======= FLT1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: FLT1
  * **<color #00a2e8>Official Name</color>**: fms related receptor tyrosine kinase 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2321|2321]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P17948|P17948]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=FLT1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20FLT1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/165070|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the vascular endothelial growth factor receptor (VEGFR) family. VEGFR family members are receptor tyrosine kinases (RTKs) which contain an extracellular ligand-binding region with seven immunoglobulin (Ig)-like domains, a transmembrane segment, and a tyrosine kinase (TK) domain within the cytoplasmic domain. This protein binds to VEGFR-A, VEGFR-B and placental growth factor and plays an important role in angiogenesis and vasculogenesis. Expression of this receptor is found in vascular endothelial cells, placental trophoblast cells and peripheral blood monocytes. Multiple transcript variants encoding different isoforms have been found for this gene. Isoforms include a full-length transmembrane receptor isoform and shortened, soluble isoforms. The soluble isoforms are associated with the onset of pre-eclampsia.[provided by RefSeq, May 2009]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|I-set|
|V-set|
|Pkinase|
|ig|
|Pkinase Tyr|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|VEGF-B-activated receptor activity|
|VEGF-A-activated receptor activity|
|vascular endothelial growth factor receptor-1 signaling pathway|
|placental growth factor-activated receptor activity|
|negative regulation of vascular endothelial cell proliferation|
|vascular endothelial growth factor binding|
|vascular endothelial growth factor-activated receptor activity|
|positive regulation of vascular endothelial growth factor receptor signaling pathway|
|regulation of vascular endothelial cell proliferation|
|vascular endothelial growth factor signaling pathway|
|growth factor binding|
|regulation of vascular endothelial growth factor receptor signaling pathway|
|positive regulation of phosphatidylinositol 3-kinase activity|
|positive regulation of lipid kinase activity|
|negative regulation of endothelial cell proliferation|
|cellular response to vascular endothelial growth factor stimulus|
|positive regulation of phospholipase C activity|
|monocyte chemotaxis|
|regulation of phospholipase C activity|
|positive regulation of phospholipid metabolic process|
|mononuclear cell migration|
|regulation of phosphatidylinositol 3-kinase activity|
|transmembrane receptor protein tyrosine kinase activity|
|sprouting angiogenesis|
|positive regulation of phospholipase activity|
|regulation of lipid kinase activity|
|vascular endothelial growth factor receptor signaling pathway|
|regulation of phospholipase activity|
|positive regulation of lipase activity|
|regulation of phospholipid metabolic process|
|positive regulation of phosphatidylinositol 3-kinase signaling|
|regulation of lipase activity|
|regulation of phosphatidylinositol 3-kinase signaling|
|negative regulation of epithelial cell proliferation|
|myeloid leukocyte migration|
|regulation of endothelial cell proliferation|
|positive regulation of lipid metabolic process|
|peptidyl-tyrosine phosphorylation|
|leukocyte chemotaxis|
|peptidyl-tyrosine modification|
|positive regulation of angiogenesis|
|positive regulation of vasculature development|
|protein autophosphorylation|
|receptor complex|
|cell chemotaxis|
|positive regulation of ERK1 and ERK2 cascade|
|actin cytoskeleton|
|positive regulation of MAP kinase activity|
|endosome|
|regulation of cellular response to growth factor stimulus|
|regulation of angiogenesis|
|regulation of ERK1 and ERK2 cascade|
|angiogenesis|
|regulation of vasculature development|
|regulation of epithelial cell proliferation|
|positive regulation of protein serine/threonine kinase activity|
|regulation of MAP kinase activity|
|leukocyte migration|
|regulation of lipid metabolic process|
|blood vessel morphogenesis|
|focal adhesion|
|blood vessel development|
|positive regulation of cell migration|
|cellular response to growth factor stimulus|
|vasculature development|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|regulation of protein serine/threonine kinase activity|
|cardiovascular system development|
|positive regulation of cell motility|
|response to growth factor|
|positive regulation of protein kinase activity|
|positive regulation of cellular component movement|
|positive regulation of MAPK cascade|
|chemotaxis|
|positive regulation of locomotion|
|taxis|
|embryonic morphogenesis|
|positive regulation of kinase activity|
|tube morphogenesis|
|positive regulation of transferase activity|
|negative regulation of cell population proliferation|
|enzyme linked receptor protein signaling pathway|
|regulation of MAPK cascade|
|positive regulation of hydrolase activity|
|regulation of protein kinase activity|
|tube development|
|regulation of cell migration|
|circulatory system development|
|regulation of kinase activity|
|peptidyl-amino acid modification|
|anatomical structure formation involved in morphogenesis|
|regulation of cell motility|
|positive regulation of cell population proliferation|
|cell migration|
|protein phosphorylation|
|regulation of transferase activity|
|embryo development|
|regulation of locomotion|
|regulation of cellular component movement|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|positive regulation of phosphorylation|
|regulation of anatomical structure morphogenesis|
|cell motility|
|localization of cell|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|positive regulation of protein modification process|
|regulation of hydrolase activity|
|phosphorylation|
|locomotion|
|positive regulation of developmental process|
|integral component of plasma membrane|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|ATP binding|
|movement of cell or subcellular component|
|regulation of phosphorylation|
|extracellular space|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|positive regulation of signal transduction|
|positive regulation of protein metabolic process|
|positive regulation of multicellular organismal process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp159|Docetaxel 0.001 to 0.002μM on day4 R04 exp159]]|1.81|
|[[:results:exp18|Doxycycline 10μM R00 exp18]]|1.81|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.828|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17085
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.49 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='FLT1 Expression in NALM6 Cells: 4.49'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>