lamellipodium|
|microtubule-based transport|
|protein localization to plasma membrane|
|basolateral plasma membrane|
|positive regulation of T cell activation|
|positive regulation of leukocyte cell-cell adhesion|
|protein localization to cell periphery|
|cytoplasmic vesicle|
|positive regulation of cell-cell adhesion|
|positive regulation of DNA-binding transcription factor activity|
|endosome|
|microtubule-based movement|
|regulation of protein stability|
|regulation of leukocyte cell-cell adhesion|
|regulation of T cell activation|
|apical plasma membrane|
|glutamatergic synapse|
|positive regulation of lymphocyte activation|
|regulation of cell-cell adhesion|
|positive regulation of leukocyte activation|
|positive regulation of cell adhesion|
|epidermis development|
|focal adhesion|
|positive regulation of cell activation|
|regulation of DNA-binding transcription factor activity|
|regulation of innate immune response|
|protein localization to membrane|
|protein heterodimerization activity|
|regulation of lymphocyte activation|
|regulation of response to biotic stimulus|
|regulation of leukocyte activation|
|regulation of cell activation|
|microtubule-based process|
|regulation of cell adhesion|
|perinuclear region of cytoplasm|
|regulation of defense response|
|regulation of multi-organism process|
|membrane organization|
|cell adhesion|
|biological adhesion|
|regulation of response to external stimulus|
|negative regulation of protein metabolic process|
|regulation of immune response|
|positive regulation of immune system process|
|regulation of response to stress|
|intracellular transport|
|movement of cell or subcellular component|
|cellular protein localization|
|cellular macromolecule localization|
|regulation of immune system process|
|negative regulation of gene expression|
|tissue development|
|positive regulation of molecular function|
|regulation of cell differentiation|
|establishment of localization in cell|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp444|THZ531 0.225μM R08 exp444]]|-1.91|
|[[:results:exp246|UM0011500 10μM R05 exp246]]|-1.91|
|[[:results:exp33|Rotenone 2μM R00 exp33]]|-1.71|
|[[:results:exp495|IWR1 50μM R08 exp495]]|1.8|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|1.8|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|1.83|
|[[:results:exp40|2-Methoxyestradiol 0.2μM R01 exp40]]|2.11|
|[[:results:exp294|Nutlin-3A 1.6μM R06 exp294]]|2.17|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|1/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7584
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.93 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='FLOT2 Expression in NALM6 Cells: 4.93'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>