======= FLVCR1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: FLVCR1
  * **<color #00a2e8>Official Name</color>**: FLVCR heme transporter 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=28982|28982]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y5Y0|Q9Y5Y0]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=FLVCR1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20FLVCR1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/609144|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the major facilitator superfamily of transporter proteins. The encoded protein is a heme transporter that may play a critical role in erythropoiesis by protecting developing erythroid cells from heme toxicity. This gene may play a role in posterior column ataxia with retinitis pigmentosa and the hematological disorder Diamond-Blackfan syndrome. [provided by RefSeq, Jan 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Isoform 1: Heme transporter that exports cytoplasmic heme. It can also export coproporphyrin and protoporphyrin IX, which are both intermediate products in the heme biosynthetic pathway. Does not export bilirubin. Heme export depends on the presence of HPX and is required to maintain intracellular free heme balance, protecting cells from heme toxicity. Heme export provides protection from heme or ferrous iron toxicities in liver, brain, sensory neurons and during erythtopoiesis, a process in which heme synthesis intensifies. Causes susceptibility to FeLV-C in vitro. {ECO:0000269|PubMed:10400745, ECO:0000269|PubMed:15369674, ECO:0000269|PubMed:20610401, ECO:0000269|PubMed:27923065}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|MFS 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|heme export|
|heme transporter activity|
|heme transport|
|iron coordination entity transport|
|erythrocyte maturation|
|erythrocyte development|
|spleen development|
|head morphogenesis|
|transporter activity|
|body morphogenesis|
|cofactor transport|
|myeloid cell development|
|embryonic digit morphogenesis|
|cellular iron ion homeostasis|
|iron ion transport|
|iron ion homeostasis|
|erythrocyte differentiation|
|multicellular organism growth|
|erythrocyte homeostasis|
|regulation of organ growth|
|embryonic skeletal system morphogenesis|
|mitochondrial membrane|
|cellular transition metal ion homeostasis|
|myeloid cell homeostasis|
|transition metal ion transport|
|embryonic appendage morphogenesis|
|embryonic limb morphogenesis|
|embryonic skeletal system development|
|transition metal ion homeostasis|
|anatomical structure maturation|
|heme binding|
|appendage morphogenesis|
|limb morphogenesis|
|cell maturation|
|limb development|
|appendage development|
|homeostasis of number of cells|
|mitochondrial transport|
|myeloid cell differentiation|
|skeletal system morphogenesis|
|developmental maturation|
|embryonic organ morphogenesis|
|regulation of developmental growth|
|in utero embryonic development|
|developmental growth|
|growth|
|embryonic organ development|
|blood vessel development|
|skeletal system development|
|vasculature development|
|cardiovascular system development|
|hemopoiesis|
|cellular metal ion homeostasis|
|embryonic morphogenesis|
|hematopoietic or lymphoid organ development|
|metal ion homeostasis|
|chordate embryonic development|
|cellular cation homeostasis|
|metal ion transport|
|cellular ion homeostasis|
|immune system development|
|embryo development ending in birth or egg hatching|
|regulation of growth|
|cation homeostasis|
|inorganic ion homeostasis|
|cellular chemical homeostasis|
|head development|
|ion homeostasis|
|cation transport|
|circulatory system development|
|cellular homeostasis|
|animal organ morphogenesis|
|embryo development|
|chemical homeostasis|
|mitochondrion|
|transmembrane transport|
|ion transport|
|integral component of plasma membrane|
|homeostatic process|
|cell development|
|nitrogen compound transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp164|Q15 1 to 2μM on day4 R04 exp164]]|-4.68|
|[[:results:exp445|∆-9-Tetrahydrocannabinol 30μM R08 exp445]]|-4.63|
|[[:results:exp510|Nicotine 3000μM R08 exp510]]|-4.61|
|[[:results:exp152|SGC2043 10μM R03 exp152]]|-4.6|
|[[:results:exp47|Lapatinib 5μM R01 exp47]]|-4.44|
|[[:results:exp359|FK-506 30μM R07 exp359]]|-4.02|
|[[:results:exp483|FTY720 3μM R08 exp483]]|-4.01|
|[[:results:exp461|BS-181 20μM R08 exp461]]|-3.86|
|[[:results:exp470|Chloroquine 32μM R08 exp470]]|-3.84|
|[[:results:exp453|B02 10μM R08 exp453]]|-3.78|
|[[:results:exp233|EPZ-5676 30μM R05 exp233]]|-3.78|
|[[:results:exp504|MK2206 4μM R08 exp504]]|-3.74|
|[[:results:exp465|Cannabidiol 13μM R08 exp465]]|-3.72|
|[[:results:exp442|Ibrutinib 10μM R08 exp442]]|-3.7|
|[[:results:exp182|IU1-47 25μM R04 exp182]]|-3.68|
|[[:results:exp67|BVD-523 15μM R02 exp67]]|-3.58|
|[[:results:exp358|FK-506 5μM R07 exp358]]|-3.58|
|[[:results:exp422|Wiskostatin 3μM R07 exp422]]|-3.49|
|[[:results:exp341|BRD2 inhibitor II 20μM R07 exp341]]|-3.31|
|[[:results:exp149|SB203580 25μM R03 exp149]]|-3.3|
|[[:results:exp530|Thioridazine 5μM R08 exp530]]|-3.3|
|[[:results:exp538|ZLN024 50μM R08 exp538]]|-3.24|
|[[:results:exp490|Hydroxychloroquine 30μM R08 exp490]]|-3.2|
|[[:results:exp68|Clomiphene 4.4μM R02 exp68]]|-3.12|
|[[:results:exp224|CB-839 10μM R05 exp224]]|-3.03|
|[[:results:exp344|Chlorpromazine 10μM R07 exp344]]|-3|
|[[:results:exp183|IU1-C 25μM R04 exp183]]|-2.99|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|-2.85|
|[[:results:exp114|A-196 10μM R03 exp114]]|-2.84|
|[[:results:exp508|NN-Dimethylsphingosine 2.5μM R08 exp508]]|-2.8|
|[[:results:exp452|Azithromycin 100μM R08 exp452]]|-2.78|
|[[:results:exp469|CFI-400945 25μM R08 exp469]]|-2.78|
|[[:results:exp89|Vemurafenib 6.6μM R02 exp89]]|-2.68|
|[[:results:exp466|Cannabidiol 20μM R08 exp466]]|-2.65|
|[[:results:exp90|WYE-354 6μM R02 exp90]]|-2.61|
|[[:results:exp26|Oligomycin-A 20μM R00 exp26]]|-2.6|
|[[:results:exp83|Trametinib 10μM R02 exp83]]|-2.53|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|-2.52|
|[[:results:exp79|Q15 2.7μM R02 exp79]]|-2.51|
|[[:results:exp131|L-74142 5μM R03 exp131]]|-2.43|
|[[:results:exp326|CCT251545 20μM R07 exp326]]|-2.39|
|[[:results:exp308|Rapamycin 2μM plus FK-506 5μM R07 exp308]]|-2.37|
|[[:results:exp433|LJH685 50μM R08 exp433]]|-2.27|
|[[:results:exp307|Rapamycin 2μM plus Cyclosporin-A 3μM R07 exp307]]|-2.18|
|[[:results:exp467|CAY10603 0.55μM R08 exp467]]|-2.12|
|[[:results:exp348|Cyclosporin-A 3μM R07 exp348]]|-2.08|
|[[:results:exp124|GSK343 3μM R03 exp124]]|-2.06|
|[[:results:exp151|SGC0946 7μM R03 exp151]]|-2.06|
|[[:results:exp234|Ethanol 0.01 R05 exp234]]|-2.05|
|[[:results:exp155|UNC1999 2μM R03 exp155]]|-2|
|[[:results:exp50|Nicotinamide 2000μM R01 exp50]]|-1.85|
|[[:results:exp77|Prochlorperazine 5.2μM R02 exp77]]|-1.83|
|[[:results:exp150|SGC0649 7μM R03 exp150]]|-1.8|
|[[:results:exp436|Dynasore 7μM R08 exp436]]|-1.78|
|[[:results:exp156|UNC2400 2μM R03 exp156]]|-1.72|
|[[:results:exp430|Rifampicin 30μM R08 exp430]]|-1.71|
|[[:results:exp457|Bisphenol F 50μM R08 exp457]]|-1.7|
|[[:results:exp71|KU-0063794 3.8μM R02 exp71]]|-1.7|
|[[:results:exp487|Hinokiflavone 12μM R08 exp487]]|1.75|
|[[:results:exp513|ONC212 0.15μM R08 exp513]]|1.83|
|[[:results:exp439|QNZ 0.01μM R08 exp439]]|2|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:c:chka|CHKA]]|0.74|
|[[:human genes:c:cept1|CEPT1]]|0.634|
|[[:human genes:s:slc5a3|SLC5A3]]|0.535|
|[[:human genes:p:pcyt1a|PCYT1A]]|0.524|
|[[:human genes:m:mbtps1|MBTPS1]]|0.524|
|[[:human genes:k:kdsr|KDSR]]|0.493|
|[[:human genes:v:vkorc1l1|VKORC1L1]]|0.476|
|[[:human genes:a:arpc2|ARPC2]]|0.466|
|[[:human genes:s:sptlc2|SPTLC2]]|0.46|
|[[:human genes:g:gpr107|GPR107]]|0.457|
|[[:human genes:a:atp2a2|ATP2A2]]|0.455|
|[[:human genes:d:dolk|DOLK]]|0.445|
|[[:human genes:a:alg5|ALG5]]|0.439|
|[[:human genes:p:ptdss1|PTDSS1]]|0.429|
|[[:human genes:a:arpc4|ARPC4]]|0.427|
|[[:human genes:g:gpr89a|GPR89A]]|0.425|
|[[:human genes:c:cnep1r1|CNEP1R1]]|0.424|
|[[:human genes:p:ppa2|PPA2]]|0.415|
|[[:human genes:s:sptlc1|SPTLC1]]|0.414|
|[[:human genes:c:ctdnep1|CTDNEP1]]|0.412|
|[[:human genes:u:uso1|USO1]]|0.403|
|[[:human genes:a:arl1|ARL1]]|0.402|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 3/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|1/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|1/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|1/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4071
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.89 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='FLVCR1 Expression in NALM6 Cells: 5.89'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>