======= FOLR1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: FOLR1
  * **<color #00a2e8>Official Name</color>**: folate receptor alpha
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2348|2348]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P15328|P15328]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=FOLR1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20FOLR1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/136430|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a member of the folate receptor family. Members of this gene family bind folic acid and its reduced derivatives, and transport 5-methyltetrahydrofolate into cells. This gene product is a secreted protein that either anchors to membranes via a glycosyl-phosphatidylinositol linkage or exists in a soluble form. Mutations in this gene have been associated with neurodegeneration due to cerebral folate transport deficiency. Due to the presence of two promoters, multiple transcription start sites, and alternative splicing, multiple transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Oct 2009]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release. Required for normal embryonic development and normal cell proliferation. {ECO:0000269|PubMed:23851396, ECO:0000269|PubMed:23934049, ECO:0000269|PubMed:2527252, ECO:0000269|PubMed:8033114, ECO:0000269|PubMed:8567728}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Folate rec|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|neural crest cell migration involved in heart formation|
|cellular response to folic acid|
|cell migration involved in heart formation|
|folic acid receptor activity|
|methotrexate binding|
|anterior neural tube closure|
|cardiac neural crest cell migration involved in outflow tract morphogenesis|
|folate import across plasma membrane|
|cardiac neural crest cell development involved in outflow tract morphogenesis|
|folate transmembrane transport|
|cardiac neural crest cell differentiation involved in heart development|
|cardiac neural crest cell development involved in heart development|
|pharyngeal arch artery morphogenesis|
|folic acid transport|
|response to folic acid|
|folic acid binding|
|heart formation|
|cell migration involved in heart development|
|vitamin transmembrane transport|
|anchored component of external side of plasma membrane|
|folic acid metabolic process|
|axon regeneration|
|cellular response to vitamin|
|modified amino acid transport|
|pharyngeal system development|
|folic acid-containing compound metabolic process|
|neuron projection regeneration|
|animal organ formation|
|pteridine-containing compound metabolic process|
|vitamin transport|
|cofactor transport|
|response to axon injury|
|brush border membrane|
|ER to Golgi transport vesicle membrane|
|neural crest cell migration|
|drug binding|
|clathrin-coated vesicle|
|heart looping|
|artery morphogenesis|
|vesicle targeting, rough ER to cis-Golgi|
|COPII vesicle coating|
|embryonic heart tube morphogenesis|
|determination of heart left/right asymmetry|
|cellular response to nutrient|
|vesicle coating|
|COPII-coated vesicle budding|
|vesicle targeting, to, from or within Golgi|
|endoplasmic reticulum-Golgi intermediate compartment membrane|
|drug transmembrane transport|
|outflow tract morphogenesis|
|embryonic heart tube development|
|Golgi vesicle budding|
|neural crest cell development|
|dicarboxylic acid transport|
|stem cell development|
|mesenchymal cell development|
|artery development|
|response to vitamin|
|water-soluble vitamin metabolic process|
|neural crest cell differentiation|
|vesicle targeting|
|neural tube closure|
|transport vesicle|
|tube closure|
|dicarboxylic acid metabolic process|
|import across plasma membrane|
|vesicle budding from membrane|
|primary neural tube formation|
|neural tube formation|
|regulation of transforming growth factor beta receptor signaling pathway|
|regulation of cellular response to transforming growth factor beta stimulus|
|cardiocyte differentiation|
|determination of left/right symmetry|
|embryonic epithelial tube formation|
|determination of bilateral symmetry|
|vitamin metabolic process|
|specification of symmetry|
|organic acid transmembrane transport|
|carboxylic acid transmembrane transport|
|epithelial tube formation|
|morphogenesis of embryonic epithelium|
|tube formation|
|drug transport|
|mesenchymal cell differentiation|
|regeneration|
|stem cell differentiation|
|neural tube development|
|ameboidal-type cell migration|
|establishment of vesicle localization|
|vesicle localization|
|basolateral plasma membrane|
|cellular modified amino acid metabolic process|
|signaling receptor activity|
|cellular response to acid chemical|
|endoplasmic reticulum to Golgi vesicle-mediated transport|
|response to nutrient|
|mesenchyme development|
|cellular response to nutrient levels|
|regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|receptor-mediated endocytosis|
|coenzyme metabolic process|
|heart morphogenesis|
|cellular response to extracellular stimulus|
|endosome|
|regulation of cellular response to growth factor stimulus|
|anion transmembrane transport|
|regulation of canonical Wnt signaling pathway|
|embryonic organ morphogenesis|
|carboxylic acid transport|
|organic acid transport|
|vesicle organization|
|epithelial tube morphogenesis|
|apical plasma membrane|
|cellular response to external stimulus|
|response to acid chemical|
|regulation of Wnt signaling pathway|
|establishment of organelle localization|
|Golgi vesicle transport|
|cellular response to drug|
|blood vessel morphogenesis|
|axon development|
|morphogenesis of an epithelium|
|embryonic organ development|
|pattern specification process|
|cofactor metabolic process|
|organic anion transport|
|blood vessel development|
|response to nutrient levels|
|drug metabolic process|
|vasculature development|
|cardiovascular system development|
|heart development|
|response to extracellular stimulus|
|cellular response to organic cyclic compound|
|endocytosis|
|tissue morphogenesis|
|embryonic morphogenesis|
|response to wounding|
|organelle localization|
|anion transport|
|cellular response to organonitrogen compound|
|cell surface|
|Golgi membrane|
|chordate embryonic development|
|embryo development ending in birth or egg hatching|
|tube morphogenesis|
|cellular response to nitrogen compound|
|neuron projection development|
|import into cell|
|cellular amide metabolic process|
|neuron development|
|tube development|
|membrane organization|
|circulatory system development|
|anatomical structure formation involved in morphogenesis|
|carboxylic acid metabolic process|
|response to organic cyclic compound|
|endoplasmic reticulum membrane|
|ion transmembrane transport|
|animal organ morphogenesis|
|cell migration|
|embryo development|
|response to organonitrogen compound|
|oxoacid metabolic process|
|neuron differentiation|
|response to drug|
|organic acid metabolic process|
|cellular response to oxygen-containing compound|
|localization of cell|
|cell motility|
|response to nitrogen compound|
|epithelium development|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|cellular response to endogenous stimulus|
|transmembrane transport|
|locomotion|
|ion transport|
|response to endogenous stimulus|
|intracellular transport|
|generation of neurons|
|movement of cell or subcellular component|
|response to oxygen-containing compound|
|protein-containing complex assembly|
|amide transport|
|neurogenesis|
|cell development|
|cellular response to stress|
|small molecule metabolic process|
|tissue development|
|establishment of localization in cell|
|nitrogen compound transport|
|protein-containing complex subunit organization|
|vesicle-mediated transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp14|Cycloheximide 0.02μM R00 exp14]]|-1.81|
|[[:results:exp514|Phorbol-12-myristate-13-acetate 0.57μM R08 exp514]]|1.93|
|[[:results:exp123|GSK-LSD1 10μM R03 exp123]]|2.32|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10821
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -7.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='FOLR1 Expression in NALM6 Cells: -7.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>