======= FNIP1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: FNIP1
  * **<color #00a2e8>Official Name</color>**: folliculin interacting protein 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=96459|96459]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8TF40|Q8TF40]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=FNIP1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20FNIP1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/610594|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Acts as a co-chaperone of HSP90AA1. Inhibits the ATPase activity of HSP90AA1 leading to reduction in its chaperone activity. Facilitates the binding of client protein FLCN to HSP90AA1. Competes with the activating co-chaperone AHSA1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins (PubMed:27353360). May be involved in energy and/or nutrient sensing through the AMPK and mTOR signaling pathways (PubMed:17028174). May regulate phosphorylation of RPS6KB1 (PubMed:18663353). {ECO:0000269|PubMed:17028174, ECO:0000269|PubMed:18663353, ECO:0000269|PubMed:27353360}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of B cell apoptotic process|
|ATPase inhibitor activity|
|regulation of pro-B cell differentiation|
|regulation of lymphoid progenitor cell differentiation|
|immature B cell differentiation|
|regulation of B cell apoptotic process|
|positive regulation of lymphocyte apoptotic process|
|negative regulation of TORC1 signaling|
|positive regulation of leukocyte apoptotic process|
|TOR signaling|
|regulation of TORC1 signaling|
|negative regulation of TOR signaling|
|regulation of lymphocyte apoptotic process|
|negative regulation of mitochondrion organization|
|regulation of leukocyte apoptotic process|
|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|regulation of hematopoietic progenitor cell differentiation|
|negative regulation of cysteine-type endopeptidase activity|
|regulation of TOR signaling|
|chaperone binding|
|guanyl-nucleotide exchange factor activity|
|positive regulation of peptidyl-serine phosphorylation|
|B cell differentiation|
|regulation of peptidyl-serine phosphorylation|
|cellular response to starvation|
|B cell activation|
|regulation of mitochondrion organization|
|response to starvation|
|regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|cellular response to nutrient levels|
|lymphocyte differentiation|
|regulation of cysteine-type endopeptidase activity|
|negative regulation of endopeptidase activity|
|positive regulation of protein complex assembly|
|negative regulation of peptidase activity|
|cellular response to extracellular stimulus|
|leukocyte differentiation|
|cellular response to external stimulus|
|negative regulation of proteolysis|
|negative regulation of organelle organization|
|lymphocyte activation|
|regulation of endopeptidase activity|
|regulation of peptidase activity|
|regulation of protein complex assembly|
|regulation of hemopoiesis|
|negative regulation of hydrolase activity|
|response to nutrient levels|
|negative regulation of intracellular signal transduction|
|positive regulation of cellular component biogenesis|
|response to extracellular stimulus|
|hemopoiesis|
|hematopoietic or lymphoid organ development|
|positive regulation of apoptotic process|
|immune system development|
|positive regulation of programmed cell death|
|positive regulation of cell death|
|negative regulation of cellular component organization|
|regulation of proteolysis|
|negative regulation of catalytic activity|
|negative regulation of transcription by RNA polymerase II|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|leukocyte activation|
|regulation of cellular component biogenesis|
|negative regulation of cell death|
|positive regulation of protein phosphorylation|
|negative regulation of cellular protein metabolic process|
|positive regulation of phosphorylation|
|cell activation|
|negative regulation of protein metabolic process|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|negative regulation of molecular function|
|negative regulation of transcription, DNA-templated|
|positive regulation of cellular component organization|
|positive regulation of protein modification process|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of signal transduction|
|regulation of hydrolase activity|
|regulation of organelle organization|
|negative regulation of RNA metabolic process|
|negative regulation of cell communication|
|negative regulation of signaling|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|regulation of protein phosphorylation|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|regulation of apoptotic process|
|negative regulation of biosynthetic process|
|regulation of programmed cell death|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|negative regulation of response to stimulus|
|regulation of immune system process|
|regulation of cell death|
|intracellular signal transduction|
|cellular response to stress|
|positive regulation of protein metabolic process|
|negative regulation of gene expression|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp38|Wortmannin 5μM R00 exp38]]|-2.23|
|[[:results:exp71|KU-0063794 3.8μM R02 exp71]]|-1.93|
|[[:results:exp345|Cidofovir 10μM R07 exp345]]|-1.8|
|[[:results:exp300|VE-822 0.04μM R06 exp300]]|-1.73|
|[[:results:exp136|MS094 2μM R03 exp136]]|-1.71|
|[[:results:exp175|3-Bromopyruvate 7μM R04 exp175]]|1.88|
|[[:results:exp474|CR131-b 0.005μM R08 exp474]]|1.98|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|4.72|
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|4.87|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:f:flcn|FLCN]]|0.693|
|[[:human genes:l:lamtor4|LAMTOR4]]|0.665|
|[[:human genes:l:lamtor2|LAMTOR2]]|0.659|
|[[:human genes:r:rraga|RRAGA]]|0.595|
|[[:human genes:w:wdr24|WDR24]]|0.591|
|[[:human genes:m:mios|MIOS]]|0.564|
|[[:human genes:c:ccnc|CCNC]]|0.527|
|[[:human genes:c:casp3|CASP3]]|0.519|
|[[:human genes:t:tbc1d5|TBC1D5]]|0.507|
|[[:human genes:l:lamtor1|LAMTOR1]]|0.494|
|[[:human genes:l:lamtor5|LAMTOR5]]|0.494|
|[[:human genes:l:lamtor3|LAMTOR3]]|0.479|
|[[:human genes:g:gabarap|GABARAP]]|0.468|
|[[:human genes:v:vps41|VPS41]]|0.454|
|[[:human genes:l:lsm12|LSM12]]|0.448|
|[[:human genes:f:fbxo11|FBXO11]]|0.434|
|[[:human genes:t:tnfrsf10b|TNFRSF10B]]|0.434|
|[[:human genes:c:clk3|CLK3]]|0.433|
|[[:human genes:e:eif4g1|EIF4G1]]|0.424|
|[[:human genes:p:pax5|PAX5]]|0.424|
|[[:human genes:f:fadd|FADD]]|0.421|
|[[:human genes:s:spop|SPOP]]|0.42|
|[[:human genes:t:thoc6|THOC6]]|0.414|
|[[:human genes:w:wdr59|WDR59]]|0.413|
|[[:human genes:m:med13l|MED13L]]|0.406|
|[[:human genes:k:khdrbs1|KHDRBS1]]|0.406|
|[[:human genes:z:znf217|ZNF217]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|1/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2859
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.15 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='FNIP1 Expression in NALM6 Cells: 5.15'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>